Abstract
The blood platelet shares many characteristics in common with synaptosomes, and has been suggested as a model for central serotoninergic neuronal functioning (Murphy et al., 1970; Stahl, 1977). Serotonin (5HT) has been indirectly implicated in the pathophysiology of depression (van Praag and Korf, 1971) and, as such, the uptake of 5HT into the platelet assumes potential importance as a possible indicator of central 5HT uptake activity, as both platelets and synaptosomes share similar Michaelis constants (K m ) for 5HT uptake to the nearest order of magnitude (Stahl and Meltzer, 1978; Smith et al., 1978).
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Rausch, J.L., Shah, N.S., Burch, E.A., Donald, A.G., Munson, E.V. (1984). A Study of Circadian Variation of Platelet Serotonin Uptake and Serum Cortisol in Patients with Major Depression. In: Shah, N.S., Donald, A.G. (eds) Psychoneuroendocrine Dysfunction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4529-9_27
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DOI: https://doi.org/10.1007/978-1-4684-4529-9_27
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