Abstract
Heparin is a naturally occurring polyanion found in many tissues. The biologic properties of heparin that have been most extensively investigated are its anticoagulant activity and its interaction with lipoprotein lipase (for representative reviews, see Freeman (4) and Ehrlich and Stivala (3)). Various reports suggest that heparin and possibly other acid mucopolysaccharides also play a role in the regulation of cell growth (14). We have investigated the effect of heparin on the translation of natural mammalian messenger RNA (mRNA) in mammalian cell-free systems (6, 19–21), and we present here some of our findings concerning heparin’s action as an inhibitor of the translation of exogenous rabbit globin mRNA in a Krebs ascites cell- free system.
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© 1975 Plenum Press, New York
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Goldstein, J., Waldman, A.A., Marx, G. (1975). Heparin as an Inhibitor of Mammalian Protein Synthesis. In: Bradshaw, R.A., Wessler, S. (eds) Heparin. Advances in Experimental Medicine and Biology, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0946-8_26
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DOI: https://doi.org/10.1007/978-1-4684-0946-8_26
Publisher Name: Springer, Boston, MA
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