Abstract
Many investigations have shown that cardiac tissue is able to produce prostaglandins (PGs) of D, E, F series and over all prostacyclin (1–3) both in animals and in humans. Much evidence indicates that the primary site of PGs synthesis is the coronary vasculature and not the cardiac myocytes (3,4).
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References
P. Needleman, D.L. Kay, P.C. Isakson, et al., Relationship between oxygen tension, coronary vasodilatation and prostaglandins biosynthesis in the isolated rabbit heart. Prostaglandins 9:123–134 (1975).
K. Schrör, S. Moncada, F.B. Ubatuba, and J.R. Vane, Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart. Formation of RCS and prostacyclin. Europ. J. Pharmacol. 47:103–114 (1978).
M. Sivakoff, E. Pure, W. Hsueh, and P. Needleman, Prostaglandins and the heart. Fed. Proc. 38:78–82 (1979).
A. Wennmalm, Prostaglandin-mediated inhibition of noradrenaline release: VI. On the intra-cardiac source of prostaglandins released from isolated rabbit hearts. Acta Physiol. Scand. 105:254–256 (1979).
A.P. Raz, P.C. Isakson, M.S. Minkes, and P. Needleman, Characterization of a novel matabolic pathway of arachidonate in coronary arteries which generates a potent endogenous coronary vasodilator. J. Biol. Chem. 252:1123–1126 (1977).
P. Maurer, M.A. Moskowitz, L. Levine, E. Melamed, The synthesis of prostaglandins by bovine cerebral microvessels. Prostagl. Med. 4:153–161 (1980).
N.A. Terragno, and A. Terragno, Prostaglandin metabolism in the fetal and maternal vasculature. Fed. Proc. 38:75–77 (1979).
H.H. Davis, W.A. Heaton, B.A. Siegel, C.J. Mathias, J.H. Joist, L.A. Sherman, and M.J. Welch, Scintigraphic detection of atherosclerotic lesions and venous thrombi in man by indium111 -labelled autologous platelets. Lancet i:1185–1187 (1978).
P. Mehta, J. Mehta, C.J. Pepine, et al., Platelet aggregation across the myocardial vascular bed in man: normal versus diseased coronary arteries. Thromb. Res. 14:423–432 (1979).
E.F. Ellis, O. Oelz, L.J. Roberts, et al., Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2. Science 193: 1135–1137 (1976).
M. Hamberg, J. Svensson, and B. Samuelsson, Thromboxanes: a new group of biological active compounds derived from prostaglandin endoperoxides. Proc. Natl. Acad. Sci.(Wash.) 72: 2994–2998 (1975).
P. Needleman, P.S. Kulkarni, and A. Raz, Coronary tone modulation: formation and actions of prostaglandins, endoperoxides and thromboxanes. Science 195:409–412 (1977).
Z.I. Terashi, H. Fukui, K. Nishikawa, et al., Coronary vasospastic action of thromboxane A2 in isolated, working guinea pig hearts. Europ. J. Pharmacol. 53:49–56 (1978).
G. Kaley, The role of prostaglandins in vascular homeostasis. Fed. Proc. 35:2358–2359 (1976).
P. Neeldeman, and G. Kaley, Cardiac and coronary prostaglandin synthesis and function. N. Engl. J. Med. 298:1122–1128 (1978).
P. Hedqvist, Actions of prostacyclin (PGI2) on adrenergic neuroeffector transmission in the rabbit kidney. Prosta glandins 17:249–258 (1979).
A.G. Herman, T.J. Verbeuren, S. Moncada, and P.M. Van Houtte, Effects of prostacyclin on myogenic activity and adrenergic neurofactor interaction in canine isolated veins. Prostaglandins 16:911–921 (1978).
G.G. Neri Serneri, E. Silvestrini, P. Paoletti, and G. Masotti, Studi sulle sindromi trombofiliche. V. L’adesivita e 1’aggregazione delle piastrine nella malattia ateromasica. Riv. Clin. Med. 68, (suppl. 6), 47 (1978).
