Abstract
Atopic allergy is a genetically determined disorder characterized by an increased ability of B-lymphocytes to form immunoglobulin E (IgE) antibodies to certain groups of ubiquitous antigens that can activate the immune system after inhalation or ingestion, and perhaps after penetration through the skin (allergens). IgE antibodies are able to bind to high-affinity (type I) Fce receptors (FcεRI) present on the surface of mast cells/basophils, and allergen-induced FcεRI cross linking triggers the release of vasoactive mediators, chemotactic factors, and cytokines that are responsible for the allergic cascade. In addition to IgE-producing B-cells and IgE-binding mast cells/basophils, eosinophils also appear to be involved in the pathogenesis of allergic reactions, since these cells usually accumulate in the sites of allergic inflammation and the toxic products they release significantly contribute to the induction of tissue damage. The mechanisms accounting for the joint involvement of IgE-producing B-cells, mast cells/basophils, and eosinophils in the pathogenesis of allergic reactions had remained unclear until the existence of two polarized forms of the cluster differentiation (CD)4+ T-helper (Th) cell-mediated specific immune response, based on their profile of cytokine production and defined as type 1 T-helper (Thl) and type 2 T-helper (Th2), was discovered (1).
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References
Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 7: 145–173.
Romagnani S (1994) Lymphokine production by human T cells in disease states. Ann Rev Immunol 12: 227–257.
Romagnani S (1994) Thl versus Th2 responses in AIDS. Curr Opin Immunol 6: 616–622.
Seder RA, Paul WE (1994) Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 12: 635–674.
Kelso A (1995) Thl and Th2 subsets: paradigm lost? Immunol Today 16: 374–379.
Romagnani S (1991) Human TH1 and TH2: doubt no more. Immunol Today 12: 256–257.
Kapsenberg ML, Wierenga EA, Bos JD, Jansen HM (1991) Functional subsets of allergen-reactive human CD4’ T cells. Immunol Today 12: 392–395.
Del Prete GF, De Carli M, Mastromauro C, Macchia D, Biagiotti R, Ricci M, Romagnani S (1991) Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 88: 346–351.
Smith CA, Gruss H-J, Davis T, Anderson D, Farrah T, Baker E, Sutherland GR, Brannan CI, Copeland NG, Jenkins NA, Grabstein KH, Gliniak B, McAllister IB, Fanslow W, Alderson M, Falk B, Gimpel S, Gillis S, Din WS, Goodwin R, Armitage RJ (1993) CD30 antigen, a marker for Hodgkin’s lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell 73: 1349–1360.
Del Prete, G-F, De Carli M, Almerigogna F, Daniel KC, D’Elios MM, Zancuoghi D, Vinante E, Pizzolo G, Romagnani S (1995) Preferential expression of CD30 by human CD4+ T cells producing Th2-type cytokines. FASEB J 9: 81–86.
Del Prete G-F, De Carli M, D’Elios MM, Daniel KC, Smith CA, Thomas E, Romagnani S (1995) CD30mediated signalling promotes the development of human Th2-like T cells. J Exp Med 182: 1–7.
McDonald PP, Cassatella MA, Bald A, Maggi E, Romagnani S, Gruss H-J, Pizzolo G (1995) CD30 ligation induces nuclear factor-KB activation in human T cell lines. Eur J Immunol 25: 2870–2876.
Schanden L, Ferster A, Mascart-Lemone F, Crusiaux A, Gerard C, Marchant A, Lybin M, Velu T, Sariban E, Goldman M (1993) T helper type 2-like cells and therapeutic effects of interferon-y in combined immunodeficiency with hypereosinophilia ( Omenn’s syndrome ). Eur J Immunol 23: 56–60.
Chilosi M, Facchetti F, Notarangelo LD, Romagnani S, Del Prete G-F, Almerigogna F, De Carli M, Pizzolo G (1995) CD30 cell expression and abnormal soluble CD30 serum accumulation in Omenn’s syndrome. Evidence for a Th2-mediated condition. Eur J Immunol 26: 329–334.
