Abstract
Any discussion of the neurobiology of vertebrate locomotion would be remiss without some mention of the contribution made by the study of invertebrates. After all the problems of locomotion (pattern generation, spatial and temporal coordination, and sensory modulation) are common to both groups. Perhaps similar neural mechanisms have evolved to cope with these common conditions. Certainly there is ample evidence in both groups that the generation of rhythmic neural activity underlying cyclic locomotor patterns can be attributed to “central pattern generator” (CPG) networks (Delcomyn, 1980). If we are to understand how locomotor patterns are generated and controlled a necessary step will be to understand how CPG networks produce spatially and temporally coordinated activity. In particular what are the cellular and synaptic mechanisms involved in motor pattern generation?
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References
Dekin, M.S. and Getting, P.A. (1984). Firing pattern of neurons in the nucleus tractus solitarious: Modulation by membrane hyperpolarization. Brain Res., 324, 180–184.
Dekin, M.S., Richerson, G.B. and Getting, P.A. (1985). Thyrotropin releasing hormone induces rhythmic bursting in neurons of the nucleus tractus solitarius. Science (in press).
Eisen, J.S. and Marder, E. (1984). A mechanism for the production of phase shifts in a pattern generator. J. Neurophysiol., 51 1375–1393.
Friesen, W.O. and Stent, G.S. (1977). Generation of a locomotory rhythm by a neural network of recurrent cyclic inhibition. Biol. Cyber., 28, 27–40.
Getting, P.A. (1981). Mechanisms of pattern generation underlying swimming in Tritonia. I. Neuronal network formed by monosynaptic connections. J. Neurophysiol., 46, 65–79
Getting, P.A. (1983a). Mechanisms of pattern generation underlying swimming in Tritonia. II. Network reconstruction. J. Neurophysiol., 49, 1017–1035.
Getting, P.A. (1983b). Mechanisms of pattern generation underlying swimming in Tritonia. III. Intrinsic and synaptic mechanisms for delayed excitation. J. Neurophysiol., 49, 1036–1050.
Getting, P.A. (1983c). Neural control of swimming in Tritonia. In Neural Origin of Rhythmic Movements, (eds. A. Roberts and B.L. Roberts). Soc. Exp. Biol. Symp., 37, Cambridge University Press, Cambridge.
Getting, P.A. (1985). Comparative analysis of invertebrate central pattern generators. In Neural Control of Rhythmic Movements. (eds. A.H. Cohen, S. Rossignol, and S. Grillner). Wiley, NY (in press).
Getting, P.A. and Dekin, M.S. (1985a). Mechanisms of pattern generation underlying swimming in Tritonia. IV. Gating of a central pattern generator. J. Neurophysiol., 52, 466–480.
Getting, P.A. and Dekin, M.S. (1985b). Tritonia swimming: A model system for integration within rhythmic motor systems. In Model Networks and Behavior, (ed. A.I. Selverston). Plenum Press, NY.
Getting, P.A., Lennard, P.R. and Hume, R.I. (1980). Central pattern generator mediating swimming in Tritonia. I. Identification and synaptic interactions. J. Neurophysiol., 44, 151–164.
Grillner, S., Wallen, P., McClellan, A., Sigvardt, K., Williams, T. and Feldman, J. (1983). The neural generation of locomotion in the lamprey: An incomplete account. In Neural Origin of Rhythmic Movements, (eds. A. Roberts and B.L. Roberts). Soc. Exp. Biol. Symp., 37, Cambridge University Press, Cambridge.
Grillner, S. and Wallen, P. (1985). Central pattern generators for locomotion, with special reference to vertebrates. Ann. Rev. Neurosci., 8, 233–261.
Harris-Warrick, R.M. (1985). Chemical modulation of central pattern generators. In Neural Control of Rhythmic Movements. (eds. A.H. Cohen, S. Rossignol, and S. Grillner). Wiley, NY (in press).
Hume, R.I., Getting, P.A. and Del Beccaro, M.A. (1982). Motor organization of Tritonia swimming. I. Quantitative analysis of swim behavior and flexion neuron firing patterns. J. Neurophysiol., 47, 60–74.
