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Structure-Function Relationship of Gastrin Hormones: A Rational Approach to Drug Design

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Bioorganic Chemistry in Healthcare and Technology

Part of the book series: NATO ASI Series ((NSSA,volume 207))

Abstract

The gastrins are a family of gastro-intestinal peptide hormones performing a wide range of biological functions in the digestive process. The sequences of the most common forms of gastrins are the following:

  • pGlu-Leu-Gly-Pro-Gln-Gly-His-Pro-Ser-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly- Pro-Trp-Leu-(Glu)5-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (big gastrin);

  • pGlu-Gly-Pro-Trp-Leu-(Glu)5-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (little gastrin);

  • H-Trp-Leu-(Glu)5-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (minigastrin).

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References

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© 1991 Plenum Press, New York

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Peggion, E., Foffani, M.T., Mammi, S. (1991). Structure-Function Relationship of Gastrin Hormones: A Rational Approach to Drug Design. In: Pandit, U.K., Alderweireldt, F.C. (eds) Bioorganic Chemistry in Healthcare and Technology. NATO ASI Series, vol 207. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1354-0_10

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  • DOI: https://doi.org/10.1007/978-1-4684-1354-0_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1356-4

  • Online ISBN: 978-1-4684-1354-0

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