Abstract
There is extensive experimental and epidemiologic evidence that suggests a relationship among diet, cancer, and heart disease. Recently nutrition has received added attention as an important factor in causation and prevention of cancer and coronary heart disease in humans.1Cancer and coronary heart disease are the two biggest killers in the industrialized world. Mechanisms are not worked out that determine the atherogenic or carcinogenic effects of nutrients. A wide variety of nutrients are implicated in development of various tumors and cardiovascular disorders. Both cancer and coronary heart disease are caused by the interaction of multiple factors, which include predetermined genetic susceptibility, environmental agents, occupation, and life styles, with emphasis on cigarette smoking, eating, and drinking patterns. It is estimated that 30–60% of cancer is attributed to life style habits or dietary indiscretions.2
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References
Doll R: Prospects for the prevention of cancer. Clin Radiol 34:609–623, 1983.
Newell GR: The provocative role of diet in carcinogenesis. Consultant 24(1): 116, 1984.
Doll R, Peto R: Mortality in relation to smoking: 20 years observations on male British doctors. Br Med J 2:1525–1536, 1976.
Assembly of Life Sciences, National Research Council: Executive Summary of the Report of the Committee on Diet, Nutrition and Cancer. Cancer Res 43:3018–3023, 1983.
Hirayama T: Diet and cancer. Nutr Cancer 1:67–81, 1979.
Sugimura T, Nagao M, Kawachi T, et al: Mutagen-carcinogen in food, with special reference to highly mutagenic pyrolytic products in broiled foods. In Hiatt HH et al. (eds): Origins of Human Cancer. Cold Spring Harbor, NY, 1977, pp 1561–1577.
Walker ARP: Colon cancer and diet, with special reference to intakes of fat and fiber. Am J Clin Nutr 29:1417, 1976.
Reddy BS, Wersburger JH, Wynder EL: Effects of high risk and low risk diets for colon carcinogenesis on fecal microflora and steroids in man. J Nutr 105:878, 1975.
Hirayama T: Epidemiology of breast cancer with special reference to the role of diet. Prev Med 7:173, 1978.
Armstrong B, Doll R: Environmental factors and cancer incidence and mortality in different countries with special reference to «dietary practices. Int J Cancer 15:617, 1975.
A co-operative trial in the primary prevention of ischemic heart disease using Clofibrate: Report from the Committee of Principal Investigators. Br Heart J 40:1069, 1978.
Reddy BS: Diet and excretion of bile acids. Cancer Res 41:3766, 1981.
Hill MJ, Drasar BS, Williams REO, et al: Fecal bile acids and Clostridia in patients with cancer of the large bowel. Lancet 1:535, 1975.
Reddy BS, Wynder L: Metabolic epidemiology of colon cancer: Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer 39:2533, 1977.
Reddy BS, Watanabek, Wersburger JH, et al: Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res 37:3238, 1977.
Keys A: Seven countries, a multivariate analysis of death and coronary heart disease. Cambridge, Harvard University Press, 1980.
Pooling Project Research Group: Relationship of blood pressure, serum cholesterol, smoking habit, relative weight, and ECG abnormalities to incidence of major coronary events: Final report of the pooling project. J Chron Dis 31:201–306, 1978.
Feldman EB: Familial hypercholesterolemia— Predecessor of coronary heart disease. Res Staff Phy 6:70, 1978.
Steinberg D: Research related to underlying mechanisms in atherosclerosis. Circulation 60:7, 1979.
DeWood MA, Spores J, Notske R, et al: Preva-lence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 303:897–902, 1980.
Rentrop KP, Blanke H, Karsch KR, et al: Acute myocardial infarciton: Intracoronary application of nitroglycerin and streptokinase. Clin Cardiol 2:354–363, 1979.
Anderson JL, Marshall HW, Bray BE, et al: A randomized trial of intracoronary streptokinase in the treatment of acute myocardial infarction. N Engl J Med 308:1312–1318, 1983.
Levy RI: Cholesterol, lipoproteins, apoproteins, and heart disease. Present status and future prospects. Clin Chem 27:653, 1981.
Krauss RM: Regulation of high density lipoprotein levels. Med Clin North Am 66:403, 1982.
Gordon T: The Framingham Diet Study. Diet and the regulation of serum cholesterol. U.S. Department of Health, Education and Welfare, 1970.
Multiple Risk Factor Intervention Trial Research Group: Multiple risk factor intervention trial. JAMA 248:1465–1477, 1982.
National Diet Heart Study Final Report, National Diet Heart Study Research Group 37 (Suppl 1): 1–419, 1968.
Kark JD, Smith AH, Haines CG: The relationship of serum cholesterol to the incidence of cancer in Evans County, Georgia. J Chron Dis 33:311–322, 1980.
Beaglehole R, Foulkes MA, Prior IA, et al: Cholesterol and mortality in New Zealand Maoris. Br Med J 1:285–287, 1980.
National Institutes of Health: Cholesterol and noncardio vascular mortality. JAMA 244:25, 1980.
Sidney S, Farquhar JW: Cholesterol, cancer and public health policy. Am J Med 75:494, 1983.
Williams RR, Sorlie PD, Feinlieb M, et al: Cancer incidence by levels of cholesterol. JAMA 245:247, 1981.
Dyer AR, Stamler J, Paul O, et al: Serum cholesterol and risk of death from cancer and other causes in three Chicago epidemiological studies. J Chron Dis 34:249–260, 1981.
Dabrowski MP, Peel WE, Thomson AE: Plasma membrane cholesterol regulates human lymphocyte cytotoxic function. Eur J Immunol 10:821–827, 1980.
Kannel WB, Gordon T (eds): The Framingham Diet Study: Diet and the regulation of serum cholesterol. U.S. Department of Health, Education and Welfare, 1970.
Peterson B, Trell E, Sternby NH: Low cholesterol level as a risk factor for non-coronary death in middle-aged men. JAMA 245:2056, 1981.
The Lipid Research Clinics Coronary Primary Prevention Trial Results. Reduction in incidence of coronary heart disease. JAMA 251:351, 1984.
Vitale JJ, Ross RN: Critique of NIH report on lipid research. Consultant 25(7): 141–150, 1985.
Nutrition and Your Health: Dietary Guidelines for Americans. Departments of Agriculture and Health, Education and Welfare, 1980.
Conner WE: The acceleration of thrombus formation by certain fatty acids. J Clin Invest 41:1199, 1962.
Keys A, Grande I, Anderson JT: Fiber and pectin in the diet and serum cholesterol concentration in man. Proc Soc Exp Biol Med 106:555, 1961.
Burkitt DP, Walker ARP, Painter NS: Dietary fiber and disease. JAMA 229:1068, 1974.
Durrington PN, Manning AP, Bolton CH, et al: Effect of pectin, guar gum and wheat fiber on serum cholesterol. Lancet 1:1116, 1975.
Peto R, Doll R, Buckley JP, et al: Can dietary beta-carotene materially reduce human cancer rates? Nature 290:201–208, 1981.
Committee on Diet, Nutrition and Cancer: Diet, Nutrition and Cancer. Washington DC, National Academy Press, 1982.
Select Committee on Nutrition and Human Needs, U.S. Senate. Dietary Goals for the United States, 2nd ed., U.S. Government Printing Office, 1977.
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Kapoor, A.S. (1986). Role of Nutrition in Cancer and Heart Disease. In: Kapoor, A.S. (eds) Cancer and the Heart. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4898-9_26
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DOI: https://doi.org/10.1007/978-1-4612-4898-9_26
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