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An Overview on Animal Models of ALL

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New Agents for the Treatment of Acute Lymphoblastic Leukemia

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Abstract

Further advances in the understanding of the molecular processes essential for the development, spread, and survival of cancer cells are leading to the identification and validation of new targets for anti-cancer therapy. It is imperative that the pace of screening and drug development technology can keep up, so as to enable the transfer of interesting hypotheses into useful drugs in patients. One of the challenges facing leukemia research is the development and validation of clinically relevant animal models of disease, both to improve our understanding of the mechanisms involved, and to provide reliable efficacy testing for new therapeutic agents. In recent years, a great deal of progress has been made in this field. This chapter hopes to summarise these studies, and looks forward in the future modelling of acute lymphoblastic leukemia.

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  1. Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute, 4th floor, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK

    Josef H. Vormoor

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  1. Michael A. Batey
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Correspondence to Josef H. Vormoor .

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  1. Christie Hospital, Dept. Paediatric & Adolescent Oncology, University of Manchester, Manchester, M20 4BX, United Kingdom

    Vaskar Saha

  2. , School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom

    Pamela Kearns

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Batey, M.A., Vormoor, J.H. (2011). An Overview on Animal Models of ALL. In: Saha, V., Kearns, P. (eds) New Agents for the Treatment of Acute Lymphoblastic Leukemia. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8459-3_6

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