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Radiodermatitis and Other Adverse Sequelae of Cutaneous Irradiation

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Physical Modalities in Dermatologic Therapy

Abstract

Radiodermatitis may be defined as any deleterious effect produced in the skin and its appendages by radiation which either has been administered in therapeutic applications or received as a consequence of accidental overexposure. The effects may range from an acute inflammatory reaction to a noninflamed chronic condition.

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References

  1. Abe T, Sugai T, Saito T: Radiation angiokeratoma following grenz irradiation. Arch Dermatol 100: 294, 1969

    Article  PubMed  CAS  Google Scholar 

  2. Albert RE, Omran AR: Follow-up study of patients treated by x ray for tinea capitis. Arch Environ Health 17: 899, 1968

    PubMed  CAS  Google Scholar 

  3. Albright EC, Allday RW: Thyroid carcinoma after radiation therapy for acne vulgaris. JAMA 199: 128, 1967

    Article  Google Scholar 

  4. Alden HS, Weens HS, Yoamans HD: Observations on radiation exposure in dermatologic x- ray therapy. Arch Dermatol 79: 159, 1959

    CAS  Google Scholar 

  5. Anderson LP, Anderson HE: Development of basal cell epithelioma as a consequence of radiodermatitis. Arch Dermatol 63: 586, 1951

    CAS  Google Scholar 

  6. Arena V: Ionizing Radiation and Life. St Louis, Mosby, 1971, pp 446–457

    Google Scholar 

  7. Arnold HL Jr: Erythema multiforme following high voltage roentgen therapy. Arch Dermatol Syph 60: 143, 1949

    Google Scholar 

  8. Beach SA, Dolphin GW: A study of the relationship between x-ray dose delivered to the thyroid of children and the subsequent development of malignant tumors. Phys Med Biol 6: 583, 1962

    Article  Google Scholar 

  9. Becher FO, et al: Adult thyroid cancer after head and neck irradiation in infancy and childhood. Ann Inter Med 83: 347, 1975

    Google Scholar 

  10. Black MM, Jones EW: Dermal cylindroma following x-ray epilation of the scalp. Br J Dermatol 85: 70, 1971

    Article  PubMed  CAS  Google Scholar 

  11. Braasck NK, Nickson MJ: A study of the hands of radiologists. Radiology 51: 719, 1949

    Google Scholar 

  12. Cannon B, Randolph JG, Murray JE: Malignant irradiation for benign conditions. N Engl J Med 260: 197, 1959

    Article  PubMed  CAS  Google Scholar 

  13. Carr C, et al: Protective agents modifying biological effects of radiation. Arch Environ Health 21: 88, 1970

    PubMed  CAS  Google Scholar 

  14. Carroll RG: The relationship of head and neck irradiation to the subsequent development of thyroid neoplasms. Semin Nucl Med 6: 411, 1976

    Article  PubMed  CAS  Google Scholar 

  15. Chung J, Song CW, Yamaguchi T, et al: Effects of anti-inflammatory compounds on irradiation induced radiodermatitis. Dermatologica 144: 97, 1972

    Article  PubMed  CAS  Google Scholar 

  16. Cipollaro AC, Crossland PM: X Rays and Ra-dium in the Treatment of Diseases of the Skin, 5th ed. Philadelphia, Lea & Febiger, 1967, pp 394–395

    Google Scholar 

  17. Cipollaro AC, Kallos A, Ruppe JPJ: Measurement of gonadal radiations during treatment for tinea capitis. NY State J Med 59: 30, 1959

    Google Scholar 

  18. DeGroot L, Paloyan E: Thyroid cancer and radiation. A Chicago endemic. JAMA 225: 487, 1973

    Article  PubMed  CAS  Google Scholar 

  19. Depenbusch FL: Chromosomal aberrations in man due to low levels of ionizing radiation. A pilot study. Milit Med 137: 436, 1972

    CAS  Google Scholar 

  20. deRay BM, Cabrini RL: Ultrastructural alterations in X-irradiated epidermis. J Invest Dermatol 60: 136, 1973

    Google Scholar 

  21. Ellenger F: Medical Radiation Biology. Spring-field, Ill, Thomas, 1957

    Google Scholar 

  22. Epstein E: Dermatologie radiotherapy 1973. Presented at Fifth Aspen Conference for Dermatologists. Dermatol News 6: 8, 1973

    Google Scholar 

  23. Epstein E: Radiodermatitis. Springfield, Ill, Thomas, 1962, p 75

    Google Scholar 

  24. Epstein S: Importance of overlapping for the occurrence of roentgen late injuries in surface therapy. Arch Dermatol Syph 168: 548, 1933

    Article  Google Scholar 

  25. Favus MJ, et al: Thyroid cancer occurring as a late consequence of head and neck irradiation. N Engl J Med 294: 1019, 1976

