Abstract
ATP production in the fetal rat liver is mainly glycolytic, glucose being supplied by the mother’s blood (1). The capacity of liver mitochondria for ATP synthesis coupled to succinate oxidation is low at birth. It increases by 70% between delivery and two hours after birth as shown by the respiratory control ratios obtained, reflecting a rapid mitochondrial maturation (2). This improvement in the capacity of ATP synthesis through the oxidative phosphorylation machinery is one of the early events occurring in rat liver mitochondria at birth. The rapid mechanism by which this improvement occurs is not yet fully understood.
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References
F.C. Battaglia and G. Meschia, 1978, Principal substrates of fetal metabolism. Physiol. Rev., 58, 499–527.
R. Meister, J. Comte, L. Baggetto, C. Godinot and D.C. Gautheron, 1983, Inhibitory effects of glucose on the maturation of rat liver mitochondria at birth. Phospholipid and oxidative metabolism, Biochim. Biophys. Acta, 722, 36–42.
J.R. Girard, G.S. Cuendet, E.B. Marliss, A. Kervran, M. Rieutort and R. Assan, 1973, Fuels, hormones and liver metabolism at term and during the early postnatal period in the rat, J. Clin. Invest., 52, 3190–3200.
P.N. Di Marco and T. Oliver, 1978, Adenosine 3&2032;,5′-Monophosphate in perinatal rat liver; ontogeny and response to hormones. Eur. J. Biochem. 87, 235–241.
J. Comte, R. Meister, L.G. Baggetto, C. Godinot and D.C. Gautheron, 1986, Reversal of glucose-induced inhibition of newborn rat liver mitochondrial maturation by administration of alkylxanthines at birth, Biochem. Pharmacol., 35, 2411–2416.
J.R. Aprille and G.K. Asimakis, 1980, Postnatal development of rat liver mitochondria: state 3 respiration, adenine nucleotide translocase activity and net accumulation of adenine nucleotides, Arch. Biochem. Biophys., 201, 564–575.
L.J. Ignarro and P.J. Kadowitz, 1985, The pharmacological and physiologial role of cyclic GMP in vascular smooth muscle relaxation, Ann. Rev. Pharmacol. Toxicol., 25, 171–191.
K. Cheng and J. Lamer, 1985, Intracellular mediators of insulin action, Ann. Rev. Physiol., 47, 405–424.
G. Illiano, G.P.E. Tell, M.I. Siegel and P. Cuatrecasas, 1973, Guanosine 3′,5′-cyclic monophosphate and the action of insulin and acetylcholine, Proc. Natl. Acad. Sci USA, 70, 2443–2447.
J.K. Pollak, 1975, The maturation of the inner membrane of foetal rat liver mitochondria, Biochem. J., 150, 477–488.
J. Austin and J.R. Aprille, 1984, Carboxyatractyloside-insensitive influx and efflux of adenine nucleotides in rat liver mitochondria, J. Biol. Chem., 259, 154–160.
J.R. Aprille, 1987, Physiological sigificance of new adenine nucleo tide transport mechanism in liver mitochondrial, this book.
K. Sandor and J.K. Pollak, 1976, The mechanism of mitochondrial maturation in the liver of the perinatal rat, Biochem. Soc. Trans. 4, 1122–1124.
J.K. Pollak and W. Harsas, 1981, Changes in the phospholipid catabolism of mitochondria and microsomes during the development of rat liver, Biochem. J., 200, 521–528.
M. Hallman, 1971, Changes in mitochondrial respiration chain proteins during perinatal development. Evidence of the importance of environmental oxygen tension, Biochim. Biophys. Acta, 253, 360–372.
L. Baggetto, J. Comte, R. Meister and C. Godinot, 1983, High phosphate requirement for oxidative phosphorylation and low affinity fo phosphate transport in newborn rat liver mitochondria, Biochimie, 6 685–690.
L. Baggetto, D.C. Gautheron and C. Godinot, 1984, Effects of ATP on various steps controlling the rate of oxidative phosphorylation in newborn rat liver mitochondria, Arch. Biochem. Biophys., 232, 67 678.
V. Stefanovitch, 1978, The biochemical mechanism of action of pentoxifylline, Pharmatherapeutica, 2, Supplem. 1, 5–16.
U. Walter, 1984, in Cyclic-cGMP regulated enzymes and their possible physiological functions, Adv. Cyclic Nucleotide Res., 17, 249–274.
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© 1988 Springer Science+Business Media New York
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Gautheron, D.C., Comte, J., Meister, R. (1988). Cyclic Nucleotides and Mitochondrial Functions at Birth. In: Lemasters, J.J., Hackenbrock, C.R., Thurman, R.G., Westerhoff, H.V. (eds) Integration of Mitochondrial Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2551-0_43
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DOI: https://doi.org/10.1007/978-1-4899-2551-0_43
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