Triebel F, Jitsukawa S, Baixeras E, Roman-Roman S, Genevee C, Viegas-Pequignot E, Hercend T (1990) LAG-3, a novel lymphocyte activation gene closely related to CD4. J Exp Med 171: 1393–1405.
Annunziato F, Manetti R, Tomasevic L, Giudizi M-G, Biagiotti R, Giannò V, Germano P, Mavilia C, Maggi E, Romagnani S (1996) Expression and release of LAG-3-encoded protein by human CD4+ T-cells are associated with IFN-production. FASEB J 10: 769–776.
Romagnani S (1994) Regulation of the development of type 2 T-helper cells in allergy. Curr Opin Immunol 6: 838–846.
Romagnani S (1995) Atopic allergy and other hypersensitivities. Editorial overview: Technological advances and new insights into pathogenesis prelude novel therapeutic strategies. Curr Opin Immunol 7: 745–750.
Wierenga EA, Snoek M, de Groot C, Chretien I, Bos JD, Jansen HM, Kapsenberg ML (1990) Evidence for compartmentalization of functional subsets of CD4+ T-lymphocytes in atopic patients. J Immunol 144: 4651–4656.
Parronchi P, Macchia D, Piccinni M-P, Biswas P, Simonelli C, Maggi E, Ricci M, Ansari AA, Romagnani S (1991) Allergen-and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci USA 88: 4538–4542.
Maggi E, Biswas P, Del Prete GF, Parronchi P, Macchia D, Simonelli C, Emmi L, De Carli M, Tiri A, Ricci M, Romagnani S (1991) Accumulation of Th2-like helper T-cells in the conjunctiva of patients with vernal conjunctivitis. J Inununol 146: 1169–1174.
van der Heijden FL, Wierenga EA, Bos JD, Kapsenberg ML (1991) High frequency of IL-4-producing CD4+ allergen-specific T lymphocytes in atopic dermatitis lesional skin. J Invest Dermatol 97: 389–394.
Hamid Q, Azzawi M, Ying S, Moqbel R, Wardlaw AJ, Corrigan CJ, Bradley B, Durham SR, Collins JV, Jeffrey PK, Quint DJ, Kay AB (1991) Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 87: 1541–1546.
Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan CJ, Durham SR, Kay AB (1992) Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. New Engl J Med 326: 295–304.
Del Prete GF, De Carli M, D’Elios MM, Maestrelli P, Ricci M, Fabbri L, Romagnani S (1993) Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur J Immunol 23: 1445–1449.
Robinson D, Hamid Q, Bentley A, Ying S, Kay AB, Durham SR (1993) Activation of CD4+ T-cells, increased Th2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 92: 313–324.
Varney VA, Hamid Q, Gaga M, Ying S, Jacobson M, Frew AJ, Kay AB, Durham SR (1993) Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 92: 644–651.
Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT (1993) Allergen immunotherapy decreases interleukin 4 production in CD4+ T-cells from allergic individuals. J Exp Med 178: 2123–2130.
Jutel M, Pichler WJ, Skrbic D, Urwyler A, Dahinden C, Muller UR (1995) Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-y secretion in specific allergen-stimulated T-cell cultures J Immunol 154: 4187–4194.
Capron M, Bianchi B, D’Elios HH, DeCarli H, Ameolei A, Fabbri, P (1997) In vivo relevance of CD30 in atopic dermatitis. Allergy 52: 1063–1070.
Holt PG, Oliver J, McMenamin C, Bilik N, Kraal G, Thepen T (1993) The antigen presentation functions of lung dendritic cells are downmodulated in situ by soluble mediators from pulmonary alvelolar macrophages. J Exp Med 177: 397–402.
