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The Use of Mouse X-Autosome Translocations in the Study of X-Inactivation Pathways and Nonrandomness

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Genetic Mosaics and Chimeras in Mammals

Part of the book series: Basic Life Sciences ((BLSC,volume 12))

Abstract

Rearrangements between mammalian X chromosomes and autosomes are valuable tools in the study of X inactivation, since they provide a karyotype in which the physical continuity of the X chromosome is interrupted. In reciprocal X-autosome translocations, T(X;A)’s, there are three chromosomes within each cell of a heterozygote — instead of the usual two — that contain X-chromosome material. This circumstance may be put to use in addressing questions of X-differentiation mechanisms and randomness.

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Authors and Affiliations

  1. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, 37830, USA

    Liane B. Russell & Nestor L. A. Cacheiro

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  1. Liane B. Russell
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  2. Nestor L. A. Cacheiro
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  1. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Liane B. Russell

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Russell, L.B., Cacheiro, N.L.A. (1978). The Use of Mouse X-Autosome Translocations in the Study of X-Inactivation Pathways and Nonrandomness. In: Russell, L.B. (eds) Genetic Mosaics and Chimeras in Mammals. Basic Life Sciences, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3390-6_27

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  • DOI: https://doi.org/10.1007/978-1-4684-3390-6_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3392-0

  • Online ISBN: 978-1-4684-3390-6

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