Abstract
The gastrins are a family of gastro-intestinal peptide hormones performing a wide range of biological functions in the digestive process. The sequences of the most common forms of gastrins are the following:
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pGlu-Leu-Gly-Pro-Gln-Gly-His-Pro-Ser-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly- Pro-Trp-Leu-(Glu)5-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (big gastrin);
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pGlu-Gly-Pro-Trp-Leu-(Glu)5-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (little gastrin);
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H-Trp-Leu-(Glu)5-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (minigastrin).
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References
J. S. Morley, H. J. Tracy, and R. A. Gregory, Structure-function relationships in the active C-terminal tetrapeptide sequence of gastrin, Nature 207:1356 (1965).
E. Peggion, E. Jager, S. Knof, L. Moroder, and E. Wiinsch, Conformational aspects of gastrin-related peptides: a circular dichroism study, Biopolymers 20:633 (1981).
E. Peggion, M. T. Foffani, E. Wiinsch, L. Moroder, G. Borin, M. Goodman, and S. Mammi, Conformational properties of gastrin fragments of increasing chain length, Biopolvmers 24:647 (1985).
C. C. Wu, A. Hachimori, and J. T. Yang, Lipid-induced ordered conformation of some peptide hormones and bioactive oligopeptides: predominance of helix over β form. Biochemistry 21:4556 (1982)
S. Mammi, N. J. Mammi, M. T. Foffani, E. Peggion, L. Moroder, and E. Wiinsch, Conformation of human little gastrin and minigastrin analogs in surfactant solution, Biopolvmers 26:S1 (1987).
E. Abillon, P. Pham Van Chuong, and P. Fromageot, Conformational calculations on gastrin C-terminal tetrapeptide, Int. J. Peptide Protein Res. 17:480 (1981).
P. Y. Chou, and G. D. Fasman, Empirical prediction of protein conformation, Ann. Rev. Biochem 47:251 (1978).
S. Mammi, N. J. Mammi, and E. Peggion, Conformational studies of human des-Trp1, Nle12-minigastrin in water-trifluoroethanol mixtures by 1H NMR and circular dichroism, Biochemistry 27:1374 (1988).
K. Amonraksa, M. Simonetti, S. DaRin-Fioretto, S. Mammi, and E. Peggion, Synthesis and 1H NMR studies of α-deuterated analogues of des- Trp1, Nle12-human minigastrin, Biopolvmers 30:000 (1990) (in press).
S. Mammi, M. T. Foffani, E. Peggion, J. C. Galleyrand, J. P. Bali, M. Simonetti, W. Goring, L. Moroder, and E. Wiinsch, Conformational and biological properties of the Ala10 analogue of human des-Trp1, Nle12- minigastrin, Biochemistry 28:7182 (1989).
A. A. Ribeiro, R. Saltman, and M. Goodman, Conformational analyses of polyoxyethylene-bound homo-oligo-L-glutamates in a helix-supporting environment, trifluoroethanol, Biopolvmers 24:2469 (1985).
E. Wiinsch, R. Scharf, E. Peggion, M. T. Foffani, and J. P. Bali, Conformational properties of gastrin peptides: synthesis, biological activity, and preliminary CD characterization of the (Asp)5 analog of des- Trp1, Leu12-minigastrin, Biopolvmers 25:229 (1986).
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© 1991 Plenum Press, New York
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Peggion, E., Foffani, M.T., Mammi, S. (1991). Structure-Function Relationship of Gastrin Hormones: A Rational Approach to Drug Design. In: Pandit, U.K., Alderweireldt, F.C. (eds) Bioorganic Chemistry in Healthcare and Technology. NATO ASI Series, vol 207. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1354-0_10
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DOI: https://doi.org/10.1007/978-1-4684-1354-0_10
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