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Radiometals (non-Tc, non-Re) and Bifunctional Labeling Chemistry

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Handbook of Nuclear Chemistry

Abstract

Radiometals are of increased current interest because of the growing use of targeted radiotherapy for tumors and the development of generators that produce positron-emitting radiometals. In addition, biomedical cyclotrons allow the cheap production of some relevant radiometals. The design of the corresponding radiopharmaceuticals includes the synthesis of bifunctional chelators, which carry a functional unit for the immobilization of the radiometal and a functional group for the covalent attachment to a vector molecule. Radiometals of interest for therapeutic applications are some lanthanides, 67Cu, and 90Y. For diagnostic applications 61Cu, 62Cu, 64Cu, 89Zr, and 68Ga are currently used and corresponding radiopharmaceuticals are being designed. In this chapter, some properties and the synthesis of bifunctional chelators including metal ion selectivity and special aspects of coupling chemistry are being described.

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References

  • Abbas Rizvi SM, Song EY, Raja C, Beretov J, Morgenstern A, Apostolidis C, Russell PJ, Kearsley JH, Abbas K, Allen BJ (2008) Cancer Biol Ther 7:1547

    Google Scholar 

  • Aime S, Barge A, Botta M, Fasano M, Ayala JD, Bombieri G (1996) Inorg Chim Acta 246:423

    CAS  Google Scholar 

  • Albert R, Smith-Jones P, Stolz B, Simeon C, Knecht H, Bruns C, Pless J (1998) Bioorg Med Chem Lett 8:1207

    CAS  Google Scholar 

  • Alberto R, Nef W, Smith A, Kaden TA, Neuburger M, Zehnder M, Frey A, Abram U, Schubiger PA (1996) Inorg Chem 35:3420

    CAS  Google Scholar 

  • Alexander V (1995) Chem Rev 95:273

    CAS  Google Scholar 

  • Al-Nahhas A, Win Z, Szyszko T, Singh A, Nanni C, Fanti S, Rubello D (2007) Anticancer Res 27:4087

    CAS  Google Scholar 

  • Anderson CJ, Pajean TS, Edwards WB, Sherman EL, Rogers BE, Welch MJ (1995) J Nucl Med 36:2315

    CAS  Google Scholar 

  • Anderson CJ, Ferdani R (2009) Cancer Biother Radiopharm 24:379

    CAS  Google Scholar 

  • Anderson CJ, Dehdashti F, Cutler PD, Schwarz SW, Laforest R, Bass LA, Lewis JS, McCarthy DW (2001) J Nucl Med 42:213

    CAS  Google Scholar 

  • André JP, Maecke HR, Zehnder M, Macko L, Akyel KG (1998) Chem Commun 12:1301

    Google Scholar 

  • Antunes P, Ginj M, Zhang H, Waser B, Baum RP, Reubi JC, Maecke HR (2007a) Eur J Nucl Med Mol Imaging 34:982

    CAS  Google Scholar 

  • Antunes P, Ginj M, Walter MA, Chen J, Reubi JC, Maecke HR (2007b) Bioconjug Chem 18:84

    CAS  Google Scholar 

  • Boswell CA, Regino CAS, Baidoo KE, Wong KJ, Bumb A, Xu H, Milenic DE, Kelley JA, Lai CC, Brechbiel MW (2008) Bioconjug Chem 19:1476

    CAS  Google Scholar 

  • Breeman WAP, De Jong M, Visser TJ, Erion JL, Krenning EP (2003) Eur J Nucl Med 30:917

    CAS  Google Scholar 

  • Brechbiel MW (2008) Q J Nucl Med Mol Imaging 52:166

    CAS  Google Scholar 

  • Brechbiel MW, Gansow OA, Atcher RW, Schlom J, Esteban J, Simpson DE, Colcher D (1986) Inorg Chem 25:2772