Renz H, Saloga J, Bradley KL, Loader JE, Greenstein JL, Larsen G, Gelfand EW (1993) Specific VT cell subsets mediate the immediate hypersensitivity response to ragweed allergen. J Immunol 151: 1907–1917.
Swain SL (1993) IL-4 dictates T-cell differentiation. Res Immunol 144: 616–620.
Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni M-P, Santoni-Rugiu F, De Carli M, Ricci M, Romagnani S (1992) Reciprocal regulatory role of IFN-y and IL-4 on the in vitro development of human Thl and Th2 clones. J Immunol 148: 2142–2147.
Kopf M, Le Gros G, Bachmann M, Lamers MC, Bluthmann H, Kohler G (1993) Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362: 245–248.
Piccinni M-P, Macchia D, Parronchi P, Giudizi M-G, Bani D, Aterini R, Grossi A, Ricci M, Maggi E, Romagnani S (1991) Human bone marrow non-B, non-T-cells produce interleukin-4 in response to cross-linkage of Fc and Fc receptors. Proc Natl Acad Sci USA 88: 8656–8660.
Bradding P, Feather IH, Howarth PH, Mueller R, Roberts JA, Britten K, Bews JPA, Hunt TC, Okayama Y, Heusser CH, Bullock GR, Church MK, Holgate ST (1992) Interleukin 4 is localized and released by human mast cells. J Exp Med 176: 1381–1386.
Brunner T, Heusser CH, Dahinden CA (1993) Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. J Exp Med 177: 605–611.
MacGlashan D, White JM, Huang S-K, Ono SJ, Schroeder JT, Lichtenstein LM (1994) Secretion of IL-4 from human basophils: the relationship between IL-4 mRNA and protein in resting and stimulated basophils. J Immunol 152: 3006–3016.
Okayama Y, PettéFrère C, Kassel O, Semper A, Quint D, Tunon-de-Lara MJ, Bradding P, Holgate ST, Church MK (1995) IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells. J Immunol 155: 1796–1808.
Moqbel R, Ying S, Barkans J, Newman TM, Kimmitt P, Vakelin M, Taborda-Barata L, Meng Q, Corrigan CJ, Durham SR, Kay AB (1995) Identification of mRNA for interleukin-4 in human eosinophils with granule localization and release of the translated product. J Immunol 155: 4939–4947.
Yashimoto T, Paul WE, (1994) CD4pos, NK1.lpos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med 179: 1285–1295.
Pfeiffer C, Stein J, Southwood S, Ketelaar H, Sette A, Bottomly K (1995) Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J Exp Med 181: 1569–1574.
Kalinski P, Hilkens CMU, Wierenga EA, van der Pouw-Kraan TCTM, van Lier RAW, Bos JD, Kapsenberg ML, Snijdewint FGM (1995) Functional maturation of human naive T helper cells in the absence of accessory cells: generation of IL-4-producing T-helper cells does not require exogenous IL-4. J Immunol 154: 3753–3760.
Demeure CE, Yang LP, Byun DG, Ishihara H, Vezzio N, Delespesse G (1995) Human naive CD4 T-cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions. Eur J Immunol 25: 2722–2725.
Croft M, Swain SL (1995) Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T-helper 2-type cytokines. J Immunol 154: 4269–4282.
Wershil BK, Theodos CM, Galli SJ, Titus RG (1994) Mast cells augment lesion size and persistence during experimental leishmania major infection in the mouse. J Immunol 152: 4563–4571.
Schmitz J, Thiel A, Kuhn R, Rajewsky K, Muller W, Assenmacher M, Radbruch A (1994) Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-T Cells. J Exp Med 179: 1349–1353.
Finkelman FD, Urban JF (1992) Cytokines: making the right choice. Parasitol Today 8: 311–314.
Bendelac A, Killeen N, Littman DR, Schwartz RH (1994) A subset of CD4+ thymocytes selected by MHC class I molecules. Science 263: 1774–1778.
