Abstract
Ouabain, a specific inhibitor of Na+K+ ATPase, has been shown to inhibit renin release and exert natriuretic and renal vasoconstrictive effects in the dog (1, 2, 3, 4).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
M. Martínez-Maldonado, M. J. C. Allen, G. Eknoyan, W. Suki and A. Schwartz, Renal concentrating mechanism: Possible role for sodium potassium activated adenosive triphosphatase. Science 165: 807 (1969).
M. Martínez-Maldonado, M. J. C. Allen, C. Inagaki, N. Tsaparas and A. Schwartz, Renal sodium-potassium-activated adenosine triphosphatase and sodium reabsorption. J. Clin. Invest. 51: 2544 (1972).
P. C. Churchill and F. McDonald, Effect of ouabain on renin secretion in anesthetized dogs, J. Physiol. 242: 635 (1974).
M. A. Cruz-Soto, J. E. Benabe, J. M. López-Novoa and M. Martínez-Maldonado, Renal Na+-K+-ATPase in renin release. Am. J. Physiol. 243 (Renal Fluid Electrolyte Physiol. 12): F598 (1982).
L. Belardinelli, D. Harder, N. Sperelakis, R. Rubio and R. M. Berne, Cardiac glycoside stimulation of inward Ca++ current in vascular smooth muscle of canine coronary artery. J. Pharmacol. Exp. Ther. 209: 62 (1979).
P. C. Churchill, Possible mechanism of the inhibitory effect of ouabain on renin secretion from rat renal cortical slices. J. Physiol. London 294: 123 (1979).
C. S. Park, and R. L. Malvin, Calcium in the control of renin release. Am. J. Physiol. 235 (Renal Fluid Electrolyte Physiol.): F22 (1978).
C. S. Park, D. S. Han and J. C. S. Fray, Calcium in the control of renin secretion: Ca2+ influx as an inhibitory signal. Am. J. Physiol. 240 (Renal Fluid Electrolytes Physiol. 9): F70 (1981).
H. J. Lyons, and P. C. Churchill, The influence of ouabain on in vitro renin secretion. Proc. Soc. Exp. Biol. Med. 145: 1148 (1973).
J. M. López-Novoa, J. C. Garcia, M. A. Cruz-Soto, J. E. Benabe, and M. Martínez-Maldonado, Effect of sodium orthovanadate on renal renin secretion in vivo. J. Pharmacol. Exp. Ther. 222: 447 (1982).
M. Martinez-Maldonado, G. Eknoyan, J. C. Allen, W. N. Suki and A. Schwartz, Urine dilution and concentration after digoxin infusion into the renal artery of dogs. Proc. Soc. Exp. Biol. Med. 134: 855 (1970).
M. P. Blaustein, Sodium ions, calcium ions blood pressure regulation, and hypertension: a reassessment and a hypothesis, Am. J. Physiol. 232: C165 (1977).
J. E. Benabe, M. A. Cruz-Soto, and M. Martinez-Maldonado, Critical role of extracellular calcium in vanadate-induced renal vasoconstriction in the dog. Clin. Res. 30 (5): 881A (1982).
W. Hasselback and M. Makinose, ATP and active transport. Biochem. Biophys. Res. Comm. 7: 132 (1982).
A. Schwartz, Calcium and sarcomplasmic reticulum. In: Calcium and the Heart, P. Harris, and L. H. Opie, eds., Academic Press London and New York, (1971).
H. G. Ferreira and V. L. Lew, Use of ionophore A23187 to measure cytoplasmic Ca buffering and activation of the Ca pump by internal Ca. Nature 259: 47 (1976).
H. L. McCrorey, T. Berl, T. J. Burke, A. de Torrente and R. Schrier, Effect of calcium transport inhibitors on renal hemodynamics and electrolytes excretion in the dog. In: Hormonal Regulation of Sodium Excretion. B. Licardus, R. W. Schrier, and J. Ponel, eds. Elsevier/North Holland Biomedical Press, Amsterdam, (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Cruz-Soto, M.A., Martínez-Maldonado, M. (1984). Modification of the Renal Effects of Ouabain by Calcium Channel Blockers. In: Massry, S.G., Maschio, G., Ritz, E. (eds) Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 178. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4808-5_41
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4808-5_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4810-8
Online ISBN: 978-1-4684-4808-5
eBook Packages: Springer Book Archive