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Therapeutic Applications of Cell Microencapsulation pp 68–79Cite as

Artificial cell microencapsulated stem cells in regenerative medicine, tissue engineering and cell therapy

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 670))

Abstract

Adult stem cells, especially isolated from bone marrow, have been extensively investigated in recent years. Studies focus on their multiple plasticity of transdifferentiating into various cell lineages and on their potential in cellular therapy in regenerative medicine. In many cases, there is the need for tissue engineering manipulation. Among the different approaches of stem cells tissue engineering, microencapsulation can immobilize stem cells to provide a favorable microenvironment for stem cells survival and functioning. Furthermore, microencapsulated stem cells are immunoisolated after transplantation. We show that one intraperitoneal injection of microencapsulated bone marrow stem cells can prolong the survival of liver failure rat models with 90% of the liver removed surgically. In addition to transdifferentiation, bone marrow stem cells can act as feeder cells. For example, when coencapsulated with hepatocytes, stem cells can increase the viability and function of the hepatocytes in vitro and in vivo.

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Authors and Affiliations

  1. Artificial Cells and Organs Research Centre, Departments of Physiology, Medicine and Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, H3G 1Y6

    Zun Chang Liu & Thomas Ming Swi Chang

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  1. Zun Chang Liu
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  2. Thomas Ming Swi Chang
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  1. Laboratory of Pharmacy and Pharmaceutical Technology, University of the Basque Country, Vitoria-Gasteiz, Spain

    José Luis Pedraz PHD  & Gorka Orive PhD  & 

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Liu, Z.C., Swi Chang, T.M. (2010). Artificial cell microencapsulated stem cells in regenerative medicine, tissue engineering and cell therapy. In: Pedraz, J.L., Orive, G. (eds) Therapeutic Applications of Cell Microencapsulation. Advances in Experimental Medicine and Biology, vol 670. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5786-3_7

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