Yashimoto T, Bendelac A, Watson C, Hu-Li J, Paul WE (1995) CD-1-specific, NK1.1P°S T-cells play a key in vivo role in a Th2 response and in IgE production. Science 270: 1845–1847.
Yoshimoto T, Bendelac A, Hu-Li J, Paul WE (1995) Defective IgE production by SJL mice is linked to the absence of a subset of T-cells that promptly produce IL-4. Science 270: 1845–1847.
Mingari, M-C, Maggi E, Cambiaggi A, Annunziato F, Schiavetti F, Manetti R, Moretta L, Romagnani S (1996) In vitro development of human CD4+ thymocytes into functionally mature Th2 cells. Exogenous IL-12 is required for priming thymocytes to the production of both Thl cytokines and IL-10. Eur J Immunol 26: 1083–1086.
Del Prete, G-F, Maggi E, Parronchi P, Chretien I, Tiri A, Macchia D, Ricci M, Romagnani S (1988) IL-4 is an essential factor for the IgE synthesis induced in vitro by human T-cell clones and their supernatants. J Immunol 140: 4193–4198.
Punnonen J, Aversa G, Cocks BG, McKenzie ANJ, Menon S, Zurawski G, de Waal Malefyt R, de Vries JE (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 90: 3730–3734.
Parronchi P, De Carli M, Manetti R, Simonelli C, Piccinni M-P, Macchia D, Maggi E, Del Prete G-F, Ricci M, Romagnani S (1992) Aberrant interleukin (IL)-4 and IL-5 production in vitro by CD4+ helper T-cells from atopic subjects. Eur J Immunol 22: 1615–1620.
Parronchi P, Sampognaro S, Annunziato F, Brugnolo F, Radbruch A, DiModugno F, Ruffilli A, Romagnani S, Maggi E (1998) Influence of both T cell receptor repertoire and severity of the atopic status on the cytokine secretion profile of Parietaria officinalis-specific T cells. Eur J Immunol (In Press).
Marsh DG, Lockhart A, Holgate ST (1993) The Genetics of Asthma. Blackwell Scientific Publications, Oxford.
Moffatt MF, Hill MR, Cornelis F, Schou C, Faux JA, Young RP, James AL, Ryan G, le Souef P, Musk AW, Hopkin JM, Cookson WOCM (1994) Genetic linkage of T-cell receptor a/d complex to specific IgE response. Lancet 343: 1597–1600.
Mohapatra SS, Mohapatra S, Yang M, Ansari AA, Parronchi P, Maggi E, Romagnani S (1994) Molecular basis of cross-reactivity among allergen-specific human T-cells: T-cell receptor V gene usage and epitope structure. Immunology 81: 15–20.
Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, Schou C, Krishnaswamy G, Beaty TH (1994) Linkage analysis of IL-4 and other chromosome 5g31.1 markers and total serum immunoglobulin E concentrations. Science 264: 1152–1156.
Murphy KM, Murphy IL, Gold JS, Szabo SJ (1993) Current understanding of IL-4 gene regulation in T cells. Res Immunol 144: 575–578.
Matsuda I, Nato Y, Arai K, Arai N (1993) The structure of IL-4 gene and regulation of its expression. Res Immunol 144: 569–574.
Parronchi P, De Carli M, Manetti R, Simonelli C, Sampognaro, S, Piccinni M-P, Macchia D, Maggi E, Del Prete G-F, Romagnani S (1992) IL-4 and IFN(s) (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Thl or Th2 human T-cell clones. J Immunol 149: 2977–2982.
Parronchi P, Mohapatra S, Sampognaro S, Giannarini L, Wahn U, Chong P, Mohapatra SS, Maggi E, Renz H, Romagnani S (1996) Modulation by IFN-a of cytokine profile, T cell receptor repertoire and peptide reactivity of human allergen-specific T-cells. Eur J Immunol 26: 697–703.
Chehimi J, Trinchieri G (1994) Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency. J Clin Immunol 14: 149–161.
Manetti R, Parronchi P, Giudizi M-G, Piccinni M-P, Maggi E, Trinchieri G, Romagnani S (1993) Natural killer cell stimulatory factor (interleukin 12) induces T-helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 177: 1199–1204.
Hsieh C-S, Macatonia SE, Tripp CS, Wolf SF O’Garra A, Murphy KM (1993) Development of TH1 CD4+ T-cells through IL-12 produced by Leisteria-induced macrophages. Science 260: 547–49.
Kemeny M (1993) The role of CD8+ T-cells in the regulation of IgE. Clin Exper Allergy 23: 466–470.
McMenamin C, Holt PG (1993) The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T-cell-mediated but MHC class-II-restricted CD4+ T-cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J Exp Med 178: 889–899.
McMenamin C, McKersey M, Kühnlein P, Hünig T, Holt PG (1997) yS T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens. J Immunol 154: 4390–4394.
Tepper RI, Levinson DA, Stonger BL, Campos-Torres J, Abbas AK, Leder P (1990) IL-4 induces allergic-like inflammatory disease and alters T-cell development in transgenic mice. Cell 62: 457–467.
Varney VA, Jacobson MR, Sudderinck MR, Robinson DS, Irani A-MA, Scwartz LB, Mackay IS, Kay AB, Durham SR (1992) Immunohistology of the nasal mucosa following allergen-induced rhinitis: identification of activated T-lymphocytes, eosinophils and neutrophils. Am Rev Respir Dis 146: 170–176.
Durham SR, Ying S, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, Kay AB, Hamid QA (1992) Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J Immunol 148: 2390–2394.
Bradding P, Feather IH, Wilson S, Bardin PG, Heusser CH, Holgate ST, Howarth PH (1993) Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects: the mast cells as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J Immunol 151: 3853–3860.
Drazen JM, Arm JP, Austen KF (1996) Sorting out the cytokines of asthma. J Exp Med 183: 1–5.
Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB (1988) Eosinophils and mast cells in bronchoalveolar lavage in mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 137: 62–69.
Azzawi M, Bradley B, Jeffery PK, Frew AJ, Wardlaw AJ, Knowles GK, Assoufi B, Collins JV, Durham SR, Kay AB (1990) Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 142: 1407–1413.
Kay AB, Ying S, Varney V, Gaga M, Durham SR, Moqbel R, Wardlaw AJ, Hamid Q (1991) Messenger RNA expression of the cytokine gene cluster interleukin-3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase reactions in atopic subjects. J Exp Med 173: 775–778.
Robinson D, Hamid Q, Ying S, Bentley A, Assoufi B, Durham SR, Kay AB (1993) Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-y cytokine gene expression. Am Rev Respir Dis 148: 401–406.
Mori A, Suko M, Nishizaki Y, Kaminuma O, Kobayashi S, Matsuzaki G, Yamamoto K, Ito K, Tsuruoka N, Okudaira H (1995) IL-5 production by CD4+ T cells of asthmatic patients is suppressed by gluocorticoids and the immunosuppressants FK506 and cyclosporin A. Intern Immunol 7: 449–457.
Leung DYM, Martin RJ, Szefler SJ, Sher ER, Kay AB, Hamid Q (1995) Dysregulation of interleukin-4, interleukin-5, and interferon-y gene expression in steroid-resistant asthma. J Exp Med 181: 33–40.
Ying S, Durham SR, Corrigan CJ, Hamid Q, Kay AB (1995) Phenotype of cells expressing mRNA for Th2-type (interleukin-4 and interleukin-5) and Th1-type (interleukin-2 and interferon-y) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am J Respir Cell Mol Biol 12: 477–487.
