Abstract
Tryptamine concentrations in the rodent brain range from 16 fmol/mg protein (cerebellum) to 160 fmol/mg protein (striatum); concentrations which have lead to its designation as a trace amine (Philips et al., 1974; Philips et al., 1980; Juorio and Durden, 1984) . However, despite its low levels, this amine has a rapid turnover as evidenced by 6- to 12-fold increases in regional tryptamine levels after inhibition of monoamine oxidase (Philips et al., 1980; Juorio and Durden, 1984). A clear functional role for these dynamic pools of tryptamine has not been defined but the recent descriptions of a unique tryptamine receptor in the rat brain have suggested a potential neurotransmitter or neuromodulator role.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Altar, C.A., Walter, R.J., Neve, K. A. and Marshall, J.F. (1984) Computer-assisted video analysis of [3H]spiropiridol binding autoradiographs. J. Neurosci. Meth. 10, 173–188.
Altar, C.A., Wasley, A.M. and Martin, L.L. (1985) Autoradiographic-localization and pharmacology of unique [3H]tryptamine binding sites in rat brain. Neurosci. (in press)
Bliss, C.I. and James, A.T. (1966) Fitting the rectangular hyperbola. Biometrics 22, 573–602.
Cascio, C. S. and Kellar, K. J. (1983) Characterization of 3H-tryptamine binding sites in brain. Eur. J. Pharmacol. 95, 31–39.
Clineschmidt, B. V. and Lotti, V. J. (1974) Indoleamine antagonists: relative potencies as as inhibitors of tryptamine and 5-hydroxytrypt-amine-evoked responses. Brit. J. Pharmacol. 50, 311–313.
Cox, B., Lee, T. F. and Martin, D. (1981) Different hypothalamic receptors mediate 5-HT and tryptamine-induced core temperature changes in the rat. Brit. J. Pharmac. 72, 477–482.
Creese, I. and Silbey, D.R. (1981) Receptor adaptations to centrally acting drugs. Ann. Rev. Pharmacol. 21, 357–391.
Hicks, P. E. and Langer, S. Z. (1983) Antagonism by tetrahydro-B-carboline of the vasoconstrictor responses to tryptamine in rat tail arteries. Eur. J. Pharmacol. 96, 145–149.
Jones, R. S. G. (1982) A comparison of the responses of cortical neurones to iontophoretically applied tryptamine and 5-hydroxytryptamine in the rat. Neuropharmacology 21, 209–214.
Kellar, K. J. and Cascio, C. S. (1982) [3H]-Tryptamine: High affinity binding sites in rat brain. Eur. J. Pharm. 78, 475–478.
Luscombe, G., Jenner, P. and Marsden, C. D. (1982) Tryptamine-induced myoclonus in guinea-pigs pretreated with a monoamine oxidase inhibitor indicates pre-and post synaptic actions of tryptamine upon central indoleamine systems. Neuropharmacology 21, 1257–1265.
Martin, W. R. and Eades, C. G. (1970) The action of tryptamine on the dog spinal cord and its relationship to the agonist actions of LSD-like psychotogens. Psychopharmacology 57, 242–257.
Martin, W. R. and Eades, C. G. (1972) Cross tolerance to tryptamine in the LSD tolerant dog. Psychopharmacology 27, 93–98.
Martin, L. L., Roland, D. M., Neale, R. F. and Wood, P. L. (1984) H-Tryptamine binding in rat brain: Effects of phenylalkylamine derivatives. Pharmacologist 26, 135.
Martin, L. L. and Sanders-Bush, E. (1982) Comparison of the pharmacological characteristics of 5HT1 and 5HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release.Naunyn-Schmiedeberg’s Arch. Pharmacol. 321, 165–170.
Penny, J.B., Pan, H.S., Young, A.B., Frey, K.A. and Dauth, G.W. (1981) Quantitative autoradiography of [3H]muscimol binding in rat brain. Science 214, 1036–1038.
Phillips, S.R. and Boulton, A.A. (1979) The effect of monoamine oxidase inhibitors on some arylalkylamines in rat striatum. J. Neurochem. 33, 159–167.
Quock, R. M. and Weick, B. G. (1978) Tryptamine-induced drug effects insensitive to serotonergic antagonists: Evidence of specific tryptaminergic receptor stimulation? J. Pharm. Pharmac. 30, 280–283.
Rodbard, D. and Lewald, J.E. (1970) Computer analysis of radioligand assay and radioimmunoassay data. Acta Endocrinol. 147, 79–103.
Rommelspacher, H. and Bruning, G. (1984) Formation and function of tetrahydro-B-carbolines with special reference to their action on [3H]-tryptamine binding sites. In Progress in Tryptophan and Serotonin Research, Schlossberger, H. G., Kochen, W., Linzen, B. and Steinhart, H. (eds.), Walter de Gruyter, Berlin.
Stollak, J. S. and Furchgott, R.F. (1983) Use of selective antagonists for determining the types of receptors mediating the actions of 5-hydroxytryptamine and tryptamine in the isolated aorta. J. Pharmacol. Exp. Ther. 224, 215–221.
Winter, J. C. and Gessner, P. K. (1968) Phenoxybenzamine-antagonism of tryptamines, their indene isosteres and 5-hydroxytryptamine in the rat stomach fundus preparation. J. Pharmacol. Exp. Ther. 162, 286–293.
Wood, P. L., Pilapil, C., LaFaille, F., Nair, N. P. V. and Glennon, R. A. (1984) Unique [3H]tryptamine binding sites in rat brain: distribution and pharmacology. Arch. Int. Pharm. Ther. 268, 194–201.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 The Humana Press Inc.
About this chapter
Cite this chapter
Wood, P.L., Martin, L.L., Altar, C.A. (1985). [3H]Tryptamine Receptors in Rat Brain. In: Boulton, A.A., Maitre, L., Bieck, P.R., Riederer, P. (eds) Neuropsychopharmacology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5010-4_9
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5010-4_9
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9397-2
Online ISBN: 978-1-4612-5010-4
eBook Packages: Springer Book Archive