    Article  PubMed  CAS  Google Scholar 

  26. Foye WO: Radiation-protective agents in mammals. J Pharm Sci 58: 283, 1969

    Article  PubMed  CAS  Google Scholar 

  27. Goldschmidt HG: Dermatologie radiotherapy and thyroid cancer. Cutis 18: 551, 1976

    PubMed  CAS  Google Scholar 

  28. Greco FA, Brereton HD, Kent H, et al: Adriamycin and enhanced reaction in normal esophagus and skin. Ann Intern Med 85: 294, 1976

    PubMed  CAS  Google Scholar 

  29. Harley NH, Albert RE, Shore RE, et al: Follow-up study of patients treated by x-ray epilation for tinea capitis. Estimation of the dose to the thyroid and pituitary glands and other structures of the head and neck. Phys Med Biol 21: 631, 1976

    Article  PubMed  CAS  Google Scholar 

  30. Hesse O: Das Röntgenkarzinom. Fort sehr Geb Röntgenstrahlen 17: 82, 1911

    Google Scholar 

  31. Information for physicians on irradiation. Related thyroid cancer. CA 26: 150, 1976

    Google Scholar 

  32. Jolles B, Harrison RG: Enzymic processes and vascular changes in the skin radiation reaction. Br J Radiol 39: 12, 1966

    Article  PubMed  CAS  Google Scholar 

  33. Jolles B, Harrison RG: Radiation skin reactions and depletion and restoration of body immune response. Nature 198: 1216, 1963

    Article  Google Scholar 

  34. Jolles B, Harrison RG: Studies of the influence of wave lengths on biological effects. Time and dose differentials at “radiation action sites in the skin. ” Strahlentherapie 139: 716, 1970

    PubMed  CAS  Google Scholar 

  35. Jolles B, Harrison RG: Enzymic processes and vascular changes in the skin radiation reaction. Br J Radiol 39: 12, 1966

    Article  PubMed  CAS  Google Scholar 

  36. Katz F: Observation on grenz rays reactions. Dermatologica 118: 357, 1959

    Article  Google Scholar 

  37. Kirk J, Worthley BW: Superficial radiotherapy in acne vulgaris. Australas J Dermatol 12: 10, 1971

    Article  PubMed  CAS  Google Scholar 

  38. Klayman DL, Copeland ES: The design of anti-radiation agents. In Ariens EJ (ed): Drug Design, Vol 6. New York, Academic Press, 1975, pp 81–142

    Google Scholar 

  39. Kuban AK, Farah FS: Effects of irradiation on the skin. Acta Derm Venereol (Stockh) 49: 64, 1969

    Google Scholar 

  40. Ledoux-Corbusie M, Achten G: Elastosis in chronic radiodermatitis. Br J Dermatol 91: 287, 1974

    Article  Google Scholar 

  41. Lever, WF, Schaumberg-Lever G: Histopathology of the Skin, 5th ed. Philadelphia, Lippincott, 1975, pp 196–198

    Google Scholar 

  42. Lewis HM: Twenty years experience with grenz rays. Bull Assoc Mil Dermatol 21: 17, 1973

    CAS  Google Scholar 

  43. Lund HZ: How often does squamous cell carcinoma metastasize? Arch Dermatol 92: 635, 1965

    Article  PubMed  CAS  Google Scholar 

  44. Malkinson FD, Griem ML: Cysteamine protection of x-ray induced dysplasia in mouse hair. A summary. In Pillsbury DM, Livingood CS (eds): Proceedings of the XII International Congress of Dermatology. Amserdam, Excerpta Medica, 1962, pp 585–586

    Google Scholar 

  45. Martin H, Strong E, Spiro RH: Radiation-induced skin cancer of the head and neck. Cancer 25: 61, 1970

    Article  PubMed  CAS  Google Scholar 

  46. Merriam GR Jr, Focht EF: A clinical study of radiation cataracts and relationship to dose. Am J Roentgenol 77: 759, 1957

    Google Scholar 

  47. Modan B, et al: Radiation-induced head and neck tumours. Lancet 1: 277, 1974

    Article  PubMed  CAS  Google Scholar 

  48. Montgomery H: Pathologic histology of radiodermatitis. In Cipollare AC, Crossland PM: X Rays and Radium in the Treatment of Diseases of the Skin, 5th ed. Philadelphia, Lea and Febiger, 1967, pp 411–545

    Google Scholar 

  49. Montgomery H: Burns and radiodermatitis. In Montgomery H (ed): Dermatopathology, 2nd ed. New York, Hoeber, 1967, pp 232–248

    Google Scholar 

  50. Montgomery AH, Montgomery RM, Montgomery DC: The problem of plantar radiodermatitis. NY State J Med 49: 1664, 1949

    CAS  Google Scholar 

  51. National Academy of Sciences: The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: Advisory Committee on the Biological Effects of Ionizing Radiations. Washington, DC, USGPO, 1974

