Abstract
Laser-induced interstitial thermal therapy (LITT) of brain tumors is a minimally invasive surgical technique for the treatment of solid brain tumors [17, 21]. The concept of MRI monitoring and control of LITT was introduced and experimentally proven by Jolesz (a-d) as early as 1988. The technique was tested in patients by Ascher in 1991 [1] and since has been reported in literatures by multiple investigators [2, 6, 10, 13, 16]. The results of these clinical trials demonstrate that MRI-guided LITT is a feasible and effective tool for primary and metastatic malignant brain tumor treatment. In the original study of Bettag et al., the laser fibers were inserted under CT guidance and treatment was monitored by T1-weighted MRI [2], or T1 images, while others used the water proton frequency shift-based phase mapping method [14, 27] to delimitate the extent of ablation. The usefulness of MRI-guided LITT was highlighted when Kath et al. reported imaging tumor with contrast agent (Gd-DTPA) and performed phase-sensitive temperature-sensitive sequences for MRI thermometry [12] ensuring the maximum coverage of thermal ablation over the lesions. Later, Kettenbach et al. reported the MRI-guided LITT performed completely under guidance by 0.5-tesla (T) MRI where special MRI made for intervention was also used to locate the tumor, positioning the fiber and monitoring the extent of ablation [13]. Similar works to perform MRI-guided LITT in a same 0.5 T scanner, but in more subjects, were published with 24 cases (7 low-grade gliomas, 11 anaplastic gliomas, 6 glioblastomas) [15] and 16 recurrent glioma subjects [25]. More recently, Carpentier et al. reported on treatment of brain metastasis using MRI-guided LITT in a closed bore 1.5 T scanner. The positioning of the cooled diffuser tip laser probe was done outside the scanner using a Leksell stereotactic head frame. After the patient was brought into the closed bore scanner, the ablation was monitored by temperature-sensitive MRI [3].
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References
Ascher PW, Justich E, Schrottner O. Interstitial thermotherapy of central brain tumors with the Nd:YAG laser under real-time monitoring by MRI. J Clin Laser Med Surg. 1991;9:79–83.
Bettag M, Ulrich F, Schober R, Furst G, Langen KJ, Sabel M, Kiwit JC. Stereotactic laser therapy in cerebral gliomas. Acta Neurochir Suppl (Wien). 1991;52:81–3.
Carpentier A, McNichols RJ, Stafford RJ, Itzcovitz J, Guichard JP, Reizine D, Delaloge S, Vicaut E, Payen D, Gowda A, George B. Real-time magnetic resonance-guided laser thermal therapy for focal metastatic brain tumors. Neurosurgery. 2008;63:ONS21–8; discussion ONS28–9.
Damianou C, Ioannides K, Hadjisavvas V, Mylonas N, Couppis A, Iosif D. In vitro and in vivo brain ablation created by high-intensity focused ultrasound and monitored by MRI. IEEE Trans Ultrason Ferroelectr Freq Control. 2009;56:1189–98.
el-Ouahabi A, Guttmann CR, Hushek SG, Bleier AR, Dashner K, Dikkes P, Black PM, Jolesz FA. MRI guided interstitial laser therapy in a rat malignant glioma model. Lasers Surg Med. 1993;13:503–10.
Fan M, Ascher PW, Schrottner O, Ebner F, Germann RH, Kleinert R. Interstitial 1.06 Nd:YAG laser thermotherapy for brain tumors under real-time monitoring of MRI: experimental study and phase I clinical trial. J Clin Laser Med Surg. 1992;10:355–61.
Feyh J, Gutmann R, Leunig A, Jager L, Reiser M, Saxton RE, Castro DJ, Kastenbauer E. MRI-guided laser interstitial thermal therapy (LITT) of head and neck tumors: progress with a new method. J Clin Laser Med Surg. 1996;14:361–6.
Hata N, Piper S, Jolesz FA, Tempany CM, Black PM, Morikawa S, Iseki H, Hashizume M, Kikinis R. Application of open source image guided therapy software in MR-guided therapies. Med Image Comput Comput Assist Interv. 2007;10:491–8.
ITK: National Library of Medicine Insight Segmentation and Registration Toolkit, Insight Software Consortium; 1999.
Kahn T, Bettag M, Ulrich F, Schwarzmaier HJ, Schober R, Furst G, Modder U. MRI-guided laser-induced interstitial thermotherapy of cerebral neoplasms. J Comput Assist Tomogr. 1994;18:519–32.
Kahn T, Harth T, Bettag M, Schwabe B, Ulrich F, Schwarzmaier HJ, Modder U. Preliminary experience with the application of gadolinium-DTPA before MR imaging-guided laser-induced interstitial thermotherapy of brain tumors. J Magn Reson Imaging. 1997;7:226–9.
