Abstract
Cultures of dissociated neurons (Barinaga, 1990; Bulloch & Syed, 1992) constitute a promising method for characterizing the auto-organization properties of populations of neurons under controlled physico-chemical conditions. Neurons can survive for weeks in culture, where they reorganize into two-dimensional networks. Especially in the case of populations obtained from vertebrate embryos, these networks cannot be regarded as faithful reproductions of in vivo situations, but rather as new rudimentary neurobiological systems whose activity can change over time spontaneously or as a consequence of chemical/physical stimuli (Gross, Rhoades, Jordan, 1992). Quite a recent technique, appropriate for recording the electrical activity of networks of cultured neurons, lies in using substrate transducers, i.e., arrays of planar microtransducers forming the adhesion surface for the reorganizing networks.
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Bove, M., Grattarola, M., Martinoia, S. (1996). Coupling of Networks of Neurons to Substrate Planar Microtransducers. In: Torre, V., Conti, F. (eds) Neurobiology. NATO ASI Series, vol 289. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5899-6_20
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