A. Szczeklik, R.J. Gryglewski, J. Musial, L. Grodzinska, M. Serwonska, and E. Marcinkiewicz, Thromboxane generation and platelet aggregation in survivals of myocardial infarction. Thromb. Haem. 40:66 (1978).
P. Mehta, J. Mehta, C.J. Pepine, T.D. Miale, and C. Burger, Platelet aggregation across the myocardial vascular bed in man: normal versus diseased coronary arteries. Thromb. Res. 14:423 (1979).
H.H. Davis, B.A. Siegel, J.H. Joist, W.A. Heaton, C.J. Mathias, L.A. Sherman, and M.J. Welch, Scintigraphic detection of atherosclerotic lesions and venous thrombi in mann by indiunv-111 -labelled autologous platelets. Lancet i:1185 (1978).
M.K. Dewanjee, V. Puster, M. P. Kaye, and M. Josa, Imaging platelet deposition with 111-In-labelled platelets in coronary artery by pass grafts in dogs. Mayo. Clin. Proc. 53:327 (1978).
S. Moncada, E.A. Higgs, and J.R. Vane, Human arterial and venous tissue generate prostacyclin (Prostaglandin X), a potent inhibitor of platelet aggregation. Lancet 1:18 (1977).
S. Moncada, R. Gryglewski, S. Bunting, and J.R. Vane, An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263:633 (1976).
P. Needleman, S.D. Bronson, A. Wyche, M. Sivakoff, and K.G. Nicolau, Cardiac and renal prostaglandin I2 — Biosynthesis and biological effects in isolated perfused rabbit tissues. J. Clin. Invest. 61:839 (1978).
G.G. Neri Serneri, G. Masotti, L. Poggesi, and G. Galanti, Release of prostacyclin into the blood stream and its exhaustion in humans after local blood changes (ischemia and venous stasis). Thromb. Res. 17:197 (1980).
E. Granström, H. Kindahl, and B. Samuelsson, Radioimmunoassay for thromboxane B2. Analyt. Lett. 9:611 (1976).
R.R. Gorman, S.S. Bunting, and O.V. Miller, Modulation of human platelet adenylate cyclase by prostacyclin (PGX). Prostaglandins 13:377 (1977).
E.W. Salzman, Platelets, prostaglandins and cyclic nucleotides. In: Platelets: a multidisciplinary approach. 1st ed., p.227, Editors: G. De Gaetano and S. Garattini, Raven Press, New York, (1978).
J.G. White, and J.M. Gerrard, Platelet morphology and the ultrastructure of regulatory mechanisms involved in platelet activation. In: Platelets: a multidisciplinary approach. 1st ed. p. 17, Editors: G. De Gaetano and S. Garattini, Raven Press, New York, (1978).
M. Minkes, N. Stanford, M.M.Y. Chi, A.R. Roth, P. Needleman, and P.W. Majerus, Cyclic adenosine 3′, 5′-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. J. Clin. Invest. 59:449 (1977).
O.V.V. Miller, and R.R. Gorman, Modulation of platelet cyclic nucleotide content by PGE1 and the prostaglandins endo-peroxide PGG2. J. Clin. Nucl. Res. 2:7 (1976).
O.V. Miller, R.A. Johnson, and R.R. Gorman, Inhibition of PGE1-stimulated cAMP accumulation in human platelets by thromboxane A2. Prostaglandins 13:599 (1977).
R. Korbut, and S. Moncada, Prostacyclin and thromboxane A2 interaction in vivo. Regulation by aspirin and relationship with anti-thrombotic therapy. Thromb. Res. 13:489 (1978).
L.C. Best, T.G. Martin, R.G.G. Russel, and F.E. Preston, Prostacyclin increase cyclic AMP levels and adenylate cyclase activity in platelets. Nature 267:850 (1977).
