Abstract
Since the discovery of cyclic 3′ ,5′-AMP (cAMP) as an intra-cellular mediator in hormone-responsive tissues by E. W. Sutherland (1), it was well recognized that ATP serves as a substrate for the key enzyme of cAMP metabolism—adenylate cyclase (AdC). Later it was also found that ATP may modulate cAMP catabolism by inhibiting cAMP-phosphodiesterase (cAMP-PDIE) (2). However, in recent years little attention was paid to cellular levels of ATP as a potential determinant of hormone-sensitive cAMP metabolism.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
E. W. Sutherland, On the biological role of cyclic AMP, JAMA 214: 1281 (1970).
T. P. Dousa, Cyclic nucleotides in renal pathophysiology, in: “Hormonal Function and the Kidney,” B. Brenner and J. Stein, ed., Churchill Livingstone, New York (1979).
F. Morel, Sites of hormone action in the mammalian nephron. Am. J. Physiol. 240: F159 (1981).
B. A. Jackson, R. M. Edwards, H. Valtin, and T. P. Dousa, Cellular action of vasopressin in medullary tubules of mice with hereditary nephrogenic diabetes insipidus, J. Clin. Invest. 66: 110 (1980).
R. M. Edwards, B. A. Jackson, and T. P. Dousa, ADH-sensitive cAMP system in papillary collecting duct: Effect of osmolality and PGE2, Am. J. Physiol. 240: F311 (1981).
T. P. Dousa, B. A. Jackson, and R. M. Edwards. Cellular action of vasopressin in medullary collecting tubules and in ascending limbs of Henle’s loop, in: “Antidiuretic Hormone,” S. Yoshida, L. Share, and K. Yagi, ed., Japan Scientific Societies Press, Tokyo (1980).
F. Morel, D. Chabardes, and M. Imbert-Teboul, Methodology for enzymatic studies of isolated tubular segments: Adenylate cyclase, in: “Methods in Pharmacology: Renal Pharmacology,” M. Martinez-Maldonado, ed., Plenum Press, New York (1976).
J. J. LeMasters, and C. R. Hackenbrock, Firefly luciferase assay for ATP production by mitochondria, in: “Methods in Enzymology,” M. A. DeLuca, ed., Academic Press, New York (1978).
G. M. Kiebzak, A. N. K. Yusufi, E. Kusano, J. Werness, and T. P. Dousa, Low ATP levels in the proximal convoluted tubule of the mouse nephron, Fed. Proc. 42: 1259 (1983).
M. G. Brunette, D. Chabardes, M. Imbert-Teboul, A. Clique, M. Montegut, and F. Morel, Hormone-sensitive adenylate cyclase along the nephron of genetically hypophosphatemic mice, Kidney Int. 15: 357 (1979).
S. R. Gullans, P. C. Brazy, S. P. Soltoff, V. W. Dennis, and L. J. Mandel, Metabolic inhibitors: Effects on metabolism and transport in the proximal tubule, Am. J. Physiol. 243: F133 (1982).
M. K. Drezner, and W. M. Burch, Altered activity of the nucleotide regulatory site in the parathyroid hormone-sensitive adenylate cyclase from the renal cortex of a patient with pseudohypoparathyroidism, J. Clin. Invest. 62: 1222 (1978).
W. G. Guder, and A. Rupprecht, Hormonal regulation of gluconeogenesis in isolated rat kidney tubule fragments, in: “Use of Isolated Liver Cells and Kidney Tubules in Metabolic Studies,” J. M. Tager, H. D. Soling, and J. R. Williamson, ed., North-Holland Publishing Company, Amsterdam, (1976).
H. B. Burch, S. Choi, C. N. Dence, T. R. Alvey, B. R. Cole, and O. H. Lowry, Metabolic effects of large fructose loads in different parts of the rat nephron, J. Biol. Chem. 255: 8239 (1980).
C. Amiel, D. Chabardes, and C. Bailly. Effects of parathyroid hormone on the kidney: Sites and mechanisms of action, in: “Advances in Nephrology,” J. Hamburger, J. Crosnier, J. Greenfield, and M. Maxwell, ed., Year Book Medical Publishers, Inc., Chicago, (1982).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Dousa, T.P., Kiebzak, G.M., Yusufi, A.N.K., Kusano, E., Braun-Werness, J. (1984). ATP as a Factor in the Response of the cAMP System to PTH in Proximal and Distal Convoluted Tubules. In: Massry, S.G., Maschio, G., Ritz, E. (eds) Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 178. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4808-5_21
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4808-5_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4810-8
Online ISBN: 978-1-4684-4808-5
eBook Packages: Springer Book Archive