    CAS  Google Scholar 

  • Brechbiel MW, Gansow OA (1991) Bioconjug Chem 2:187

    CAS  Google Scholar 

  • Brechbiel MW, Pippin CG, McMurry TJ, Milenic D, Roselli M, Colcher D, Gansow OA (1991) J Chem Soc Chem Commun 17:1169

    Google Scholar 

  • Brechbiel MW, Gansow OA, Pippin CG, Rogers RD, Planalp RP (1996) Inorg Chem 35:6343

    CAS  Google Scholar 

  • Broan CJ, Cox JPL, Craig AS, Kataky R, Parker D, Harrison A, Randall AM, Ferguson G (1991) J Chem Soc Perk T 2:87

    Google Scholar 

  • Brockmann J, Rösch F (1999) Radiochim Acta 87:79

    CAS  Google Scholar 

  • Busse S, Brockmann J, Rösch F (1999) J Labelled Compd Rad 42:300

    Google Scholar 

  • Cai H, Fissekis J, Conti PS (2009) Dalton Trans 27:5395

    Google Scholar 

  • Caravan P, Ellison JJ, McMurry TJ, Lauffer RB (1999) Chem Rev 99:2293

    CAS  Google Scholar 

  • Chappell LL, Rogers BE, Khazaeli MB, Mayo MS, Buchsbaum DJ, Brechbiel MW (1999) Bioorg Med Chem 7:2313

    CAS  Google Scholar 

  • Chappell LL, Deal KA, Dadachova E, Brechbiel MW (2000) Bioconjug Chem 11:510

    CAS  Google Scholar 

  • Chinn P, Braslawsky G, White C, Hanna N (2003) Cancer Immunol Immunother 52:257

    CAS  Google Scholar 

  • Chinol M, Bodei L, Cremonesi M, Paganelli G (2002) Sem Nucl Med 32:141

    Google Scholar 

  • Clifford T, Boswell CA, Biddlecombe GB, Lewis JS, Brechbiel MW (2006) J Med Chem 49:4297

    CAS  Google Scholar 

  • Cotton FA, Wilkinson G (1988) In: Cotton FA, Wilkinson G (eds) Advanced inorganic chemistry, 5th edn. New York, Wiley

    Google Scholar 

  • Cox JPL, Craig AS, Helps IM, Jankowski KJ, Parker D, Eaton MAW, Millican AT, Millar K, Beeley NRA, Boyce BA (1990) J Chem Soc Perk T 1:2567

    Google Scholar 

  • Cummins CH, Rutter EW, Fordyce WA (1991) Bioconjug Chem 2:180

    CAS  Google Scholar 

  • Cutler CS, Smith CJ, Ehrhardt GJ, Tyler TT, Jurisson SS, Deutsch E (2000) Cancer Biother Radiopharm 15:531

    CAS  Google Scholar 

  • Deal KA, Davis IA, Mirzadeh S, Kennel SJ, Brechbiel MW (1999) J Med Chem 42:2988

    CAS  Google Scholar 

  • De Jong M, Bakker WH, Krenning EP, Breeman WAP, van der Pluijm ME, Bernard BF, Visser TJ, Jermann E, Béhé M, Powell P, Mäcke HR (1997) Eur J Nucl Med 24:368

    Google Scholar 

  • Di Bartolo NM, Sargeson AM, Donlevy TM, Smith SV (2001) J Chem Soc Dalton Trans 15:2303

    Google Scholar 

  • Di Bartolo N, Sargeson AM, Smith SV (2006) Org Biomol Chem 4:3350

    Google Scholar 

  • Eberle AN, Mild G (2009) J Recept Signal T 29:1

    CAS  Google Scholar 

  • Eisenwiener KP, Powell P, Mäcke HR (2000) Bioorg Med Chem Lett 10:2133

    CAS  Google Scholar 

  • Eisenwiener KP, Prata MIM, Buschmann I, Zhang HW, Santos AC, Wenger S, Reubi JC, Mäcke HR (2002) Bioconjug Chem 13:530

