Abstract
The first report of surface-attached heparin was by Gott and coworkers in 1965 (8). In this work, heparin was attached through formation of a complex with a quaternary ammonium salt that was adsorbed on graphite. The discovery of the thromboresistant properties of heparinized surfaces was inadvertent: the original intent of the work was to evaluate graphite. The graphite surface was treated with a quaternary ammonium salt to sterilize it, and the surface was rinsed in heparin as a simple precautionary measure. Gott et al. showed that the marked thromboresistance of the graphite- benzalkonium-heparin (GBH) surface was due to the presence of heparin This held promise of enabling the use of foreign sufaces in contact with blood without systemic anticoagulation. However, in practice, the GBH coating could not be applied to flexible materials; thus, its use was limited.
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Falb, R.D., Leininger, R.I., Grode, G., Crowley, J. (1975). Surface-Bonded Heparin. In: Bradshaw, R.A., Wessler, S. (eds) Heparin. Advances in Experimental Medicine and Biology, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0946-8_32
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DOI: https://doi.org/10.1007/978-1-4684-0946-8_32
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