Abstract
This chapter is focused on the flow of gas into and out of the mammalian lung. We study the airway tree shown in Fig. 5.2:2. In the airway, the mixing of gases is given particular attention. In alveoli, the exchange of O2 and CO2 between alveolar gas and red blood cells is discussed. The effectiveness of this exchange depends on the matching of ventilation and circulation.
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References
Bates, C.V., Macklem, P.T., and Christie, R.V. (1971). Respiratory Function in Disease. Saunders, Philadelphia.
Bohn, D.J., Miyasaka, K., Marchak, B.E., Thompson, W.K., Froese, A.B., and Bryan, A.C. (1980). Ventilation by high frequency oscillation. J. Appl. Physiol.: Respir. Environ. Exer. Physiol. 48: 710–716.
Briscoe, W.A., Forster, R.E., and Comroe, J.H. (1954). Alveolar ventilation at very low tidal volumes. J. Applied Physiol. 7: 27–30.
Brown, F.T. (1962). The transient response of fluid lines. J. Basic Engineering 84: 547–553.
Chang, H.K. (1984). Mechanics of gas transport during ventilation by high frequency oscillation. J. Appl. Physiol. 56: 553–563.
Chang, H.K., Cheng, R.T., and Farhi, L.E. (1973). A model study of gas diffusion in alveolar sacs. Respiration Phys. 18: 386–397.
Chang, H.K., Isabey, D., Shykoff, B.E., and Harf, A. (1984). Gas mixing during high frequency oscillation. In Biomechanics in China, Japan and USA. (Y.C. Fung, J.J. Wang, and E. Fukada, eds.), Science Press, Peaking, pp. 264–280.
Chang, H.K., Tai, R.C., and Farhi, L.E. (1975). Some simplifications of ternary diffusion in the lung. Respiration Phys. 23: 109–120.
Chatwin, P.C. (1975). On the longitudinal dispersion of passive contaminant in oscillatory flows in tubes. J. Fluid Mech. 71: 513–527.
Cumming, G., Henderson, R., Horsfield, K., and Singhal, S.S. (1968). The functional morphology of the pulmonary circulation. In The Pulmonary Circulation and Interstitial Space ( A. Fishman and H. Hecht, eds.), University Chicago Press, Chicago, pp. 327–338.
Cumming, G. and Semple, S.J. (1973). Disorders of the Respiratory System. Blackwell Sci. Pub., London.
Dubois, A.B. (1964). Resistance to breathing. In Handbook of Physiology, Sec. 3 Respiration, Vol.1 ( W.O. Fenn and H. Rahn, eds.). Amer. Physiol. Soc. Washington, D.C. 1964, pp. 451–462.
Fenn, W.O. and Rahn, H. (eds.) (1964). Handbook of Physiology Sec. 3 Respiration, Vols. 1 2., 1696 pp. American Physiological Society, Washington, D.C.
Fishman, A., Macklem, P., and Mead, J. (eds.) (1986). Handbook of Physiology, Sec. 3. Respiration. Amer. Physiol. Soc. Washington, D.C.
Fry, D.L. and Hyatt, R.E. (1960). Pulmonary mechanics. A unified analysis of the relationship between pressure, volume and gasflow in the lungs of normal and diseased human subjects. Amer. J. Med. 29: 672–689.
Fung, Y.C. (1977). A First Course in Continuum Mechanics, 2nd edn. Prentice-Hall, Englewood Cliffs, N.J.
Fung, Y.C. (1983). Biodynamics: Circulation. Springer-Verlag, New York.
Henderson, Y., Chillingworth, F.P., and Whitney, J.L. (1915). The respiratory dead space. Amer. J. Physiol. 38: 1–19.
Hirschfelder, J.O., Curtis, C.F., and Bird, R.B. (1954). Molecular Theory of Gases and Liquids. Wiley, New York.
Hyatt, R.E., Schilder, D.P., and Fry, D.L. (1958). Relationship between maximum expiratory flow and degree of lung inflation. J. Appl. Physiol. 13: 331–336.
Jaeger, M.J. and Matthys, H. (1968 69). The patten of flow in the upper human airways. Respiration Phys. 6: 113–127.
Krogh, M. (1914 15). The diffusion of gases through the lungs of man. J. Physiol (London) 49: 271–300.
Lee, J.S. (1984). The mixing and axial transport of smoke in oscillatory tube flows. Annals of Biomed. Eng. 12: 371–383.
Lee, J.S. (1984). A transient analysis of gas transport in oscillatory tube flows. In Biomechanics in China, Japan, and USA (Y.C. Fung, J.J. Wang, and E. Fukada, eds.). Science Press, Peking, pp. 254–263.
Otis, A.B., McKerrow, C.B., Bartlett, R.A., Mead, J., Mcllroy, M.B., Selverstone, N.J., and Radford, E.P., Jr. (1956). Mechanical factors in distribution of pulmonary ventilation. J. Appl. Physiol. 8: 427–443.