    CAS  Google Scholar 

  • Fani M, André JP, Maecke HR (2008) Contrast Media Mol Imaging 3:67

    Google Scholar 

  • Fichna J, Janecka A (2003) Bioconjug Chem 14:3

    CAS  Google Scholar 

  • Forrer F, Waldherr C, Maecke HR, Mueller-Brand J (2006) Anticancer Res 26:703

    CAS  Google Scholar 

  • Fragogeorgi EA, Zikos C, Gourni E, Bouziotis P, Paravatou-Petsotas M, Loudos G, Mitsokapas N, Xanthopoulos S, Mavri-Vavayanni M, Livaniou E, Varvarigou AD, Archimandritis SC (2009) Bioconjug Chem 20:856

    CAS  Google Scholar 

  • Garmestani K, Yao Z, Zhang M, Wong K, Park CW, Pastan I, Carrasquillo JA, Brechbiel MW (2001) Nucl Med Biol 28:409

    CAS  Google Scholar 

  • Geue RJ, Hambley TW, Harrowfield JM, Sargeson AM, Snow MR (1984) J Am Chem Soc 106:5478

    CAS  Google Scholar 

  • Ginj M, Zhang H, Eisenwiener KP, Wild D, Schulz S, Rink H, Cescato R, Reubi JC, Maecke HR (2008) Clin Cancer Res 14:2019

    CAS  Google Scholar 

  • Good S (2006) PhD thesis, University of Basel, Faculty of Science

    Google Scholar 

  • Good S, Walter MA, Waser B, Wang X, Müller-Brand J, Béhé MP, Reubi JC, Maecke HR (2008) Eur J Nucl Med Mol Imaging 35:1868

    CAS  Google Scholar 

  • Gouin SG, Gestin JF, Joly K, Loussouarn A, Reliquet A, Meslin JC, Deniaud D (2002a) Tetrahedron 58:1131

    CAS  Google Scholar 

  • Gouin SG, Gestin J-F, Reliquet A, Meslin JC, Deniaud D (2002b) Tetrahedron Lett 43:3003

    CAS  Google Scholar 

  • Gyr T, Mäcke HR, Hennig M (1997) Angew Chem Int Ed Engl 36:2786

    CAS  Google Scholar 

  • Hancock RD (1989) Prog Inorg Chem 37:187

    CAS  Google Scholar 

  • Hancock RD, Martell AE (1989) Chem Rev 89:1875

    CAS  Google Scholar 

  • Harrison A, Walker C, Parker D (1991) Nucl Med Biol 18:469

    CAS  Google Scholar 

  • Hassfjell S, Brechbiel MW (2001) Chem Rev 101:2019

    CAS  Google Scholar 

  • Henze M, Schuhmacher J, Hipp P, Kowalski J, Becker DW, Doll J, Mäcke HR, Hofmann M, Debus J, Haberkorn U (2001) J Nucl Med 42:1053

    CAS  Google Scholar 

  • Heppeler A, Friodevaux S, Mäcke MR, Jermann E, Béhé M, Powell P, Hennig M (1999a) Chem Eur J 5:1974

    CAS  Google Scholar 

  • Heppeler A, Froidevaux S, Eberle AN, Maecke HR (2000) Curr Med Chem 7:971

    CAS  Google Scholar 

  • Heppeler A, Jermann E, Gyr T, Dyson RM, Ruser G, Hennig M, Neuburger M, Neuburger-Zehnder M, Kaden T, Maecke HR (1999b) In: Nicolini M, Mazzi U (eds) Technetium, rhenium and other metals in chemistry and nuclear medicine, vol 5. SGE Editioriali, Padua, pp 65–69

    Google Scholar 

  • Heppeler A, André JP, Buschmann I, Wang X, Reubi JC, Hennig M, Kaden TA, Maecke HR (2008) Chemistry 14:3026

