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Aspects of Eicosanoids in Inflammation

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Prostanoids and Drugs

Part of the book series: NATO ASI Series ((NSSA,volume 177))

Abstract

The microvascular system has a key role in host defence and expression of the inflammatory process which is indispensible for the elimination of foreign and noxious agents. Regardless of the nature of the initiating stimulus, the sequence of microvascular events in early inflammation is with few exceptions characterized by the following partly overlapping reactions; (i) changes in arteriolar diameters and blood flow, (ii) increased venular permeability promoting macromolecular leakage and formation of tissue edema, and (iii) diapedesis and migration of leukocytes into the area of injury. It is also becoming increasingly clear that the waxing and waning of the inflammatory process, rather than being a static phenomenon, is the result of a continuous interplay between mediators, modulators, and feed back mechanisms.

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Author information

Authors and Affiliations

  1. Department of Physiology and the Institute of Environmental Medicine, Karolinska Institutet, S-104 01, Stockholm, Sweden

    Per Hedqvist, Sven-Erik Dahlén, Johan Raud & Lennart Lindbom

  2. Department of Pharmacology, University of Mississippi Medical Center, Jackson, MS, 39216, USA

    Åsa Thuresson-Klein

  3. Department of Toxicology, University of Mississippi Medical Center, MS, 39216, USA

    Åsa Thuresson-Klein

  4. Department of Organic Chemistry, University of Pennsylvania, Philadelphia, PA, 191 04, USA

    K. C. Nicolaou

Authors
  1. Per Hedqvist
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  2. Sven-Erik Dahlén
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  3. Johan Raud
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  4. Lennart Lindbom
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  5. Åsa Thuresson-Klein
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  6. K. C. Nicolaou
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Editor information

Editors and Affiliations

  1. Karolinska Institute, Stockholm, Sweden

    B. Samuelsson

  2. University of Milan, Milan, Italy

    F. Berti

  3. University of Parma, Parma, Italy

    G. C. Folco

  4. University of Verona, Verona, Italy

    G. P. Velo

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© 1989 Plenum Press, New York

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Hedqvist, P., Dahlén, SE., Raud, J., Lindbom, L., Thuresson-Klein, Å., Nicolaou, K.C. (1989). Aspects of Eicosanoids in Inflammation. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Prostanoids and Drugs. NATO ASI Series, vol 177. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7938-6_19

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  • DOI: https://doi.org/10.1007/978-1-4684-7938-6_19

  • Publisher Name: Springer, New York, NY

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