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A Cold Isn’t Going to Slow Me Down

Midazolam, goldenseal, CYP3A4, CYP3A5, CYP2D6

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A Case Approach to Perioperative Drug-Drug Interactions

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Abstract

This case discusses a pharmacokinetic interaction between midazolam and goldenseal. Midazolam is a cytochrome P450 3A4, 3A5, and 2D6 substrate and goldenseal is an inhibitor of these enzymes. Coadministration leads to prolonged sedative effects of midazolam.

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References

  1. Complementary Medicine, Goldenseal. University of Maryland Medical Center. http://www.umm.edu/altmed/articles/goldenseal-000252.htm. Accessed 20 Sept 2009.

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Author information

Authors and Affiliations

  1. Oregon Anesthesiology Group, Portland, OR, USA

    Leelee Thames

  2. Oregon Anesthesiology Group, Providence St. Vincent’s Hospital, Portland, OR, USA

    Jessica Miller

Authors
  1. Leelee Thames
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  2. Jessica Miller
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Corresponding author

Correspondence to Leelee Thames .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

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Thames, L., Miller, J. (2015). A Cold Isn’t Going to Slow Me Down. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_79

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_79

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

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