G.N. Brodie, N.L. Baenziger, L.R. Chase, and P.W. Majerus, The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets. J. Clin. Invest. 51:81 (1972).
S. Niewiarowski, and M. Millman, Potentiation of the thrombin induced platelet release reaction by fibrin. Thromb Res. 9:181 (1976).
G.G. Neri Serneri, R. Abbate, G.F. Gensini, C. Mugnaini, and A. Lagi, Occurrence of a plasmatic platelet aggregating activity in some patients with increased platelet aggregation, In: Advances in Coagulation, Fibrinolysis, Platelet Aggregation and Atherosclerosis, 1st ed., p. 396, Editor A. Strano, C.E.P.I. Roma (1976).
G.G. Neri Serneri, R. Abbate, C. Mugnaini, and G.F. Gensini, Increased platelet aggregation due to a plasma aggregating activity. Identification of the responsible factors. Haemostasis 8 (in press) (1979).
V. Hofmann, and P.W. Straub, A radioimmunoassay technique for the rapid measurement of human fibrinopeptide A. Thromb. Res. 11:71 (1977).
G.G. Neri Serneri, R. Abbate, G.F. Gensini, L. Poggesi, G. Masotti, S. Favilla, C. Mugnaini, and G. Galanti, Prostacyclin and thromboxane release in plasma after adrenergic stimulation. In: Myocardial Infarction, edited by D.T. Mason, G.G. Neri Serneri, M.F. Oliver, pp. 383–387, Excerpta Medica, Amsterdam (1979).
G.G. Neri Serneri, G. Masotti, L. Poggesi, R. Abbate, and M. Mannelli, Prostacyclin and thromboxane A2 formation in response to adrenergic stimulation in humans. A mechanism for local control of vascular response to sympathetic activation? Card. Res.(In press) (1981).
G.G. Neri Serneri, G. Masotti, L. Poggesi, G. Galanti, A. Morettini, and L. Scarti, Reduced prostacyclin production in patients with different manifestations of ischemic heart disease. Am. J. Cardiol. (In press) (1981).
M.J. Armstrong, G. Thirsk, and J.A. Salmon, Effects of prostacyclin (PGI2), 6-oxo-PGF1α and PGE2 on sympathetic nerve function in mesenteric arteries and veins of the rabbit in vitro. Hypertension 1:309–315 (1979).
H. Jasue, S. Tanaka, and F. Akiyama, Prinzmetal’s variant form of angina as a manifestation of alpha-adrenergic receptor-mediated coronary artery spasm: documantation by coronary arteriography. Am. Heart J. 91:148–155 (1976).
D.L. Levene, and M.R. Friedman, Alpha-adrenoceptor-mediated coronary artery spasms. JAMA 236:1018–1022 (1976).
D.R. Ricci, A.E. Orlick, P.R. Cipriano, D.F. Guthaner, and D.C. Harrison, Altered adrenergic activity in coronary arterial spasm. Insight into a mechanism based on study of coronary hemodynamics and the electrocardiogram. Am. J. Cardiol. 43:1073–1079 (1979).
J.D. Folts, E.B. Crowell, and G.G. Rowe, Platelet aggregation in partially obstructed vessels and its elimination by aspirin. Circulation 54:365 (1976).
L.D. Hills, and E. Braunwald, Coronary-artery spasm. N. Engl. J. Med. 299, 695 (1978).
G.H. Mudge, R.H. Grossman, R.H. Jr. Mills, M. Lesch, and E. Braunwald, Reflex increase in coronary vascular resistance in patients with ischemic heart disease. N. Engl. J. Med. 295:1333 (1976).
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Neri Serneri, G.G. et al. (1984). Role of Prostacyclin and Thromboxane A2 in Ischaemic Heart Disease. In: Strano, A. (eds) Thrombosis and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 164. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8616-2_18
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DOI: https://doi.org/10.1007/978-1-4684-8616-2_18
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