Skip to main content

The Trace Amines: Recent Overview and Future Pointers

  • Chapter

Abstract

At the 1st International Conference on the Trace Amines held in Edmonton, Canada in 1983, [Proceedings of which have been published Boulton et al. (1984)], not only was the new work up to the end of 1982 described but in addition, the general properties of the trace amines and their identification and quantitative analysis was reviewed. This 2nd meeting held in Tübingen, West Germany covers work completed since then. Clearly everything could not be included and so the organizers have chosen to concentrate on the neuro-and psycho-pharmacology of the trace amines and some bioclinical findings. Not all the trace amines could be included, for example, histamine, the polyamines, aliphatic amines and the classical biogenic amines when present in ‘trace’ concentrations, were ommitted as was the burgeoning role of the trace amines in invertebrate systems; rather, as in 1983, it was the arylalkylamines on which we focussed.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Boulton A.A., Baker G.B., Dewhurst W.G. and Sandler M. (eds.) (1984) Neurobiology of the Trace Amines. Humana Press, Clifton, New Jersey.

    Google Scholar 

  • Boulton A.A. and Dyck L.E. (1974) Biosynthesis and excretion of meta-and para-tyramine in the rat. Life Sci. 14, 2497–2506.

    Article  PubMed  CAS  Google Scholar 

  • Boulton A.A., Dyck L.E. and Durden D.A. (1974) Hydroxyla-tion of β-phenylethyl ami ne in the rat. Life Sci. 15, 1673–1683.

    Article  PubMed  CAS  Google Scholar 

  • Boulton A.A. and Juorio A.V. (1983) Cerebral decarboxylation of meta-and para-tyrosine. Experi entia 39, 130–134.

    CAS  Google Scholar 

  • Brüning G. and Rommelspacher H. (1984) High affinity [3H]tryptamine binding sites in various organs of the rat. Life Sci. 34, 1441–1446.

    Article  PubMed  Google Scholar 

  • Cascio C.S. and Kellar K.J. (1982) Tetrahydro-β-carbo-lines: affinities for tryptamine and serotonergic binding sites. Neuropharmacology 21, 1219–1221.

    Article  PubMed  CAS  Google Scholar 

  • Cascio C.S. and Kellar K.J. (1983) Characterisation of [3H]Tryptamine binding sites in brain. Eur. J. Pharmacol. 95, 31–39.

    Article  PubMed  CAS  Google Scholar 

  • Danielson T.J., Boulton A.A. and Robertson H.A. (1977) meta-Octopamine, para-octopamine and phenylethanolami ne in rat brain: a sensitive specific assay and the effect of some drugs. J. Neurochem. 29, 1131–1135.

    Article  PubMed  CAS  Google Scholar 

  • Davis B.A. and Boulton A.A. (1981a) Longitudinal urinary excretion of some ‘trace’ acids in a human male. J. Chromatog.: Biomed. Appln. 222, 161–169.

    Article  CAS  Google Scholar 

  • Davis B.A. and Boulton A.A. (1981b) Excretion of meta-hydroxymandelic acid in human urine. J. Chromatog.: Biomed Appln. 222, 271–275.

    Article  CAS  Google Scholar 

  • Davis B.A., Durden D.A. and Boulton A.A, (1985) Simultaneous analysis of 12 biogenic amine metabolites in plasma, cerebrospinal fluid and urine by capillary column gas chromatography-high resolution mass spectrometry with selected ion monitoring. J. Chromatog.: Biomed. Appln. (in press).

    Google Scholar 

  • Davis B.A., Yu P.H., Carlson K., O’Sullivan K. and Boulton A.A. (1982) Plasma levels of phenylacetic acid, m-and p-hydroxyphenylacetic acid and platelet MAO activity in schizophrenic and other patients. Psychiat. Res. 6, 97–105.

    Article  CAS  Google Scholar 

  • Domino E.F., Mathews B.N. and Tait S.K. (1979) Urinary neurotransmitter metabolites in drug-free schizophrenic patients measured by gas chromatography selected position ion monitoring. Biomed. Mass Spec. 6, 331–334.

    Article  CAS  Google Scholar 

  • Dourish C.T., Dewar K.M., Dyck L.E. and Boulton A.A. (1983b) Potentiation of the behavioural effects of the antidepressant phenelzine by deuterium substitution. Psychopharmacol. 81, 122–125.

