Abstract
The structures of human lactoferrin in its iron free1 (apoLf) and iron saturated2 (Fe2Lf) forms have been determined crystallographically at high resolution (2.0 and 2.2 Å respectively). The root-mean-square errors in positions of the individual atoms are of the order of 0.2–0.3 Å, which means that it is possible to make meaningful comparisons between the two structures with a view to understanding how iron binding and release are accomplished.
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Anderson, B.F., Norris, G.E., Rumball, S.V., Thomas, D.H., Baker, E.N. (1994). A Comparison of the Three-Dimensional Structures of Human Lactoferrin in its Iron Free and Iron Saturated Forms. In: Hutchens, T.W., Rumball, S.V., Lönnerdal, B. (eds) Lactoferrin. Advances in, Experimental Medicine and Biology, vol 357. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2548-6_22
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DOI: https://doi.org/10.1007/978-1-4615-2548-6_22
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