    CAS  Google Scholar 

  • Hnatowich DJ, Layne WW, Childs RL, Lanteigne D, Davis MA, Griffin TW, Doherty PW (1983) Science 220:613

    CAS  Google Scholar 

  • Hoffmann M, Maecke H, Börner AR, Weckesser E, Schöffski P, Oei ML, Schumacher J, Henze M, Heppeler A, Meyer GJ, Knapp WH (2001) Eur J Nucl Med 28:1751

    Google Scholar 

  • Hsieh HP, Wu YT, Chen ST, Wang KT (1999) Bioorg Med Chem 7:1797

    CAS  Google Scholar 

  • Hu F, Cutler CS, Hoffman T, Sieckman G, Volkert WA, Jurisson SS (2002) Nucl Med Biol 29:423

    CAS  Google Scholar 

  • ICRP: International Commision on Radiological Protection (1983) Radionuclide transformations, ICRP Publication 38. Pergamon Press, Oxford

    Google Scholar 

  • Jamar F, Barone R, Mathieu I, Walrand S, Labar D, Carlier P, De Camps J, Schran H, Chen T, Smith MC, Bouterfa H, Valkema R, Krenning EP, Kvols LK, Pauwels S (2003) Eur J Nucl Med 30:510

    CAS  Google Scholar 

  • Jang YH, Blanco M, Dasgupta S, Keire DA, Shively JE, Goddard WA (1999) J Am Chem Soc 121:6142

    CAS  Google Scholar 

  • Jones-Wilson TM, Motekaitis RJ, Sun Y, Anderson CJ, Martell AE, Welch MJ (1995) Nucl Med Biol 22:859

    CAS  Google Scholar 

  • Jurcic JG, Larson SM, Sgouros G, McDevitt MR, Finn RD, Divgi CR, Ballangrud AM, Hamacher KA, Ma D, Humm JL, Brechbiel MW, Molinet R, Scheinberg DA (2002) Blood 100:1233

    CAS  Google Scholar 

  • Kennel SJ, Chappell LL, Dadachova K, Brechbiel MW, Lankford TK, Davis IA, Stabin M, Mirzadeh S (2000) Cancer Biother Radiopharm 15:235

    CAS  Google Scholar 

  • Kimura E, Fujioka H, Yatsunami A, Nihira H, Kodama M (1985) Chem Pharm Bull 33:655

    CAS  Google Scholar 

  • Kneifel S, Cordier D, Good S, Ionescu MC, Ghaffari A, Hofer S, Kretzschmar M, Tolnay M, Apostolidis C, Waser B, Arnold M, Mueller-Brand J, Maecke HR, Reubi JC, Merlo A (2006) Clin Cancer Res 12:3843

    CAS  Google Scholar 

  • Knör S, Modlinger A, Poethko T, Schottelius M, Wester HJ, Kessler H (2007) Chem Eur J 13:6082

    Google Scholar 

  • Kodama M, Koike T, Mahatma AB, Kimura E (1991) Inorg Chem 30:1270

    CAS  Google Scholar 

  • Kolb HC, Sharpless KB (2003) Drug Discov Today 8:1128

    CAS  Google Scholar 

  • Koop B, Sven N, Reske SN, Neumaier B (2007) Radiochim Acta 95:39

    CAS  Google Scholar 

  • Krejcarek GE, Tucker KL (1977) Biochem Biophys Res Commun 77:581

    CAS  Google Scholar 

  • Krenning EP, Bakker WH, Breeman WAP (1989) Lancet 1:242

    CAS  Google Scholar 

  • Kukis DL, De Nardo SJ, De Nardo GL, O’Donnell RT, Meares CF (1998) J Nucl Med 39:2105

    CAS  Google Scholar 

  • Kumar K, Chang CA, Francesconi LC, Dischino DD, Malley MF, Gougoutas JZ, Tweedle MF (1994) Inorg Chem 33:3567