Pedley, T.J., Schroter, R.C., and Sudlow, M.F. (1971). Flow and pressure drop in systems of repeatedly branching tubes. J. Fluid Mech. 46: 365–383.
Pedley, T.J., Schroter, R.C., and Sudlow, M.F. (1977). Gas flow and mixing in the airways. In Bioengineering Aspects of the Lung ( J.B. West, ed.), Marcel Dekker, New York, pp. 163–265.
Prasad, S.N. and Herrmann, G. (1969). The usefulness of adjoint systems in solving nonconserva-tive stability problems. Int. J. Solids and Struct. 5: 727–735.
Prasad, S.N. and Herrmann, G. (1972). Adjoint variational methods in nonconservative stability problems. Int. J. Solids and Struct. 8: 29–40.
Pride, N.B., Permutt, S., Riley, R.L., and Bromberger-Barnea, B. (1967). Determinants of maximal expiratory flow from the lungs. J. Appl. Physiol. 23: 646–662.
Roughton, F.J.W. and Forster, R.E. (1957). Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung. J. Appl. Physiol. 11: 291–302.
Scherer, P.W. and Haselton, F.R. (1982). Convective exchange in oscillatory flow through bronchial-tree models. J. Appl. Physiol.: Respir. Environ. Exer. Physiol. 53 (4): 1023–1033.
Schmid-Schoenbein, G. and Fung, Y.C. (1978). Forced perturbation of respiratory system. (A) The traditional model. Annals of Biomed. Eng. 6: 194–211. (B) A continuum mechanics analysis. ibid, 6: 367–398.
Seguchi, Y., Fung, Y.C., and Maki, H. (1984). Computer simulation of dynamics of fluid-gas-tissue systems with a discretization procedure and its application to respiration dynamics. In Biomechanics in China, Japan, and USA ( Y.C. Fung, E. Fukada, J.J. Wang, eds.). Chinese Science Press, Beijing, pp. 224–239.
Seguchi, Y., Fung, Y.C. and Ishida, T. (1986). Respiratory Dynamics-Compter simulation. In Frontiers in Biomechanics ( G.W. Schmid-Schönbein, S.L.Y. Woo, B.M. Zweifach, eds). Springer Verlag, New York, pp. 377–391.
Slutsky, A.A., Drazen, J.M., Ingram, R.H., Jr., Kamm, R.D., Shapiro, A.H., Fredberg, J.J., Loring, S.H., and Lehr, J. (1980). Effective pulmonary ventilation with small-volume oscillations at high frequency. Science 209: 609–611.
Slutsky, A.S., Kamm, R.D., Rossing, T.H., Loring, S.H., Lehr, J., Shapiro, A.H., and Ingram, R.H., Jr. (1981). Effects of frequency, tidal volume, and lung volume on CO2 elimination in dogs by high frequency (2–30 Hz) low tidal volume ventilation. Clin. Invest. 68: 1475–1484.
Stewart, G.N. (1893). Researches on the circulation time in organs and on the influences which affect it. J. Physiol. (London)15:1–30. II. Time of the lesser circulation, 15:31–72. III. Thyroid gland, 15: 73–89. The output of the heart, 22: (1900) 159–173.
Streeter, V.L. and Wylie, E.B. (1967). Hydraulic Transients. McGraw-Hill, New York.
Taylor, G.I. (1953). Dispersion of soluble matter in solvent flowing slowly through a tube. Proc. Roy. Soc. (London), Series A, 219: 186–203.
Taylor, G.I. (1954). The dispersion of matter in turbulent flow through a pipe. Proc. Roy. Soc. (London), Series A., 223: 446–468.
Tisi, G.M. (1980). Pulmonary Physiology in Clinical Medicine. Williams and Wilkins, Baltimore, Maryland.
Van der Pol, B. and Bremmer, H. (1950). Operational Calculus, Cambridge University Press, London New York, pp. 305–307.
Wagner, P.P. and West, J.B. (1972). Effects of diffusion impairment on 02 and CO2 time courses in pulmonary capillaries. J. Applied Physiol. 33: 62–71.
Weibel, E.R. (1963). Morphometry of the Human Lung. Academic Press, New York.
West, J.B. (1974). Respiratory Physiology-The Essentials. Williams and Wilkins, Baltimore. West, J.B. (1982). Pulmonary Pathophysiology-the essentials. 2nd ed. Williams and Wilkins,Baltimore.
West, J.B. and Wagner, P.D. (1977). Pulmonary gas exchange. In Bioengineering Aspects of the Lung ( J.B. West, ed.), Marcel Dekker, New York, pp. 361–457.
Whittle, P. (1971). Otpimization Under Constraints: Theory and Applications of Nonlinear Programming. Wiley-Interscience, London, New York.
Winter, D.C. and Nerem, R.M. (1984). Turbulence in pulsatile flows. Annals of Biomed. Eng. 12: 357–369.
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Fung, Y.C. (1990). Respiratory Gas Flow. In: Biomechanics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6856-2_7
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DOI: https://doi.org/10.1007/978-1-4419-6856-2_7
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