Kahn T, Harth T, Kiwit JC, Schwarzmaier HJ, Wald C, Modder U. In vivo MRI thermometry using a phase-sensitive sequence: preliminary experience during MRI-guided laser-induced interstitial thermotherapy of brain tumors. J Magn Reson Imaging. 1998;8:160–4.
Kettenbach J, Silverman SG, Hata N, Kuroda K, Saiviroonporn P, Zientara GP, Morrison PR, Hushek SG, Black PM, Kikinis R, Jolesz FA. Monitoring and visualization techniques for MR-guided laser ablations in an open MR system. J Magn Reson Imaging. 1998;8:933–43.
Kuroda K, Oshio K, Chung AH, Hynynen K, Jolesz FA. Temperature mapping using the water proton chemical shift: a chemical shift selective phase mapping method. Magn Reson Med. 1997;38:845–51.
Leonardi MA, Lumenta CB. Stereotactic guided laser-induced interstitial thermotherapy (SLITT) in gliomas with intraoperative morphologic monitoring in an open MR: clinical experience. Minim Invasive Neurosurg. 2002;45:201–7.
Leonardi MA, Lumenta CB, Gumprecht HK, von Einsiedel GH, Wilhelm T. Stereotactic guided laser-induced interstitial thermotherapy (SLITT) in gliomas with intraoperative morphologic monitoring in an open MR-unit. Minim Invasive Neurosurg. 2001;44:37–42.
Menovsky T, Beek JF, Roux FX, Bown SG. Interstitial laser thermotherapy: developments in the treatment of small deep-seated brain tumors. Surg Neurol. 1996;46:568–71; discussion 571–62.
Morikawa S, Inubushi T, Kurumi Y, Naka S, Sato K, Tani T, Yamamoto I, Fujimura M. MR-guided microwave thermocoagulation therapy of liver tumors: initial clinical experiences using a 0.5 T open MR system. J Magn Reson Imaging. 2002;16:576–83.
Morocz IA, Hynynen K, Gudbjartsson H, Peled S, Colucci V, Jolesz FA. Brain edema development after MRI-guided focused ultrasound treatment. J Magn Reson Imaging. 1998;8:136–42.
Nabavi A, Gering DT, Kacher DF, Talos IF, Wells WM, Kikinis R, Black PM, Jolesz FA. Surgical navigation in the open MRI. Acta Neurochir Suppl. 2003;85:121–5.
Sakai T, Fujishima I, Sugiyama K, Ryu H, Uemura K. Interstitial laserthermia in neurosurgery. J Clin Laser Med Surg. 1992;10:37–40.
Schenck JF, Jolesz FA, Roemer PB, Cline HE, Lorensen WE, Kikinis R, Silverman SG, Hardy CJ, Barber WD, Laskaris ET. Superconducting open-configuration MR imaging system for image-guided therapy. Radiology. 1995;195:805–14.
Schwabe B, Kahn T, Harth T, Ulrich F, Schwarzmaier HJ. Laser-induced thermal lesions in the human brain: short- and long-term appearance on MRI. J Comput Assist Tomogr. 1997;21:818–25.
Schwarzmaier HJ, Eickmeyer F, von Tempelhoff W, Fiedler VU, Niehoff H, Ulrich SD, Ulrich F. MR-guided laser irradiation of recurrent glioblastomas. J Magn Reson Imaging. 2005;22:799–803.
Schwarzmaier HJ, Eickmeyer F, von Tempelhoff W, Fiedler VU, Niehoff H, Ulrich SD, Yang Q, Ulrich F. MR-guided laser-induced interstitial thermotherapy of recurrent glioblastoma multiforme: preliminary results in 16 patients. Eur J Radiol. 2006;59:208–15.
Silverman SG, Sun MR, Tuncali K, Morrison PR, vanSonnenberg E, Shankar S, Zou KH, Warfield SK. Three-dimensional assessment of MRI-guided percutaneous cryotherapy of liver metastases. AJR Am J Roentgenol. 2004;183:707–12.
Stollberger R, Ascher PW, Huber D, Renhart W, Radner H, Ebner F. Temperature monitoring of interstitial thermal tissue coagulation using MR phase images. J Magn Reson Imaging. 1998;8:188–96.
VTK: Visualization Tool Kit, Kitware. www.vtk.org. Accessed 23 Jan 2013.
Wells 3rd WM, Viola P, Atsumi H, Nakajima S, Kikinis R. Multi-modal volume registration by maximization of mutual information. Med Image Anal. 1996;1:35–51.
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Hata, N., Morrison, P.R., Cselik, Z., Kikinis, R., Black, P.M., Jolesz, F.A. (2014). MRI-Guided and Controlled Laser-Induced Interstitial Thermal Therapy of Brain Tumors Using Integrated Navigation and Thermal Mapping. In: Jolesz, F. (eds) Intraoperative Imaging and Image-Guided Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7657-3_42
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