Skip to main content

A Study of Prognostic Factors in Motor Neuron Disease

  • Chapter
Amyotrophic Lateral Sclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 209))

Abstract

Latest advances in the study of motor neuron disease (MND) have pointed out some differences in the course of the illness; subgroups of patients with different survival experience have been identified. A review of studies based on survival analysis is reported in Table 1. It shows the 5-year survival variable from 10 to 50%. Few reports have been devoted to an extensive study of prognostic factors in MND[2, 14, 20, 23]. Age and clinical type at diagnosis are generally considered to influence the course of the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J. Berkson, Limitations of the application of four-fold table analysis to hospital data, Biometrics Bull., 2: 47ā€“53 (1946).

    ArticleĀ  CASĀ  Google ScholarĀ 

  2. J. T. Caroscio, W. F. Calhoum, and N. D. Yahr, Prognostic factors in motor neuron disease: a prospective study of longevity, in: F. Clifford Rose, ed., ā€œResearch Progress in Motor Neuron Disease,ā€ Pitman, London, pp. 34ā€“43 (1984).

    Google ScholarĀ 

  3. A. ChiĆ³, F. Brignolio, M. Leone, P. Mortara, M. G. Rosso, A. Tribolo, and D. Schiffer, A survival analysis of 155 cases of progressive muscular atrophy, Acta Neurol.Scand., 72: 401ā€“413 (1985).

    Google ScholarĀ 

  4. M. Dalakas, G. Elder, and J. Sever, A 9-year follow-up study of patients with late postpoliomyelitis muscular atrophy (PPMA), Neurology, 35 (1): 108 (1985).

    ArticleĀ  Google ScholarĀ 

  5. W. D. Dixon, M. B. Brown, L. Engleman, J. W. Frane, M. A. Hill, R. I. Jennrich, and J. D. Toporek, eds., ā€œBMDP Statistical Software,ā€ University of California Press, Los Angeles (1983).

    Google ScholarĀ 

  6. L. Forsgren, B. G. L. Almay, G. Holmgren, and S. Wall, Epidemiology of motor neuron disease in Northern Sweden, Acta Neurol.Scand., 68: 20ā€“29 (1983).

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  7. S. Gimenez-RoldĆ”n and A. Esteban, Esclerosis lateral amiotrĆ³fica familial. Critica de su clasificaciĆ³n y anĆ”lisis de 14 familias de origen espagnol, Rev.Clin.Esp., 148: 167ā€“173 (1978).

    PubMedĀ  Google ScholarĀ 

  8. L. G. Gunnarsson and R. Palm, Motor neuron disease and heavy manual labor: an epidemiologic survey of Varmland county, Sweden, Neuroepid., 3: 195ā€“206 (1984).

    ArticleĀ  Google ScholarĀ 

  9. C. H. Hawkes, J. B. Cavanagh, S. Mowbray, and E. A. Paul, Familial motor neuron disease: report of a family with 5 post-mortem studies, in: ā€œResearch Progress in Motor Neuron Disease,ā€ F. Clifford Rose, ed., Pitman, London, pp. 70ā€“98 (1984).

    Google ScholarĀ 

  10. K. Kondo and I. Hemmi, Clinical statistics in 515 fatal cases of motor neuron disease, Neuroepid., 3: 129ā€“148 (1984).

    ArticleĀ  Google ScholarĀ 

  11. O. Kristensen and B. Melgaard, Motor neuron disease, Prognosis and epidemiology, Acta Neurol.Scand., 56: 299ā€“308 (1977).

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  12. S. M. Juergens, L. T. Kurland, H. Okazaki, and D. W. Mulder, ALS in Rochester, Minnesota, 1925-1977, Neurology, 30: 463ā€“470 (1980).

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  13. P. Mortara, D. Bardelli, M. Leone, and D. Schiffer, Prognosis and clinical varieties of ALS disease, Ital.J.Neurol.Sei., 2: 237ā€“242 (1981).

    ArticleĀ  CASĀ  Google ScholarĀ 

  14. P. Mortara, A. Chio, M. G. Rosso, M. Leone, and D. Schiffer, Motor neuron disease in the province of Turin, Italy, 1966-1980, Survival analysis in an unselected population, J.Neurol.Sei., 66: 165ā€“173 (1984).

    ArticleĀ  CASĀ  Google ScholarĀ 

  15. D. W. Mulder, R. A. Rosenbaum, and D. Layton, Jr., Late progression of poliomyelitis or forme fruste amyotrophic lateral sclerosis? Mayo Clinic Proc., 47: 756ā€“761 (1972).

    CASĀ  Google ScholarĀ 

  16. D. W. Mulder and F. M. Howard Jr., Patient resistance and prognosis in amyotrophic lateral sclerosis, Mayo Clinic Proc., 51: 537ā€“541 (1976).

    CASĀ  Google ScholarĀ 

  17. K. Murros and R. Fogelholm, Amyotrophic lateral sclerosis in Middle Finland: an epidemiological study, Acta Neurol.Scand., 67: 41ā€“47 (1983).

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  18. F. H. Norris, Adult spinal motor neuron disease, in: ā€œHandbook of Clinical Neurology,ā€ P. J. Vinken and G. W. Bruyn, eds., vol.22, System Disorders and Atrophy, North-Holland, Amsterdam, pp. 1ā€“56.

    Google ScholarĀ 

  19. R. Peto, M. C. Pike, P. Armitage, N. E. Breslow, D. R. Cox, S. V. Howard, N. Mantel, K. MacPherson, J. Peto, and P. G. Smith, Design and analysis of randomized clinical trials requiring prolonged observation of each patient analysis and example, Brit.J.Cancer, 35: 1ā€“39 (1977).

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  20. A. D. Rosen, Amyotrophic lateral sclerosis. Clinical features and prognosis, Arch.Neurol., 35: 638ā€“642 (1978).

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  21. SAS userā€™s guide: basics, SAS Institute Inc., Cary, N.C. (1982).

    Google ScholarĀ 

  22. R. L. Swank and T. J. Putnam, Amyotrophic lateral sclerosis and related conditions. A clinical analysis, Arch.Neurol.Psych., 49: 151ā€“177 (1943).

    ArticleĀ  Google ScholarĀ 

  23. Y. Uebayashi, Y. Yase, H. Tanaka, Y. Shimada, and Y. Toyokura, Prognosis of motor neuron disease in Japan, Neuroepid., 2: 243ā€“256 (1983).

    ArticleĀ  Google ScholarĀ 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

Ā© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Schiffer, D., Brignolio, F., ChiĆ³, A., Leone, M., Rosso, M.G. (1987). A Study of Prognostic Factors in Motor Neuron Disease. In: Cosi, V., Kato, A.C., Parlette, W., Pinelli, P., Poloni, M. (eds) Amyotrophic Lateral Sclerosis. Advances in Experimental Medicine and Biology, vol 209. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5302-7_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5302-7_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5304-1

  • Online ISBN: 978-1-4684-5302-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics