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Childhood Leukemia: Present Problems and Future Prospects pp 3–22Cite as

Etiological Mechanisms in Childhood Acute Lymphoblastic Leukemia

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Part of the book series: Developments in Oncology ((DION,volume 65))

Abstract

Childhood acute lymphoblastic leukemia (ALL) is a biologically diverse malignancy. The major subsets correspond to B or T precursor cells, although some ALL may originate in lympho—myeloid stem cells. Multiple molecular alterations contribute to the pathogenesis of ALT., including some that are subset specific. In those cases (~5%) with a Philadelphia chromosome, the genetic basis of karyotypic alteration and the resultant activated ABL kinase have been determined and offer new strategies for molecular diagnosis and monitoring. Although these changes at the DNA level are likely to be functionally relevant to the underlying mechanisms of leukemogenesis, the etiology of childhood ALL remains an enigma. A hypothesis is proposed that takes into account geographic and time trend variations in incidence rates, unusual properties of lymphocyte precursors, and promoting effects of immune responses in infancy.

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Authors and Affiliations

  1. Leukaemia Research Fund Centre, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves, Li Chong Chan, Anthony M. Ford, Susan M. Pegram & Leanne M. Wiedemann

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  1. Melvyn F. Greaves
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  2. Li Chong Chan
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  3. Anthony M. Ford
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  4. Susan M. Pegram
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  5. Leanne M. Wiedemann
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Editors and Affiliations

  1. National Children’s Hospital, 3-35-31 Taishido, Setagaya-ku, Tokyo 154, Japan

    Noboru Kobayashi

  2. The National Children’s Hospital Medical Research Center, Tokyo, Japan

    Tai Akera

  3. Department of Virology, The National Children’s Medical Research Center, 3-35-31 Taishido, Setagaya-ku, Tokyo 154, Japan

    Shuki Mizutani

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© 1991 Springer Science+Business Media New York

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Greaves, M.F., Chan, L.C., Ford, A.M., Pegram, S.M., Wiedemann, L.M. (1991). Etiological Mechanisms in Childhood Acute Lymphoblastic Leukemia. In: Kobayashi, N., Akera, T., Mizutani, S. (eds) Childhood Leukemia: Present Problems and Future Prospects. Developments in Oncology, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3898-1_1

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  • DOI: https://doi.org/10.1007/978-1-4615-3898-1_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6739-0

  • Online ISBN: 978-1-4615-3898-1

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