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Pericytes and Adaptive Angioplasticity: The Role of Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK)

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Cerebral Angiogenesis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1135))

Abstract

The TNF superfamily member TWEAK has emerged as a pleiotropic cytokine that regulates many cellular functions that include immune/inflammatory activity, angiogenesis, cell proliferation, and fate. TWEAK through its inducible receptor, FGF-inducible molecule 14 (Fn14), can induce both beneficial and deleterious activity that has a profound effect on cell survival. Thus it is highly likely that TWEAK and Fn14 expressed by cells of the neurovascular unit help regulate and maintain vascular and tissue homeostasis. In this chapter we discuss the expression of TWEAK and Fn14 signaling in the cerebral microvascular pericyte. Pericytes are a highly enigmatic population of microvascular cells that are important in regulatory pathways that modulate physiological angiogenesis in response to chronic mild hypoxic stress. A brief introduction will identify the microvascular pericyte. A more detailed discussion of pericyte TWEAK signaling during adaptive angioplasticity will follow.

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Authors and Affiliations

  1. Division of Neuroimmunology, Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA

    Paula Dore-Duffy

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  1. Paula Dore-Duffy
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Editors and Affiliations

  1. Scripps Research Institute, La Jolla, California, USA

    Richard Milner

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Dore-Duffy, P. (2014). Pericytes and Adaptive Angioplasticity: The Role of Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK). In: Milner, R. (eds) Cerebral Angiogenesis. Methods in Molecular Biology, vol 1135. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0320-7_4

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  • DOI: https://doi.org/10.1007/978-1-4939-0320-7_4

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0319-1

  • Online ISBN: 978-1-4939-0320-7

  • eBook Packages: Springer Protocols

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