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A Pharmacokinetic Study of the Combination Rifampicin Plus Trimethoprim in Man

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Pharmacology of Antibiotics

Part of the book series: Chemotherapy ((CT,volume 4))

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Abstract

Previous work in this laboratory (Kerry, Hamilton-Miller and Brumfitt 1975a,b) has shown that a combination of rifampicin (rif) and trimethoprim(tm) will inhibit virtually all common pathogenic bacteria. The combination has the added advantage of acting synergistically against several genera, notably streptococci and all species of proteus. Secondly, it suppresses the emergence of resistance to rifampicin. In view of these encouraging findings, we have now undertaken a pharmacokinetic study to determine whether rif and tm interfere with one another’s handling in man.

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References

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Author information

Authors and Affiliations

  1. The Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG, UK

    W. Brumfitt, V. M. Moss, E. Brooker & J. M. T. Hamilton-Miller

Authors
  1. W. Brumfitt
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  2. V. M. Moss
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  3. E. Brooker
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  4. J. M. T. Hamilton-Miller
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Editor information

Editors and Affiliations

  1. The London Hospital Medical College, London, UK

    J. D. Williams

  2. East Birmingham Hospital, Birmingham, UK

    A. M. Geddes

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© 1976 Plenum Press, New York

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Brumfitt, W., Moss, V.M., Brooker, E., Hamilton-Miller, J.M.T. (1976). A Pharmacokinetic Study of the Combination Rifampicin Plus Trimethoprim in Man. In: Williams, J.D., Geddes, A.M. (eds) Pharmacology of Antibiotics. Chemotherapy, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3123-0_32

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  • DOI: https://doi.org/10.1007/978-1-4684-3123-0_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3125-4

  • Online ISBN: 978-1-4684-3123-0

  • eBook Packages: Springer Book Archive

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