Abstract
The proximal tubule of the kidney is the site of several important physiological processes including the reabsorbtion of inorganic phosphate from the glomerular filtrate and the production of glucose from intermediate metabolites. The phosphate reabsorption performed by the kidney seems to be the major controlling factor in m aintaining overall phosphate homeostasis.
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References
Dennis, V. W., Stead. W. W., Myers, J. L., Renal handling of phosphate and calcium, Annu. Rev. Physiol 41: 257–271 (1979)
Jacobson, H. R., Functional segmentation of the mammalian nephron, Am. J. Physiol. 241: F203–218 (1981)
Watford, M., Hod, Y., Chiao, Y-B., Utter, M. F. Hanson, R. W., The unique role of the kidney in gluconeogensesis in the chicken, J. Biol. Chem. 256: 10023–10027 (1981)
Wirthensohn, G., Vandewalle, A. Guder, W. G., Renal glycerol m etabolis m and the distribution of glycerol kinase in rabbit nephron, Biochem. J. 198: 543–549 (1981)
Guder, W. G. Rupprecht, A., Metabolism of isolated kidney tubules. Independent actions of catechola mines on renal cyclic adenosine 3’-5’-monophosphate levels and gluconeogenesis, Eur. J. Biochem. 52: 283–290 (1975)
Kempson, S. A., Colon-Otero, G., Lise0u, S-Y., Turner, S. T. Dousa, T. P., Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat, J. Clin. Invest. 67: 1347–1360 (1981)
Berndt, T. J., Knox, F. G., Kempson, S. A. Dousa, T. P., Nicotina wide adenine dinucleotide and renal response to parathyroid hormone, Endocrinology 108: 2005–2007 (1981)
Turner, S. T., Kiebzak, G. M. Dousa, T. P., Mechanism of glucocorticoid effect on renal transport of phosphate, Am. J. PhysioL 243: C227 - C236 (1982)
Grahn, M. F. Butterworth, P. J., Modulation of phosphate accumulation in isolated chick kidney cells by gluconeogenic substrates, Bioscience Rep. 2: 661–666 (1982)
Beck, J. C. Sacktor, B., The sodium electrochemical potential.-mediated uphill transport of D-glucose in renal brush border membrane vesicles, J. B.ol. Chem. 253: 5531–5535 (1978)
Bergmeyer, H. U. Bernt, E., Glucose determination with glucose oxidase and peroxidase, in: “Methods of Enzymatic Analysis”, Bergmeyer, H. U., ed., Academic Press,N.Y. (1974)
Nelson, N., A photometric adaptation of the Somogyi method for the determination of glucose, J. Biol. Chem. 153: 375–380 (1944)
Lowry, 0. H., Rosebrough, N. J., Farr, A. L. Randall, R. J., Protein measurement with Folin phenol reagent, J. BioL Chem. 193: 265–275 (1951)
Grahn, M. F. Butterworth, P. J., Phosphate uptake by proximal tubule cells isolated from chick kidney, Biochem. Soc. Trans. 9: 465–466 (1981)
Barrett, P. Q. Aronson, P. S., Glucose and alanine inhibition of phosphate transport in renal microvillus membrane vesicles, Am. J. Physiol. 242: F126 - F131 (1982)
Browne, J. L., Sanford, P. A. Smyth, D. H., Transfer and metabolism of citrate, succinate, a-keto-glutarate and pyruvate by hamster small intestine, Proc. R.S.(Lond.)[B] 200: 117–135 (1978)
Gullans, S. R., Brazy, P. C., Soltoff, S. P., Dennis, V. W. M andel, L. J. M etabolic inhibitors: effects on metabolism and transport in the proximal tubule, Am. J. Physiol. 243: F133 - F140 (1982)
Vandewalle, A., Wirthensohn, G., Heidrich, H-G. Guder, W. G., Distribution of hexokinase and phosphoenolpyruvate carboxykinase along the rabbit nephron, Am. J. Physiol. 240: F492 - F500 (1981)
Robinson, B. H. 0 ei, J., 3-M ercaptopicolinic acid; apreferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase, FEBS Lett. 58: 12–15 (1975)
Farese, R. V., Bidot-Lopez, P., Sabir, M. A., Larson, R. E. The phosphatidate-polyphosphoinositide cycle: activation by parathyroid hormone and dibutyryl cyclic AMP in rabbit kidney cortex, Ann. N. Y. Acad. Sci. 372: 539–551 (1981)
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© 1984 Plenum Press, New York
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Grahn, M.F., Parveen, R., Butterworth, P.J. (1984). Biochemical Studies of the Control of Renal Tubular Phosphate Reabsorption. In: Massry, S.G., Maschio, G., Ritz, E. (eds) Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 178. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4808-5_7
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DOI: https://doi.org/10.1007/978-1-4684-4808-5_7
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