Abstract
The purpose of this paper is to consider the nature and the localization of central receptor systems involved in the control of fluid intake. Inherent in a discussion of these topics is a consideration of how such information describing receptor systems is obtained. Two commonly used techniques which are well suited to such analyses are the experimental brain lesion and its variants, and the intracranial chemical injection. Although other techniques can and often are applied to the questions of localization and nature of central systems, it is truly only in experiments that employ the measurement of specific ingestive behavior that such central mechanisms may be directly understood. Other techniques, which may be described as ancillary, do indeed provide relevant information regarding the organization for central behavioral mechanisms; however, it is only by the use of behavior as the dependent measure that a definitive understanding of those brain systems relevant to behavior can be achieved.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. Buggy, A.E. Fisher, W.E. Hoffman, A.K. Johnson, and M.I, Phillips. Ventricular obstruction: effect on drinking induced by intracranial angiotensin. Science 190: 72 (1975).
R.M. Elfont, A.N. Epstein, and A.L.R. Findlay. The role of the subfornical organ in angiotensin-induced drinking in the North American opossum, J. Physiol. (London) 301: 49 (1979).
A.N. Epstein, J.T. Fitzsimons, and B.J. Rolls, Drinking induced by injection of angiotensin into the brain of the rat, J. Physiol. (London), 210: 457 (1970).
D.A. Fitts, R.L. Thunhorst, and J.B, Simpson, Fluid intake, distribution, and excretion during lateral ventricular infusions of carbachol in rats, Brain Res. In press.
D.A. Fitts, R.L. Thunhorst, and J.B. Simpson, Modulation of salt appetite by lateral ventricular infusions of angiotensin II and carbachol, Brain Res. In press.
A.K. Johnson and A.N. Epstein, The cerebral ventricles as the avenue for the dipsogenic action of intracranial angiotensin, Brain Res. 86: 399 (1975).
R.A. Leavitt and A.E. Fisher, Anticholinergic blockade of centrally induced thirst, Science, 154: 520 (1966).
R.W. Lind and A.K. Johnson, Subfornical organ-median preoptic connections and drinking and pressor responses to angiotensin II, Neuroscience, 2: 1043 (1982).
M.L. Mangiapane and J.B. Simpson, Pharmacological independence of subfornical organ receptors mediating drinking, Brain Res. 178: 507 (1979).
M.L. Mangiapane and J.B. Simpson, Subfornical organ: forebrain site of pressor and dipsogenic action of angiotensin II, Amer. J. Physiol. 239: R382 (1980a).
M.L. Mangiapane and J.B. Simpson, Subfornical organ lesions reduce the pressor effect of systemic angiotensin, Neuroendocrinol. 31: 380 (1980b).
M.L. Mangiapane and J.B. Simpson, Drinking and pressor responses after acetylcholine injection into subfornical organ, Amer. J. Physiol. 244: R508 (1983).
R.R. Miselis, The efferent projections of the subfornical organ of the rat: a circumventricular organ within a neural network subserving fluid balance, Brain Res. 230: 1 (1981).
A. Routtenberg, Drinking induced by carbachol: thirst circuit or ventricular modification? Science 157: 838 (1967).
A. Routtenberg, Intracranial chemical injection and behavior; a critical review, Behav. Biol. 7: 601 (1972).
J.B. Simpson, The circumventricular organs and the central actions of angiotensin, Neuroendocrinol. 32: 248 (1981).
J.B. Simpson, A.N. Epstein and J.S. Camardo, The localization of dipsogenic receptors for angiotensin II in the subfornical organ, J. Comp. Physiol. Psychol. 92: 581 (1978).
J.B. Simpson, M. Reed, L.C. Keil, T.N. Thrasher and D.J. Ramsay, Forebrain analysis of vasopressin secretion and water intake induced by angiotensin II, Fed. Proc. 38: 2968 (1979).
J.B. Simpson and A. Routtenberg, The subfornical organ and carbachol induced drinking. Brain Res. 45: 135 (1972)
J.B. Simpson and A. Routtenberg, Subfornical organ: site of drinks ing elicitation by angiotensin II, Science 181: 1172 (1973).
T.N. Thrasher, J.B. Simpson and D. J. Ramsay, Lesions of the subfornical organ block angiotensin drinking in the dog, Neuroendocrinol. 35: 68 (1982).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer Science+Business Media New York
About this chapter
Cite this chapter
Simpson, J.B. (1986). The Nature and Localization of Central Receptor Systems. In: de Caro, G., Epstein, A.N., Massi, M. (eds) The Physiology of Thirst and Sodium Appetite. NATO ASI Series, vol 105. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0366-5_40
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0366-5_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0368-9
Online ISBN: 978-1-4757-0366-5
eBook Packages: Springer Book Archive