Abstract
Organisms continuously monitor their environment, employing highly specialized systems such as vision, hearing and olfaction to extract pertinent information from an array of physical stimuli. These physical sensations are then transformed into transduction events.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Shepherd GM (1994) Discrimination of molecular signals by the olfactory receptor neuron. Neuron 13:771–790
Dahl A (1988) The effect of cytochrome P450-dependent metabolism and other enzyme activites on olfaction. In: Margolis TV (ed) Molecular Neurobioloy of the Olfactory System. Plenum Press, New York, pp 51–70
Hibert MF, Trump-Kallmeyer S, Bruinvels A, Hoflack J (1991) Three-dimensional models of neurotransmitter G-binding protein coupled receptors. Molecular Pharmacology 40:8–15
Kurahashi T, Yau K-W (1993) Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells. Nature 363:71–74
Firestein S, Shepherd GM (1995) Interaction of anionic and cationic currents leads to a voltage dependence in the odor response of olfactory receptor neurons. Journal of Neurophysiology 73:562–567
Kaissling K-E (1986) Chemo-electrical transduction in insect olfactory receptors. Annual Review of Neuroscience 9:121–145
Lancet D (1986) Vertebrate olfactory reception. Annual Review of Neuroscience 9:329–355
Kaissling K-E, Thorson J (1980) Insect olfactory sensilla:structural, chemical and electrical aspects of the functional organization. In: Satelle DB, Hall ML, Hildebrand JG (ed) Receptors for neurotransmitters, hormones and pheromones in insects. Elsevier/North-Holland, Amsterdam, pp 261–282
Vogt RG, Riddiford LM (1981) Pheromone binding and inactivation by moth antennae. Nature 293:161–163
Bignetti E, Cavaggioni A, Pelosi P, Persaud KC, Sorbi RT, Tirindelli R (1985) Purification and characterization of an odorant-binding protein from cow nasal tissue. European Journal of Biochemistry 149:227–231
Pevners J, Sklar P, Snyder SH (1985) Characterization of an odorant-binding protein from bovine and rat nasal mucosa. Proc. Natl Acad. Sci. 83:4942–4946
Lee KH, Wells RG, Reed RR (1987) Isolation of an olfactory cDNA: similarity to retinal-binding protein suggest a role in olfaction. Science 1053–1056
Vogt RG, Rybczynski R, Lerner MR (1990) The biochemistry of odorant reception and transduction. In: Schild D (ed) Chemosensory Information Processing. Springer Verlag, Berlin, pp 33–76
Buck LB, Axel R (1991) A novel multigene family may encode odorant receptors: A molecular basis for odor recognition. Cell 65:175–187
Ressler KJ, Sullivan SL, Buck LB (1994) A molecular dissection of spatial patterning in the olfactory system. Current Opinion in Neurobiology 4:588–596
Ngai J, Dowling MM, Buck LB, Axel R, Chess A (1993) The family of genes encoding odorant receptors in the channel catfish. Cell 72:657–666
Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Grootegoed A, Vassart G (1992) Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature 355:453–455
Pace U, Hanski E, Salomon Y, Lancet D (1985) Odorant-sensitive adenylate cyclase may mediate olfactory reception. Nature 316:255–258
Sklar PB, Anholt RRH, Snyder SH (1986) The odorant sensitive adenylate cyclase of olfactory receptor cells: Differential stimulation by distinct classes of odorants. Journal of Biological Chemistry 261:15538–15543
Breer H, Boekhoff I, Tareilus E (1990) Rapid kinetics of second messenger formation in olfactory transduction. Nature 345:65–68
Restrepo D, Boekhoff I, Breer H (1993) Rapid kinetic measurements of second messenger formation in olfactory cilia from channel catfish. The American Journal of Physiology 264:c906–c911
Jones DT, Reed RR (1989) Golf: An olfactory neuron specific-G protein involved in odorant signal transduction. Science 244:790–795
Krupinski J, Coussen F, Bakalyar HA, Tang W-J, Feinstein PG, Orth K, Slaughter C, Reed RR, Gilman AG (1989) Adenylyl cyclase amino acid sequence: Possible channel-or transporter-like structure. Science 244:1558–1564
Bakalyar HA, Reed RR (1990) Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science 250:1403–1406
Nakamura T, Gold GH (1987) A cyclic-nucleotide gated conductance in olfactory receptor cilia. Nature 325:442–444
