Abstract
The molecular heterogeneity of human growth hormone (hGH) extracted from pituitary tissue has been extensively studied by Lewis et al, (1977, 1978, 1980) and Talamantes et al, (1981) who described most of the charge and size variants. These were considered as resulting from pre- and post-translational processing, affecting the final products originally coded by the GH-N gene. Indeed, the alternative splicing of the hGH pre-mRNA has been shown by Wallis (1980), elucidating the mechanism leading to the synthesis of the major 22K and 20K hGH pituitary forms, these proteins being then submitted to post-translational modifications.
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References
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Frankenne, F., Closset, J., Gomez, F., Pirens, G., Smal, J., Hennen, G. (1988). Monoclonal Antibodies for the Study of Human Growth Hormone Forms and Variants. In: Hubbard, R., Marks, V. (eds) Clinical Applications of Monoclonal Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1573-5_10
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DOI: https://doi.org/10.1007/978-1-4613-1573-5_10
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