Abstract
There exist at least two types of kininogens with different molecular weight in mammalian blood plasmas, which are named high molecular weight (HMW) and low molecular weight (LMW) kininogens (1). Although their functions in kallikrein-kinin system remain to be investigated, it has been speculated that HMW kininogen participates in the intrinsic kinin releasing system and Imw kininogen in the extrinsic kinin-releasing system. Quite recently, a new function of kininogen has been suggested by findings of Flaujeac (2), Williams (3), and Fitzgerald (4) traits with a deficiency of kininogen. These plasmas do not release kinin appreciably upon incubation of plasma kallikrein and also has a prolonged activated partial thromboplastin time and inability to form plasmin. These facts suggest the participation of the kininogen in the intrinsic blood coagulation and fibrinolysis, in addition to the kinin-forming system.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Habermann, E. (1970) in: Handbook of Experimental Pharmacology (Erdos, E.G., ed.) pp. 250–288, Springer-Verlag, Berlin-Heidelberg-New York.
Wuepper, K.D., Miller, D.R. and Lacomb, M.J. (1975) Federation Proc. 34, 859.
Colman, R.W., Badasarian, A., Talamo, R.C., Seavey, M., Scott, C.F. and Kaplan, A.P. (1975) Federation Proc. 34, 859.
Saito, H., Ratnoff, O.D., Waldmann, R. and Abraham, J.P. (1975) J. Clin. Invest. 55, 1082–1089.
Komiya, M., Kato, H. and Suzuki, T. (1974) J. Biochem. 76, 811–822.
Komiya, M., Kato, H., and Suzuki, T. (1974) J. Biochem. 76, 833–845.
Komiya, M., Suzuki, T. and Han, Y.N. (1973) Seikagaku (in Japanese) 45, 682.
Han, Y.N., Komiya, N., Iwanaga, S. and Suzuki, T. (1975) J. Biochem. 77, 55–68.
Yano, M., Kato, H., Nagasawa, S. and Suzuki, T. (1967) J. Biochem. 62, 386–388.
Takahashi, H., Nagasawa S. and Suzuki, T. (1972) J. Biochem. 71, 471–483.
Komiya, M., Nagasawa, S. and Suzuki, T. (1972) J. Biochem. 72, 1205–1218.
Iwanaga, S., Sata, T., Mizushima, Y. and Suzuki, T. (1965) J. Biochem. 58, 123–129.
Yano, M., Nagasawa, S. and Suzuki, T. (1971) J. Biochem. 69, 471–481.
Spackman, D.H., Stein, W.H. and Moore, S. (1958) Anal. Biochem. 30, 1190–1206.
Edman, P. (1970) in: Protein Sequence Determination (Needleman, S.B., ed.) pp. 211-255, Springer-Verlag, Berlin.
Bailey, J.L. (1967) in: Techniques in Protein Chemistry, 2nd ed., pp. 163–182, Elsevier, New York.
Braun, V. and Schroeder, W.A. (1967) Arch. Biochem. Biophys. 118, 241–252.
Dubois, M., Gilles, K.A., Hamilton, J.K., Rebers, P.A. and Smity, F. (1956) Anal. Chem. 28, 350–356.
Gardell, S. (1953) Acta Chem. Scand. 7, 207–215.
Warren, L. (1959) J. Biol. Chem. 234, 1971–1975.
Weber, K. and Osborn, M. (1969) J. Biol. Chem. 244, 4406–4412.
Kato, H., Nagasawa, S. and Suzuki, T. (1967) Biochem. Biophys. Res. Communs. 27, 163–168.
Iwanaga, S., Han, Y.N., Komiya, M., Suzuki, T. Katori, N., Ohishi, S. (1975) Life Science 16, 792–793.
Nagasawa, S., Mizushima, Y., Sata, T., Iwanaga, S. and Suzuki, T. (1966) J. Biochem. 60, 643–652.
Goodwin, T.W. and Morton, R.A. (1946) Biochem. J. 40, 628–632.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Kato, H., Han, Y.N., Iwanaga, S., Suzuki, T., Komiya, M. (1976). Bovine Plasma HMW and LMW Kininogens: Isolation and Characterization of the Polypeptide Fragments Produced by Plasma and Tissue Kallikreins. In: Sicuteri, F., Back, N., Haberland, G.L. (eds) Kinins. Advances in Experimental Medicine and Biology, vol 70. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3267-1_18
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3267-1_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3269-5
Online ISBN: 978-1-4684-3267-1
eBook Packages: Springer Book Archive