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Cytokines and Sleep Mechanisms

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Advances in Psychoneuroimmunology

Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HSSN,volume 3))

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Abstract

The primary thesis of this essay is that infectious disease induces changes in sleep and that these sleep alterations are mediated by cytokines. More specifically, we propose that specific microbial products stimulate cytokine production and that these cytokines, in turn, induce the changes in sleep that occur during infections. Included in this scheme is the proposal that the cytokine interleukin-1 (IL1) is also involved in physiological sleep regulation.

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Authors and Affiliations

  1. Departments of Physiology & Biophysics, University of Tennessee, Memphis, 894 Union Avenue, Memphis, TN, 38163, USA

    James M. Krueger

  2. Departments of Comparative Medicine, University of Tennessee, 894 Union Avenue, Memphis, TN, 38163, USA

    Linda Toth

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  1. James M. Krueger
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Editors and Affiliations

  1. Department of Immunology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Istvan Berczi

  2. National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary

    Judith Szélenyi

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Krueger, J.M., Toth, L. (1994). Cytokines and Sleep Mechanisms. In: Berczi, I., Szélenyi, J. (eds) Advances in Psychoneuroimmunology. Hans Selye Symposia on Neuroendocrinology and Stress, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9104-4_12

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  • DOI: https://doi.org/10.1007/978-1-4757-9104-4_12

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