Abstract
There are very good reasons to believe that lung hyperinflation plays a crucial role in the deterioration of inspiratory muscle function. In fact, it is very likely that chronic respiratory failure (hypoxemia and hypercapnia) in chronic obstructive pulmonary disease (COPD patients may develop because of the mechanical disadvantages of the inspiratory muscles rather than (or in addition to) disruption of the ventilation perfusion ratio. The mechanisms of ventilatory failure in COPD are complex and through the years have captured the attention of many physiologists and clinicians who have contributed in-depth analyses of some of the possible mechanisms leading to chronic failure. We review next some of the evidence available in the literature of the last 25 years, and we will show how the interpretations of chronic respiratory failure mechanisms evolved.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Robin E., O’Neill R.: The fighter versus the nonfighter. Arch. Environm. Health 1963; 7:125–129
Whitelaw W., Derenne J.P., Milic-Emili J.: Occlusion pressure as a measure of respiratory center output in conscious man. Resp. Physiol. 1975; 23:181–189
Sorli J., Grassino A., Lorange G., Milic-Emili J.: Control of breathing in patients with COPD. Clin. Sci. Mol. Med. 1978; 54:295–304
Grassino A., Macklem P.T.: Respiratory muscle fatigue and ventilatory failure. Ann. Rev. Med. 1984; 35:626–647
Bellemare F., Grassino A.: Effect of pressure and timing of contraction on human diaphragmatic fatigue. J. Appl. Physiol. 1982; 53:1190–1195
Bellemare F., Grassino A.: Evaluation of human diaphragmatic fatigue. J. Appl. Physiol. 1982; 53:1196–1206
Bellemare F., Grassino A.: Force reserve of the diaphragm in COPD patients. J. Appl. Physiol. 1982; 55:8–15
Skatrud J.B., Dempsey J. A., Bhansali P., Irvin C: Determinants of chronic carbon dioxide retention and its correction in humans. J. Clin. Invest. 1980; 65:813–821
Pardy R.L., Roussos C: Endurance of hyperventilation in COPD. Chest 1983; 83:744–750
Sadoul N., Bazzy R., Akabas S., G.G. Haddad: Ventilatory responses to fatiguing and non-fatiguing resistive loads in awake sheep. J. Appl. Physiol. 1985; 59:969–978
Laporta D., Grassino A.: Assessment of Pdi in humans. J. Appl. Physiol. 1985; 58:1469–1476
Martin J., Moreno R.H., Pare P., Pardy R.L.: Measurement of inspiratory muscle performance with incremental loads. Am. Rev. Respir. Dis. 1987; 135:919–923
Begin P., Grassino A.: Prevalence of CO2 retention in COPD patients related to inspiratory muscle and lung dysfunction. Am. Rev. Respir. Dis. 1986; 133: A191
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Italia
About this paper
Cite this paper
Grassino, A., Begin, P. (1991). The Effect of Lung Hyperinflation on Inspiratory Muscle Function. In: Grassino, A., Rampulla, C., Ambrosino, N., Fracchia, C. (eds) Chronic Pulmonary Hyperinflation. Current Topics in Rehabilitation. Springer, London. https://doi.org/10.1007/978-1-4471-3782-5_12
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3782-5_12
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3784-9
Online ISBN: 978-1-4471-3782-5
eBook Packages: Springer Book Archive