Abstract
Collagen is the most abundant protein of lung connective tissue and as such will influence normal lung function. Thus alteration in its structure, metabolism or distribution may impair lung function - in particular that related to gas exchange. In crypto-genic fibrosing alveolitis (also termed idiopathic pulmonary fibrosis) there is morphological evidence for excessive and disorded collagen deposition. For this reason, evidence has been sought to explain the disease on the basis of alterations in collagen biochemistry. In this paper, some aspects of collagen biochemistry as it relates to the lung will be discussed and the concept of whether or not pulmonary fibrosis is a disease of altered collagen metabolism examined.
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© 1982 Plenum Press, New York
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Laurent, G.J. (1982). Collagen in Normal Lung and During Pulmonary Fibrosis. In: Cumming, G., Bonsignore, G. (eds) Cellular Biology of the Lung. Ettore Majorana International Science Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3403-3_17
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DOI: https://doi.org/10.1007/978-1-4613-3403-3_17
Publisher Name: Springer, Boston, MA
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