Abstract
Thiazide diuretic agents reduce urine calcium excretion by stimulating distal nephron calcium reabsorption and by reducing extracellular fluid volume (1–3). In patients with idiopathic hy-percalciuria, thiazide administration lowers urinary calcium excretion. In addition, circulating 1,25(OH)2D3 and intestinal calcium absorption rates can also be reduced to normal in those patients with hypercalciuria arising from defective tubular calcium reabsorption (4, 5). Its effects upon serum 1,25(OH)2D3 and intestinal calcium absorption could be due to the reversal of secondary hyperparathyroidism (6). The physiological adaptation to dietary calcium restriction involves an increase in 1,25(OH)2D3 synthesis which, in turn, enhances the intestinal calcium active transport process (7–9). Since this sequence of events is thought to be initiated by an increase in parathyroid hormone (PTH) secretion, we investigated whether thiazide can prevent the intestinal adaptive response to low calcium diet (LCD).
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A.S. Brickman, S.G. Massry and J.W. Coburn, Changes in serum and urinary calcium during treatment with hydrochlorothiazide: Studies on mechanisms, J. Clin. Invest. 51:1879 (1972).
L.S. Constanzo and I.M. Weiner, On the hypocalciuric action of chlorothiazide, J. Clin. Invest. 54:628 (1974).
N. Breslau, A.M. Moses and I.M. Weiner, The role of volume contraction in the hypocalciuric action of chlorothiazide, Kidney Int. 10:l64 (1976).
D.E. Barilla, R. Tolentino, R.A. Kaplan and C.Y.C. Pak, Selective effectives of thiazide on intestinal absorption of calcium in absorptive and renal hypercalciurias, Metabolism 27:125 (1978).
J.E. Zerwekh and C.Y.C. Pak, Selective effects of thiazide therapy on serum la, 25-dihydroxyvitamin D in renal and absorptive hypercalciuria, Metabolism 29:13 (1980).
F.L. Coe, J.M. Canterbury, J.J. Firpo and E. Reiss, Evidence for secondary hyperparathyroidism in idiopathic hypercalciuria, J. Clin. Invest. 52:134 (1973).
R. Nicolaysen, N. Eeg-Larsen and O.J. Malm, Physiology of calcium metabolism, Physiol. Rev. 33:424 (1953).
I.T. Boyle, R.W. Gray and H.F. DeLuca, Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol, Proc. Nat. Acad. Sci. 68:2131 (1971).
M.W. Walling and S.S. Rothman, Apparent increase in carrier affinity for intestinal calcium transport following dietary calcium restriction, J. Biol. Chem. 245:5007 (1970).
M.J. Favus, S.C. Kathpalia, F.L. Coe and A.E. Mond, Effects of diet calcium and 1,25-dihydroxyvitamin D on colon calcium active transport, Am. J. Physiol. 238:G75 (1980).
J.A. Eisman, A.J. Hamstra, B.E. Kream and H.F. DeLuca, A sensitive, precise and convenient method for determination of 1,25-dihydroxy-vitamin D in human plasma, Arch. Biochem. Biophys. 176:235 (1976).
A.B. Schneider, S.A. Wells, J.C. Gunnells, J.B. Leslie and L.M. Sherwood, Regulation of function of transplanted parathyroid glands in man, Am. J. Med. 63:710 (1977).
H.L. Henry, R.J. Midgett, and A.W. Norman, Regulation of 25-hydroxy-vitamin D3–1-hydroxylase in vivo, J. Biol. Chem. 249:7584 (1974).
M.J. Favus, M.W. Walling, and D.V. Kimberg, Effects of dietary calcium restriction and chronic thyroparathyroidectomy on the metabolism of (3H)-25-hydroxyvitamin D3 and active transport of calcium by rat intestine, J. Clin. Invest. 53:1139 (1974).
M.R. Hughes, P.F. Brumbaugh, M.R. Haussler, J.E. Wergedal and D.J. Baylink, Regulation of serum 1α, 25-dihydroxyvitamin D3 by calcium and phosphate in the rat, Science 190:578 (1975).
J.I. Rader, D.J. Baylink, M.R. Hughes, E.F. Safilian and M.R. Haussler, Calcium and phosphorus deficiency in rats: Effects on PTH and 1,25-dihydroxyvitamin D3, Am. J. Physiol. 236:E118 (1979).
M. Garabedian, M.F. Holick, H.F. DeLuca, and I.T. Boyle, Control of 25-hydroxycholecalciferol metabolism by the parathyroid glands, Proc. Nat. Acad. Sci. 69:1673 (1972).
U. Trechsel, J.A. Eisman, J.A. Fischer, J.-P. Bonjour, and H. Fleisch, Calcium-dependent, parathyroid hormone-independent regulation of 1, 25-dihydroxyvitamin D, Am. J. Physiol. 239:E119 (1980).
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Favus, M.J., Coe, F.L., Kathpalia, S.C., Porat, A., Sen, P.K., Sherwood, L.M. (1982). Effects of Chlorothiazide Administration and Dietary Calcium Restriction on Parathyroid Function, Vitamin D Metabolism and Intestinal Calcium Absorption in the Rat. In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_54
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DOI: https://doi.org/10.1007/978-1-4684-4259-5_54
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