    Google Scholar 

  52. Park GT, Davis J: Radiation cancer of the skin. Radiology 84: 436, 1965

    Google Scholar 

  53. Pegum JS: Radiation-induced skin cancer. Br J Radiol 45: 613, 1972

    PubMed  CAS  Google Scholar 

  54. Petet VD, Chamness JT, Ackerman LU: Fibromatosis and fibrocarcoma following irradiation therapy. Cancer 7: 149, 1954

    Article  Google Scholar 

  55. Petratos MA, et al: Measurement of scattered radiation to body areas during radiotherapy of basal cell epitheliomas. Dermatol Int J Dermatol 8: 10, 1969

    Article  CAS  Google Scholar 

  56. Pillsbury DM, Shelley WB, Kligman AM: Dermatology. Philadelphia, Saunders, 1956, p 334

    Google Scholar 

  57. Rachmaninoff N, McDonald JR, Cook JC: Sarcoma-like tumors of the skin following irradiation. Am J Clin Pathol 36: 427, 1961

    PubMed  CAS  Google Scholar 

  58. Refetoff S, et al: Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood. N Engl J Med 292: 171, 1975

    Article  PubMed  CAS  Google Scholar 

  59. Rice DH, et al: Postirradiation malignant salivary gland tumor. Arch Otolaryngl 102: 699, 1976

    CAS  Google Scholar 

  60. Ridley CM: Basal cell cancer following x-ray epilation of the scalp. Br J Dermatol 74: 222, 1962

    Article  PubMed  CAS  Google Scholar 

  61. Rook A, Wilkinson DS, Ebling FJG: Textbook of Dermatology, 2nd ed. Oxford, Blackwell Scientific, 1972,p 471

    Google Scholar 

  62. Rowell NR: A follow-up study of superficial radiotherapy for benign dermatoses. Recommendations for the use of x rays in dermatology. Br J Dermatol 88: 583, 1973

    Article  PubMed  CAS  Google Scholar 

  63. Sagher F: Squamous cell carcinomas due to grenz rays. In Pillsbury DM, Livingood CS (eds): Proceedings of the XII International Congress of Dermatology. Amsterdam, Excerpta Medica, 1962, pp 638–639

    Google Scholar 

  64. Sarkany I, Fountain RB, Evans CD, et al: Multiple basal cell epitheliomata following radiotherapy of the spine. Br J Dermatol 80: 90, 1968

    Article  Google Scholar 

  65. Schneider AB, et al: Plasma thyroglobulin in detecting thyroid carcinoma after childhood, head and neck irradiation. Ann Intern Med 86: 29, 1977

    PubMed  CAS  Google Scholar 

  66. Shapiro EM, Knox JM, Freeman RG: Carcinogenic effects of prolonged exposure to grenz ray. J Invest Dermatol 37: 291, 1961

    PubMed  CAS  Google Scholar 

  67. Simon N: Breast cancer induced by radiation. JAMA 237: 789, 1977

    Article  PubMed  CAS  Google Scholar 

  68. Sulzberger MB, Baer RL, Borota A: Do roentgen ray treatments as given by skin specialists produce cancers or other sequelae? Arch Dermatol Syph 65: 639, 1952

    CAS  Google Scholar 

  69. Sweet RD: Acute accidental superficial x-ray burns. Br J Dermatol 74: 392, 1962

    Article  PubMed  CAS  Google Scholar 

  70. Traenkle HL: X-ray induced cancer in man. Nat Cancer Inst Monogr 10: 243, 1963

    Google Scholar 

  71. Traenkle HL, Mulay D: Further observations on late radiation necrosis following therapy of skin cancer. Arch Dermatol 81: 908, 1960

    PubMed  CAS  Google Scholar 

  72. Urbach F: Pathologic effects of ionizing radiation In Fitzpatrick TB, et al (eds): Dermatology in general medicine. New York, McGraw-Hill Book Co, 1971, p 1042

    Google Scholar 

  73. Wendeyer BW: Radiotherapy in its relation to dermatology. Br Med J 1: 945, 1954

    Article  Google Scholar 

  74. Witten VH: Physical methods of protection against ionizing radiation in dermatologic therapy and its importance in relation to gonadal radiation exposure. In Pillsbury DM, Livingood CS (eds): Proceedings of the XII International Congress of Dermatology, Vol 1. Amsterdam, Excerpta Medica, 1962, pp 593–596

    Google Scholar 

  75. Witten VH, Sulzberger MB, Stewart WD: Studies on the quantity of radiation reaching the gonadal areas during dermatologic x-ray therapy. Arch Dermatol 76: 683, 1957

    CAS  Google Scholar 

  76. Zschunke E, Behrbohm P: Uber die behandlung des röntgenschadens an der haut mit prednisone. Dermatol Wochenschr 152: 1417, 196

    Google Scholar 

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Rudolph, R.I., Goldschmidt, H. (1978). Radiodermatitis and Other Adverse Sequelae of Cutaneous Irradiation. In: Goldschmidt, H. (eds) Physical Modalities in Dermatologic Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6259-6_5

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  • DOI: https://doi.org/10.1007/978-1-4612-6259-6_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6261-9

  • Online ISBN: 978-1-4612-6259-6

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