    CAS  Google Scholar 

  • Kumar K, Chang CA, Tweedle MF (1993) Inorg Chem 32:587

    CAS  Google Scholar 

  • Kwekkeboom DJ, Bakker WH, Kooij PP, Konijnenberg MW, Srinivasan A, Erion JL, Schmidt MA, Bugaj JL, De Jong M, Krenning EP (2001) Eur J Nucl Med 28:1319

    CAS  Google Scholar 

  • Lamberts SWJ, Bakker WH, Reubi JC, Krenning EP (1990) N Engl J Med 323:1246

    CAS  Google Scholar 

  • Lewis MR, Kao JY, Anderson AL, Shively JE, Raubitschek A (2001) Bioconjug Chem 12:320

    CAS  Google Scholar 

  • Lewis MR, Shively JE (1998) Bioconjug Chem 9:72

    CAS  Google Scholar 

  • Liu S (2008) Adv Drug Deliv Rev 60:1347

    CAS  Google Scholar 

  • Liu Z, Li ZB, Cao Q, Liu S, Wang F, Chen X (2009) J Nucl Med 50:1168

    CAS  Google Scholar 

  • Liu S, Edwards DS (2001) Bioconjug Chem 12:7

    Google Scholar 

  • Liu S, Edwards DS (1999) Chem Rev 99:2235

    CAS  Google Scholar 

  • Luyt LG, Katzenellenbogen JA (2002) Bioconjug Chem 13:1140

    CAS  Google Scholar 

  • Ma MT, Karas JA, White JM, Scanlon D, Donnelly PS (2009) Chem Commun 14:3237

    Google Scholar 

  • Maecke HR, Riesen A, Ritter W (1989) J Nucl Med 30:1235

    CAS  Google Scholar 

  • Mäcke HR, Smith-Jones P, Maina T, Stolz B, Albert R, Bruns C, Reist H (1993) Horm Metab Res Suppl 27:12

    Google Scholar 

  • Mäcke HR, Good S (2002) In: Nicolini M, Mazzi U (eds) Technetium, rhenium and other metals in chemistry and nuclear medicine, vol 6. SGE Editoriali, Padua, pp 35–41

    Google Scholar 

  • Maecke HR, Hofmann M, Haberkorn U (2005) J Nucl Med 46:172S

    CAS  Google Scholar 

  • Mamat C, Ramenda T, Wuest FR (2009) Mini-Rev Org Chem 6:21

    CAS  Google Scholar 

  • McCarthy DW, Shefer RE, Klinkowstein RE, Bass LA, Margeneau WH, Cutler CS, Anderson CJ, Welch MJ (1997) Nucl Med Biol 24:35

    CAS  Google Scholar 

  • McDevitt MR, Ma D, Lai LT, Simon J, Borchardt P, Frank RK, Wu K, Pellegrini V, Curcio MJ, Miederer M, Bander NH, Scheinberg DA (2001) Science 294:1537

    CAS  Google Scholar 

  • McMurry TJ, Brechbiel M, Kumar K, Gansow OA (1992) Bioconjug Chem 3:108

    CAS  Google Scholar 

  • McMurry TJ, Brechbiel M, Wu C, Gansow OA (1993) Bioconjug Chem 4:236

    CAS  Google Scholar 

  • McMurry TJ, Pippin CG, Wu C, Deal KA, Brechbiel MW, Mirzadeh S, Gansow OA (1998) J Med Chem 41:3546

    CAS  Google Scholar 

  • Meijs WE, Herscheid JDM, Haisma HJ (1992) Appl Radiat Isot 43:1443

    CAS  Google Scholar 

  • Merrifield RB (1963) J Am Chem Soc 85:2149

    CAS  Google Scholar 

  • Mindt TL, Müller C, Stuker F, Salazar JF, Hohn A, Mueggler T, Rudin M, Schibli R (2009) Bioconjug Chem 20:1940

