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Cancer Therapeutic Targets pp 1–9Cite as

Anti-B7-H4

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Abstract

B7-H4, also known as B7x or B7S1, is a new member of the B7 family of immune co-signaling molecules. Despite the wide distribution in mRNA levels, B7-H4 protein expression is generally absent in peripheral tissues but is increased on many cancer cells or tumor-associated immune cells. In addition, B7-H4 up-regulation has shown to be associated with diseases progression and/or outcome in some cancers. The unique expression of B7-H4 in the tumor microenvironment and its potential immune inhibitory functions on both innate and adaptive immune responses represents a novel target for the next-generation cancer diagnosis and immunotherapy.

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Author information

Authors and Affiliations

  1. Department of Immunobiology and Yale Cancer Center, Yale University School of Medicine, New Haven, CT, 06511, USA

    Jun Wang

  2. Cancer Immunology Program, Yale University School of Medicine, Yale Cancer Center, 131D, 10 Amistad Street, New Haven, CT, 06519, USA

    Lieping Chen

Authors
  1. Jun Wang
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  2. Lieping Chen
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Corresponding author

Correspondence to Lieping Chen .

Editor information

Editors and Affiliations

  1. Georgetown University Div. Hematology & Oncology, Washington, District of Columbia, USA

    John L. Marshall

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© 2013 Springer Science+Business Media New York

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Wang, J., Chen, L. (2013). Anti-B7-H4. In: Marshall, J. (eds) Cancer Therapeutic Targets. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6613-0_48-6

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  • DOI: https://doi.org/10.1007/978-1-4614-6613-0_48-6

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6613-0

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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