    Article  CAS  Google Scholar 

  • Dourish C.T., Greensfiaw A.J. and Boulton A.A. (1983a) Deuterium substitution enhances the effects of phenyl-ethyl amine on spontaneous motor activity in the rat. Pharmacol. Biochem. Behav. 19, 471–475.

    Article  PubMed  CAS  Google Scholar 

  • Durden D.A. (1985) High resolution and rnetastable mass spectrometry of trace amines and metabolites. In, NEUROMETHODS, Vol 2. Amines and Their Metabolites (A.A. Boulton, G.B. Baker and J.M. Baker, eds.), Humana Press, Clifton, New Jersey (in press).

    Google Scholar 

  • Durden D.A. and Boulton A.A. (1982) Mass spectrometric analysis of some neurotransmitters and their precursors and metabolites. In, Handbook of Neurochemistry (A. Lathja, ed.), Plenum Press, New York, pp. 397–428.

    Google Scholar 

  • Durden D.A. and Philips S.R. (1980) Kinetic measurements of the turnover rates of phenyl ethyl amine and tryptamine in vivo in the rat brain. J. Neurochem. 34, 1725–1732.

    Article  PubMed  CAS  Google Scholar 

  • Dyck L.E. (1984) Neuronal transport of trace amines: an overview. In, Neurobiology of the Trace Amines (A.A. Boulton, G.B. Baker, W.G. Dewhurst and M. Sandler, eds.), Humana Press, Clifton, New Jersey, pp. 185–204.

    Google Scholar 

  • Dyck L.E., Boulton A.A. and Jones R.S.G. (1980) A comparison of the effects of methylphenidate and amphetamine on the simultaneous release of radiolabeled dopamine and m-and p-tyramine from rat striatal slices. Eur. J. Pharmacol. 68, 33–40.

    Article  PubMed  CAS  Google Scholar 

  • Dyck L.E., Durden D.A., Yu P.H., Davis B.A. and Boulton A.A. (1983) Potentiation of the biochemical effects of β-phenylhydrazine by deuterium substitution. Biochem. Pharmacol. 32, 1519–1522.

    Article  PubMed  CAS  Google Scholar 

  • Dyck L.E., Yang C.R. and Boulton A.A. (1983) The biosynthesis of p-tyramine, m-tyramine and β-phenylethylamine by rat striatal slices. J. Neurosci. Res. 10, 211–220.

    Article  PubMed  CAS  Google Scholar 

  • Foster A.B. (1984) Deuterium isotope effects in studies of drug metabolism. TIPS 5, 524–527.

    CAS  Google Scholar 

  • Harrison W.M., Cooper T.B., Quitkin F.M., Libowitz W.R., Mrath P.J., Stewart J.W. and Klein D.F. (1983) Tyramine sulfate excretion test in depressive illness. Psychopharm. Bull. 19, 503–504.

    Google Scholar 

  • Harrison W.M., Cooper T.B., Stewart J.W., Quitkin F.M., Mrath P.J., Liebowitz M.R., Rabkin J.R., Mankowitz J.S. and Klein D.F. (1984) The tyramine challenge test as a marker for melancholia. Arch. Gen. Psychiat. 41, 581–685.

    Google Scholar 

  • Ibrahim K.E., Couch M.W., Williams C.M., Fregly M.J. and Midgley J.M. (1985) m-Octopamine: normal occurrence with p-octopamine in mammalian sympathetic nerves. J. Neurochem. 44, 1862–1867.

    Article  PubMed  CAS  Google Scholar 

  • Jones R.S.G. (1982) Tryptamine: a neuromodulator or neurotransmitter in mammalian brain? Progress in Neurobiology 19, 117–139.

    Article  PubMed  CAS  Google Scholar 

  • Jones R.S.G. (1983) Trace biogenc amines: a possible functional role in the CNS. TIPS 4, 426–429.

    CAS  Google Scholar 

  • Jones R.S.G. (1984) Electrophysiological studies of the possible role of trace amines in synaptic function. In, Neurobiology of the Trace Amines (A.A. Boulton, G.B. Baker, W.G. Dewhurst and M. Sandler, eds.), Humana Press, Clifton, New Jersey, pp. 205–223.