    CAS  Google Scholar 

  • Moi MK, Meares CF (1988) J Am Chem Soc 110:6266

    CAS  Google Scholar 

  • Moi MK, Yanuck M, Deshpande SV, Hope H, DeNardo SJ, Meares CF (1987) Inorg Chem 26:3458

    CAS  Google Scholar 

  • Moore DA, Fanwick PE, Welch MJ (1989) Inorg Chem 28:1504

    CAS  Google Scholar 

  • Nikula TK, McDevitt MR, Finn RD, Wu C, Kozak RW, Garmestani K, Brechbiel MW, Curcio MJ, Pippin CG, Tiffany-Jones L, Geerlings MW, Apostolidis C, Molinet R, Geerlings MW, Gansow OA, Scheinberg DA (1999) J Nucl Med 40:166

    CAS  Google Scholar 

  • Obata A, Kasamatsu S, McCarthy DW, Welch MJ, Saji H, Yonekura Y, Fujibayashi Y (2003) Nucl Med Biol 30:535

    CAS  Google Scholar 

  • Otte A, Jermann E, Behe M, Goetze M, Bucher HC, Roser HW, Heppeler A, Mueller-Brand J, Maecke HR (1997) Eur J Nucl Med 24:792

    CAS  Google Scholar 

  • Otte A, Mueller-Brand J, Dellas S, Nitzsche E, Herrmann R, Maecke H (1998) Lancet 351:417

    CAS  Google Scholar 

  • Ouadi A, Loussouarn A, Remaud P, Morandeau L, Apostolidis C, Musikas C, Faivre-Chauvet A, Gestin JF (2000) Tetrahedron Lett 41:7207

    CAS  Google Scholar 

  • Parry JJ, Kelly TS, Andrews R, Rogers BE (2007) Bioconjug Chem 18:1110

    CAS  Google Scholar 

  • Patel YC, Greenwood M, Panetta R, Hukovic N, Grigorakis S, Robertson LA, Srikant CB (1996) Metabolism 45:31

    CAS  Google Scholar 

  • Peterson JJ, Pak RH, Meares CF (1999) Bioconjug Chem 10:316

    CAS  Google Scholar 

  • Prasad V, Ambrosini V, Hommann M, Hoersch D, Fanti S, Baum RP (2010) Eur J Nucl Med Mol Imaging 37:67

    CAS  Google Scholar 

  • Prasanphanich AF, Nanda PK, Rold TL, Ma L, Lewis MR, Garrison JC, Hoffman TJ, Sieckman GL, Figueroa SD, Smith CJ (2007) Proc Natl Acad Sci U S A 104:12462

    CAS  Google Scholar 

  • Reichert DE, Lewis JS, Anderson CJ (1999) Coordin Chem Rev 184:3

    CAS  Google Scholar 

  • Reubi JC, Maecke HR (2008) J Nucl Med 49:1735

    CAS  Google Scholar 

  • Reubi JC (1995) J Nucl Med 36:1825

    CAS  Google Scholar 

  • Richman JE, Atkins TJ (1974) J Am Chem Soc 96:2268

    CAS  Google Scholar 

  • Rostovtsev VV, Green LG, Fokin VV, Sharpless KB (2002) Angew Chem Int Ed 41:2596

    CAS  Google Scholar 

  • Ruser G, Ritter W, Maecke HR (1990) Bioconjug Chem 1:345

    CAS  Google Scholar 

  • Safavy A, Smith DC, Bazooband A, Buchsbaum DJ (2002a) Bioconjug Chem 13:317

    CAS  Google Scholar 

  • Safavy A, Smith DC, Bazooband A, Buchsbaum DJ (2002b) Bioconjug Chem 13:327

    CAS  Google Scholar 

  • Sargeson AM (1996) Coord Chem Rev 151:89

    CAS  Google Scholar 

  • Schottelius M, Schwaiger M, Wester HJ (2003) Tetrahedron Lett 44:2393

    CAS  Google Scholar 

  • Schubiger PA, Alberto R, Smith A (1996) Bioconjug Chem 7:165

    CAS  Google Scholar 

  • Shannon RD (1976) Acta Crystallogr A 32:751

    Google Scholar 

  • Sherry AD, Brown RD, Geraldes CFGC, Koenig SH, Kuan KT, Spiller M (1989) Inorg Chem 28:620

