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Melatonin Interaction with the Benzodiazepine-GABA Receptor Complex in the CNS

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Kynurenine and Serotonin Pathways

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 294))

Abstract

The major inhibitory neurotransmitter, γ-aminobutyric acid (GABA) acts on a postsynaptic receptor complex which includes GABA and benzodiazepine (BZ) recognition sites and a chloride ionophore (Turner and Whittle, 1983). Pharmacological, biochemical and neurophysiological studies suggest that BZ agonists, such as diazepam, exert their central effects by enhancing lowaffinity GABA binding (DeFeudis, 1983; Olsen and Venter, 1986).

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© 1991 Plenum Press, New York

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Niles, L. (1991). Melatonin Interaction with the Benzodiazepine-GABA Receptor Complex in the CNS. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_24

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  • DOI: https://doi.org/10.1007/978-1-4684-5952-4_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5954-8

  • Online ISBN: 978-1-4684-5952-4

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