Abstract
The use of porphyrin preparations in conjunction with visible light in Photodynamic Therapy (PDT) is dependent on two important properties exhibited by these compounds, i.e. their preferential uptake and localisation in malignant tissue and the fact that such porphyrins are very efficient photosensitisers. By direct absorption of light they are electronically excited to higher energy levels from which they can, by energy transfer processes, donate this energy to acceptor molecules giving porphyrin deactivation and elevation of acceptor to excited states possibly not attainable by direct absorption under these conditions.
Keywords
- Human Serum Albumin
- Cetyl Trimethyl Ammonium Bromide
- Photophysical Property
- Laser Flash Photolysis
- Monomeric Species
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Amand, R. and Bensasson, R.V., 1975, Determination of Triplet Quantum Yields by Laser Flash Absorption Spectroscopy, Chem. Phys. Lett., 34:44.
Andreoni, A., Cubeddu, R., De Silvestfi, S., Laporta, P., Jori, G. and Reddi, E., 1982, Hematoporphyrin Derivative: Experimental Evidence for Aggregated Species, Chem, Phys. Lett., 88:33.
Bonnett, R., Ridge, R. J., Scourides, P.A. and Berenbaum, M.C., 1981, On the Nature of Haematoporphyrin Derivative, J. Chem. Soc., Perkin I, 3135.
Brown, S.B., Shillcock, M. and Jones, P., 1976, Equilibrium and Kinetic Studies of the Aggregation of Porphyrins in Aqueous Solution, Biochem J., 153: 279.
Chauvet, J.P., Viovy, R., Santus, R. and Land, E.J., 1981, One-Electron Oxidation of Photosynthetic Pigments in Micelles. Bacteriochlorophyll a, Chlorophyll a, Chlorophyll b and Pheophytin a, J. Phys. Chem., 85:3449.
Craw, M., Redmond, R. and Truscott, T.G., 1984, Laser Flash Photolysis of Haematpporphyrins in some Homogeneous and Heterogeneous Environments, J. Chem. Soc., Faraday Trans. I, 80:2293.
Dahlman, A., Wile, A.G. Burns, R.G., Mason, G.R. Johnson, F.M. and Berns, M.W., 1983, Laser Photoradiation Therapy of Cancer, Cancer Res., 43: 430.
Dougherty, T.J., Potter, W.R. and Weishaupt, K.R., 1983, The Structure of the Active Component of Hematoporphyrin Derivative, in: “Porphyrins in Tumour Phototherapy”, A. Andreoni and R. Cubeddu, eds., Plenum Press, 23.
Jori, G., Beltramini, M., Reddi, E., Salvato, B., Pagnan, A., Ziron, L., Tomio, L. and Tsanov, T., 1984, Evidence for a Major Role of Plasma Lipo¬proteins as Hematoporphyrin Carriers in Vivo, Cancer Letters, 24: 291.
Kessel, D. and Chou, T.-H., 1983, Tumor-Localizing Components of the Porphyrin Preparation Hematoporphyrin Derivative, Cancer Res, 43: 1994.
Kessel, D., 1984, Hematoporphyrin and HPD: Photophysics, Photochemistry and Phototherapy, Photochem. Photobiol., 39:851.
Moan, J., Christensen, T. and Sommer, S., 1982, The Main Photosensitizing Components of Hematoporphyrin Derivative, Cancer Letters, 15: 161.
Moan, J. and Sommer, S., 1983, Uptake of the Components of Hematoporphyrin Derivative by Cells and Tumours, Cancer Letters, 21: 167.
Reddi, E., Ricchelli, F. and Jori, G., 1981, Interaction of Human Serum Albumin with Hematoporphyrin and its Zn2+ and Fe3+ Derivatives, Int. J. Peptide Protein Res., 18:402.
Reddi, E., Jori, G., Rodgers, M.A.J, and Spikes, J., 1983, Flash Photolysis Studies of Hemato- and Copro-Porphyrins in Homogeneous and Microheterogeneous Aqueous Dispersions, Photochem. Photobiol., 38:639.
Torinuki, W., Miura, T. and Seiji, M., 1980, Lysosome Destruction and Lipo-peroxide Formation Due to Active Oxygen Generated from Hematoporphyrin and U.V. Irradiation. Br. J. Dermatol., 102:17.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Redmond, R.W., Land, E.J., Truscott, T.G. (1985). Aggregation Effects on the Photophysical Properties of Porphyrins in Relation to Mechanisms Involved in Photodynamic Therapy. In: Kessel, D. (eds) Methods in Porphyrin Photosensitization. Advances in Experimental Medicine and Biology, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2165-1_28
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2165-1_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9276-0
Online ISBN: 978-1-4613-2165-1
eBook Packages: Springer Book Archive