Tang MLK, Coleman J, Kemp AS (1995) Interleukin-4 and interferon-gamma production in atopic and non-atopic children with asthma. Clin Exp Allergy 25: 515–521.
Corrigan CJ (1995) Elevated interleukin-4 secretion by T lymphocytes: a feature of atopy or asthma? Clin Exp Allergy 25: 485–487.
Walker C, Bode E, Boer L, Hansel TI’, Blaser K, Virchow J-C (1992) Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 146: 109–115.
Till S, Li B, Durham SR, Humbert M, Assoufi B, Huston D, Dickinson R, Jeannin P, Kay AB, Corrigan C (1995) Secretion of the eosinophil-active cytokines interleukin-5, granulocyte/macrophage colony-stimulating factor and interleukin-3 by bronchoalveolar lavage CD4+ and CD8+ T cell lines in atopic asthmatics, and atopic and non-atopic controls. Eur J Immunol 25: 2727–2731.
Zachary CB, MacDonald DM (1983) Quantitative analysis of T lymphocyte subsets in atopic eczema, using monoclonal antibodies and flow cytometry. Br J Dermatol 108: 411–422.
Sillevis Smitt JH, Bos JD, Hulsebosch HJ, Krieg SR (1986) In situ immunophenotyping of antigen presenting cells and T cell subsets in atopic dermatitis. Clin Exper Dermatol 11: 159–168.
Tang M, Kemp A (1994) Production and secretion of interferon-gamma in children with atopic dermatitis. Clin Exp Immunol 95: 66–72.
Kimata H, Fujimoto M, Furusho K (1995) Involvement of interleukin (IL)-13, but not IL-4, in spontaneous IgE and IgG4 production in nephrotic syndrome. Eur J Immunol 25: 1497–1501.
Tang MLK, Varigos G, Kemp AS (1994) Reduced interferon-gamma (IFN-y) secretion with increased IFN-y mRNA expression in atopic dermatitis: evidence for a post-transcriptional defect. Clin Exp Immunol 97: 483–490.
Lester MR, Hofer MF, Gately M, Trumble A, Leung DYM (1995) Down-regulating effects of IL-4 and IL-10 on the IFN-y response in atopic dermatitis. J Immunol 154: 6174–6181.
Reinhold U, Kukel S, Goeden B, Neumann C, Kreysel HW (1991) Functional characterization of skin-infiltrating lymphocytes in atopic dermatitis. Clin Exp Immunol 86: 444–448.
Van Reijsen FC, Bruijnzeel-Koomen CAFM, Kalthoff FS, Maggi E, Romagnani S, Westland JKT, Mudde GC (1992) Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis. J Allergy Clin Immunol 90: 184–192.
Sager N, Feldmann A, Schilling G, Kreitsch P, Neumann C (1992) House dust mite-specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patch test. J Allergy Clin Immunol 89: 801–810.
Virtanen T, Maggi E, Manetti R, Piccinni M-P, Sampognaro S, Parronchi P, De Carli M, Zuccati G, Romagnani S (1995) No relationship between skin-infiltrating Th2-like cells and allergen-specific IgE response in atopic dermatitis. J Allergy Clin Immunol 96: 411–420.
Ohmen JD, Hanifin JM, Nickoloff BJ, Rea TH, Wyzykowski R, Kim J, Jullien D, McHugh T, Nassif AS, Chan SC, Modlin RL (1995) Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions. J Immunol 154: 1956–1963.
Thepen T, Langeveld-Wildschut EG, Bihari IC, van Wichen DF, van Reijsen FC, Mudde GC, BruijnzeelKoomen, CAFM (1996) Bi-phasic response against aeroallergen in atopic dermatitis showing a switch from an initial Th2 response into a Thl response in situ: an immuno-cytochemical study. J Allergy Clin Immunol 97: 828–837.
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Romagnani, S. (1998). Inflammation. In: Denburg, J.A. (eds) Allergy and Allergic Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2776-0_11
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