    CAS  Google Scholar 

  • Shokeen M, Anderson CJ (2009) Acc Chem Res 42:832

    CAS  Google Scholar 

  • Sieving PF, Watson AD, Rocklage SM (1990) Bioconjug Chem 1:65

    CAS  Google Scholar 

  • Smith SV (2004) J Inorg Biochem 98:1874

    CAS  Google Scholar 

  • Smith-Jones PM, Fridrich R, Kaden TA, Novak-Hofer I, Siebold K, Tschudin D, Maecke HR (1991) Bioconjug Chem 2:415

    CAS  Google Scholar 

  • Smith-Jones PM, Stolz B, Albert R, Ruser G, Briner U, Maecke HR (1994) J Nucl Med 35:317

    CAS  Google Scholar 

  • Smith-Jones PM, Stolz B, Albert R, Ruser G, Briner U, Maecke HR (1998) Nucl Med Biol 25:181

    CAS  Google Scholar 

  • Sprague JE, Peng Y, Fiamengo AL, Woodin KS, Southwick EA, Weisman GR, Wong EH, Golen JA, Rheingold AL, Anderson CJ (2007) J Med Chem 50:2527

    CAS  Google Scholar 

  • Sprague JE, Peng Y, Sun X, Weisman GR, Wong EH, Achilefu S, Anderson CJ (2004) Clin Cancer Res 10:8674

    CAS  Google Scholar 

  • Stimmel JB, Kull FC Jr (1998) Nucl Med Biol 25:117

    CAS  Google Scholar 

  • Stolz B, Smith-Jones PM, Albert R, Reist H, Mäcke H, Bruns C (1994) Horm Metab Res 26:447

    Google Scholar 

  • Stolz B, Smith-Jones P, Albert R, Tolcsvai L, Briner U, Ruser G, Mäcke H, Weckbecker G, Bruns C (1996) Digestion 57(suppl 1):17

    CAS  Google Scholar 

  • Stolz B, Weckbecker G, Smith-Jones PM, Albert R, Friedrich R, Bruns C (1998) Eur J Nucl Med 25:668

    CAS  Google Scholar 

  • Sundberg MW, Meares CF, Goodwin DA, Diamanti CI (1974a) J Med Chem 17:1304

    CAS  Google Scholar 

  • Sundberg MW, Meares CF, Goodwin DA, Diamanti CI (1974b) Nature 250:587

    CAS  Google Scholar 

  • Tasker PA, Sklar L (1975) J Cryst Mol Struct 5:329

    CAS  Google Scholar 

  • Tornøe CW, Christensen C, Meldal M (2002) J Org Chem 67:3057

    Google Scholar 

  • Tóth È, Brücher E, Lázár I, Tóth I (1994) Inorg Chem 33:4070

    Google Scholar 

  • Velikyan I, Beyer GJ, LÃ¥ngström B (2004) Bioconjug Chem 15:554

    CAS  Google Scholar 

  • Velikyan I, Maecke HR, Langstrom B (2008) Bioconjug Chem 19:569

    CAS  Google Scholar 

  • Volkert WA, Goeckeler WF, Ehrhardt GJ, Ketring AR (1991) J Nucl Med 32:174

    CAS  Google Scholar 

  • Volkert WA, Hoffmann TJ (1999) Chem Rev 99:2269

    CAS  Google Scholar 

  • Wadas TJ, Wong EH, Weisman GR, Anderson CJ (2007) Curr Pharm Des 13:3

    CAS  Google Scholar 

  • Wadas TJ, Eiblmaier M, Zheleznyak A, Sherman CD, Ferdani R, Liang K, Achilefu S, Anderson CJ (2008) J Nucl Med 49:1819