    Google Scholar 

  • Juorio A.V. (1979a) Drug-induced changes in the formation, storage and metabolism of tyramine in the mouse. Brit. J. Pharmacol. 66, 377–384.

    CAS  Google Scholar 

  • Juorio A.V. (1979b) Effect of stress and L-dopa administration on mouse striatal tyramine and homovanillic acid levels. Brain Res. 179, 186–189.

    Article  PubMed  CAS  Google Scholar 

  • Juorio A.V. (1983) The effect of some decarboxylase inhibitors on mouse striatal tyramines. Neuropharmacology 22, 71–73.

    Article  PubMed  CAS  Google Scholar 

  • Juorio A.V. and Boulton A.A. (1982) The effect of some precursor amino acids and enzyme inhibitors on the mouse striatal concentration of tyramines and homovanillic acid. J. Neurochem. 39, 859–863.

    Article  PubMed  CAS  Google Scholar 

  • Kellar K.J. and Cascio C.S. (1982) [2H]Tryptamine: high affinity binding sites in rat brain. Eur. J. Pharmacol. 78, 475–478.

    Article  PubMed  CAS  Google Scholar 

  • Midgley J.M., Couch M.W., Crowley J.R. and Williams C.M. (1979) Identification and quantitative determination of o-and m-hydroxymandelic acid in human urine. Biomed. Mass Spec. 6, 485–490.

    Article  CAS  Google Scholar 

  • Palkovits M. (1985) Microdissection of individual brain nuclei and areas. In, NEUROMETHODS, Vol 1. General Techniques (in press).

    Google Scholar 

  • Philips S.R., Davis B.A., Durden D.A. and Boulton A.A. (1975) Identification and distribution of meta-tyramine in the rat. Can. J. Biochem. 53, 65–69.

    Article  PubMed  CAS  Google Scholar 

  • Richards J.C. and Spenser I.D. (1983) 2H NMR Spectroscopy as a probe of the stereochemistry of enzymic reactions at prochiral centres. Tetrahedron 39, 3549–3568.

    Article  CAS  Google Scholar 

  • Sabelli H.C., Fawcett J., Gusovsky F., Javaid J., Edwards J. and Jeffriess (1983) Urinary phenyl acetate: a diagnostic test for depression. Science 220, 1187–1188.

    Article  PubMed  CAS  Google Scholar 

  • Sandler M., Ruthven C.R.J., Goodwin B.L., Reynolds G.P., Rao V.A.R. and Coppen A. (1979) Deficient production of tyramine and dopamine in cases of depression. Nature 278, 357–358.

    Article  PubMed  CAS  Google Scholar 

  • Wu P.H. and Boulton A.A. (1975) Metabolism, distribution and disappearance of injected β-phenylethylamine in the rat. Can. J. Biochem. 52, 374–381.

    Google Scholar 

  • Yu P.H., Bailey B.A., Durien D.A. and Boulton A.A. (1985) Stereospecific deuterium substitution at the a-carbon position of dopamine and its effects on oxidative deamin-ation catalyzed by MAO-A and MAO-B from different tissues. Biochem. Pharmacol, (in press).

    Google Scholar 

  • Yu P.H., Barclay S., Davis B.A. and Boulton A.A. (1981) Deuterium isotope effects on the enzymatic oxidative deamination of trace amines. Biochem. Pharmacol. 30, 3089–3094.

    Article  PubMed  CAS  Google Scholar 

  • Yu P.H., Bowen R.C., Davis B.A. and Boulton A.A. (1983) Platelet MAO activity and trace acid levels in plasma of agoraphobic patients. Acta Psychiat. Scand. 67, 188–194.

    Article  PubMed  CAS  Google Scholar 

  • Yu P.H., Kazakoff C.W., Davis B.A. and Boulton A.A. (1982) Deuterium iosotope effects on the enzymatic oxidation of dopamine and serotonin. Biochem. Pharmacol. 31, 3697–3698.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 The Humana Press Inc.

About this chapter

Cite this chapter

Boulton, A.A. (1985). The Trace Amines: Recent Overview and Future Pointers. In: Boulton, A.A., Maitre, L., Bieck, P.R., Riederer, P. (eds) Neuropsychopharmacology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5010-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-5010-4_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9397-2

  • Online ISBN: 978-1-4612-5010-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics