Abstract
Contrary to the currently popular belief, genes (flanking and internal noncoding sequences included) that specify beta-sheet and alpha-helical proteins are not unique sequences, rather they are degenerate repeats of short primordial building block sequences that are 45 to 48 bases long in the case of genes belonging to the beta-2-microglobulin superfamily. Accordingly, a large number of base decamers, nonomers, octamers, heptamers and hexamers recur within every gene.
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© 1985 Plenum Press, New York
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Ohno, S. (1985). The Notion of Primordial Building Blocks in Construction of Genes and Transcriptional and Processing Errors Due to Random Occurrence of Oligonucleotide Signal Sequences. In: Salk, D., Fujiwara, Y., Martin, G.M. (eds) Werner’s Syndrome and Human Aging. Advances in Experimental Medicine and Biology, vol 190. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7853-2_34
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DOI: https://doi.org/10.1007/978-1-4684-7853-2_34
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