    CAS  Google Scholar 

  • Waldherr C, Pless M, Maecke H, Schumacher T, Crazzolara A, Nitzsche E, Haldemann A, Mueller-Brand J (2002) J Nucl Med 43:610

    CAS  Google Scholar 

  • Weisman GR, Reed DP (1996) J Org Chem 61:5186

    CAS  Google Scholar 

  • Weisman GR, Rogers ME, Wong EH, Jasinski JP, Paight ES (1990) J Am Chem Soc 112:8604

    CAS  Google Scholar 

  • Weisman GR, Wong EH, Hill DC, Rogers ME, Reed DP (1996) J Chem Soc Chem Commun 8:947

    Google Scholar 

  • Westerberg DA, Carney PL, Rogers PJ, Kline SJ, Johnson DK (1989) J Med Chem 32:236

    CAS  Google Scholar 

  • Wilder RB, DeNardo GL, DeNardo SJ (1996) J Clin Oncol 14:1383

    CAS  Google Scholar 

  • Williams MA, Rapoport H (1993) J Org Chem 58:1151

    CAS  Google Scholar 

  • Williams MA, Rapoport H (1994) J Org Chem 59:3616

    CAS  Google Scholar 

  • Wong EH, Weisman GR, Hill DC, Reed DP, Rogers ME, Condon JS, Fagan MA, Calabrese JC, Lam KC, Guzei IA, Rheingold AL (2000) J Am Chem Soc 122:10561

    CAS  Google Scholar 

  • Wu C, Kobayashi H, Sun B, Yoo TM, Paik CH, Gansow OA, Carrasquillo JA, Pastan I, Brechbiel MW (1997) Bioorg Med Chem 5:1925

    CAS  Google Scholar 

  • Wu Y, Zhang X, Xiong Z, Cheng Z, Fisher DR, Liu S, Gambhir SS, Chen X (2005) J Nucl Med 46:1707

    CAS  Google Scholar 

  • Xua H, Baidooa KE, Wongb KJ, Brechbiel MW (2008) Bioorg Med Chem Lett 18:2679

    Google Scholar 

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Authors and Affiliations

  1. Clinic for Nuclear Medicine, University Hospital Freiburg, Hugstetterstrasse 55, D-79106, Freiburg, Germany

    Dr. M. Fani & Dr. H. R. Maecke

  2. Division of Radiological Chemistry, University Hospital Basel, Petersgraben 4, CH-4031, Basel, Switzerland

    Dr. S. Good

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  1. Dr. M. Fani
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  2. Dr. S. Good
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  3. Dr. H. R. Maecke
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Correspondence to M. Fani .

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Editors and Affiliations

  1. Institute of Chemistry, Eötvös Loránd University, 32, Budapest, 1518, Hungary

    Attila Vértes (Professor Emeritus) & Sándor Nagy (Professor) (Professor Emeritus) &  (Professor)

  2. Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri út 59-67, Budapest, 1025, Hungary

    Zoltán Klencsár (Dr.) (Dr.)

  3. Institute of Nuclear Research (ATOMKI), Hungarian Academy of Sciences, 51, Debrecen, 4001, Hungary

    Rezső G. Lovas (Professor) (Professor)

  4. Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Fritz-Strassmann-Weg 2, 55128, Mainz, Germany

    Frank Rösch (Professor) (Professor)

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© 2011 Springer Science+Business Media B.V.

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Fani, M., Good, S., Maecke, H.R. (2011). Radiometals (non-Tc, non-Re) and Bifunctional Labeling Chemistry. In: Vértes, A., Nagy, S., Klencsár, Z., Lovas, R.G., Rösch, F. (eds) Handbook of Nuclear Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0720-2_45

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