Dhallan RS, Yau K-W, Schrader KA, Reed RR (1990) Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature 347:184–187
Ludwig J, Margalit T, Eismann E, Lancet D, Kaupp UB (1990) Primary structure of cAMP-gated channel from bovine olfactory epithelium. FEBS Letters 270:24–29
Goulding E, Ngai J, Kramer R, Colicos S, Axel R, Siegelbaum S, Chess A (1992) Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons. Neuron 8:45–58
Zufall F, Firestein S, Shepherd GM ( 1991 ) Analysis of single cyclic nucleotide-gated channels in olfactory receptor cells. Journal of Neuroscience 11:3573–3580
Yau K-W (1994) Cyclic nucleotide-gated channels: An expanding new family of ion channels. Proc. Natl. Acad.Sci. 91:3481–3483
Kaupp UB, Altenhofen W (1992) Cyclic nucleotide-gated channels of vertebrate photoreceptor cells and olfactory epithelium. In: Corey DP, Roper SD (ed) Sensory Transduction. Rockefeller Univ Press, New York, pp 133–150
Firestein S, Zufall F (1994) The cyclic nucleotide-gated channel of olfactory receptor neurons. Seminars in Cell Biology 5:39–46
Firestein S (1992) Physiology of transduction in the single olfactory sensory neuron. In: Corey DP, Roper SD (ed) Sensory Transduction. Rockefeller Univ Press, New York, pp 61–71
Firestein S, Picco C, Menini A (1993) The relation between stimulus and response in olfactory receptor cells of the tiger salamander. Journal of Physiology 468:1–10
Menini A, Picco, C, and Firestein, S (1995) Quantal-like current fluctuations induced by odorants in olfactory receptor cells. Nature 373:435–437
Kurahashi T (1989) Activation by odorants of cation-selective conductance in the olfactory receptor cell isolated from the newt. Journal of Physiology 419:177–192
Zufall F, Shepherd GM, Firestein S (1991) Inhibition of the olfactory cyclic nucleotide-gated ion channel by intracellular calcium. Proc Roy Soc Ser B 246:225–230
Kramer RH, Siegelbaum SA (1992) Intracellular Ca2+ regulates the sensitivity of cyclic nucleotide-gated channels in olfactory receptor neurons. Neuron 9:897–906
Liu M, Chen T-Y, Basheer A, Li J, Yau K-W (1994) Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel. Science 266:1348–1354
Borisy FF, Ronnett GV, Cunningham AM, Julifs D, Beavo J, Snyder SH (1992) Calcium/calmodulin-ac-tivated phosphodiesterase expressed in olfactory receptor neurons. Journal of Neuroscience 12:915–923
Dohlman HG, Torner J, Caron MG, Lefkowitz RJ (1991) Model systems for the study of seven-trans-membrane-segment receptors. Annual Review of Biochemistry 60:653–688
Dawson TM, Arriza JL, Jaworsky DE, Borisy FF, Attramadal H, Lefkowitz RJ, Ronnett GV (1993) B-adrenergic receptor kinase-2 and B-arrestin-2 as mediators of odorant-induced desensitization. Science 259:825–829
Breer H, Boekhoff I, Krieger J, Raming K, Strotmann J, Tareilus E (1992) Molecular mechanisms of olfactory signal transduction. In: Corey DP, Roper SD (ed) Sensory Transduction. Rockefeller University Press, New York, pp 93–108
Boekhoff I, Breer H (1990) Differential stimulation of second messengers pathways by distinct classes of odorants. Neurochemistry International 17:553–557
Boekhoff I, Tareilus E, Strotmann J, Breer H (1990) Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants. EMBO Journal 2453–2458
Kalinoski DL, Aldinger SB, Boyle AG, Huque T, Marecek JF, Prestwich GD, Restrepo D (1992) Characterization of a novel inositol 1,4,5-triphosphate receptor in isolated olfactory cilia. Biochemical Journal 281:449–456
Fadool DA, Ache BW (1992) Plasma membrane inositol 1,4,5-trisphosphate-activated channels mediate signal transduction in lobster olfactory receptor neurons. Neuron 9:907–918
Okada Y, Teeter JH, Restrepo D (1994) Inositol 1,4,5-trisphosphate-gated conductance in isolated rat olfactory neurons. Journal of Neurophysiology. 71:595–602
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Broillet, MC., Firestein, S. (1996). Olfactory Sensory Transduction. In: Torre, V., Conti, F. (eds) Neurobiology. NATO ASI Series, vol 289. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5899-6_12
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5899-6_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7706-1
Online ISBN: 978-1-4615-5899-6
eBook Packages: Springer Book Archive