Hume, R.I. and Getting, P.A. (1982). Motor organization of Tritonia swimming. III. Contribution of intrinsic membrane properties to flexion neuron burst formation. J. Neurophysiol., 47, 91–102.
Kerkut, G. and Wheal, H. eds. (1981). Electrophysiology of Isolated Mammalian CNS Preparations. Academic Press, London.
Kristan, W.B. Jr. (1980). Generation of rhythmic motor patterns. In Information Processing in the Nervous System. (eds. H.M. Pinsker and W.D. Willis, Jr.). Raven Press, N.Y.
Landmesser, L.T. and O’Donovan, M.J. (1984). Activation patterns of embryonic chick hind limb muscles recorded in ovo and in an isolated spinal cord preparation. J. Physiol., 347, 189–204.
Lennard, P.R., Getting, P.A. and Hume, R.I. (1980). Central pattern generator mediating swimming in Tritonia. II. Initiation, maintenance, and termination. J. Neurophysiol., 44, 165–173.
Llinas, R., Yarom, Y. and Sugimori, M. (1981). The isolated mammalian brain in vitro: A new technique for the analysis of the electrical activity of neuronal circuit function. Fed. Proc, 40, 2240–2245.
Miller, J.P. and Selverston, A.I. (1979). Rapid killing of single neurons by irradiation of intracellularly injected dyes. Science, 206, 702–704.
Miller, J.P. and Selverston, A.I. (1982). Mechanisms underlying pattern generation in lobster stomatogastric ganglion as determined by selective inactivation of identified neurons. II. Oscillatory properties of pyloric neurons. J. Neurophysiol., 48, 1378–1391.
Nagy, F. and Dickinson, P.S. (1983). Control of a central pattern generator by an identified modulatory interneuron in Crustacea. I. Modulation of the pyloric motor output. J. Exp. Biol., 105, 33–58.
Richerson, G.B. and Getting, P.A. (1984). Respiratory activity in a perfused guinea pig brain/spinal cord preparation. Neurosci. Abstr., 10, 745.
Roberts, A. and Roberts, B.L., eds. (1983), Neural Origin of Rhythmic Movements. Soc. Exp. Biol. Symp., 37, Cambridge University Press, Cambridge.
Roberts, A., Soffe, S.R., Clarke, J.D.W. and Dale, W. (1983). Initiation and control of swimming in amphibian embryos. In Neural Origin of Rhythmic Movements, (eds. A. Roberts and B.L. Roberts). Soc. Exp. Biol. Symp., 37, Cambridge University Press, Cambridge.
Rovainen, C.M. (1983). Identified neurons in the lamprey spinal cord and their roles in fictive swimming. In Neural Origin of Rhythmic Movements, (eds. A. Roberts and B.L. Roberts). Soc. Exp. Biol. Symp., 37, Cambridge University Press, Cambridge.
Russell, D.F. and Hartline, D.K. (1978). Bursting neural networks: A re-examination. Science, 200, 453–456.
Selverston, A. I., ed. (1985). Model Networks and Behavior. Plenum Press, NY (in press).
Selverston, A.I., Miller, J.P. and Wadepuhl, M. (1983). Cooperative mechanisms for the production of rhythmic movements. In Neural Origin of Rhythmic Movements, (eds. A. Roberts and B.L. Roberts). Soc. Exp. Biol. Symp., 37, Cambridge University Press, Cambridge.
Selverston, A.I., and Moulin, M. (1985). Oscillatory neural networks. Ann. Rev. Physiol., 47, 29–48.
Sigvardt, K.A. and Grillner, S. (1981). Spinal neuronal activity during fictive locomotion in the lamprey. Neurosci. Abstr., 7, 362.
Speck, D.F. and Feldman, J.L. (1982). The effects of microstimulation and microlessions in the ventral and dorsal respiratory groups in medulla of cat. J. Neurosci., 2, 744–757.
Stein, P.S.G. (1983). The vertebrate scratch reflex. In Neural Origin of Rhythmic Movements, (eds. A. Roberts and B.L. Roberts). Soc. Exp. Biol. Symp., 37, Cambridge University Press, Cambridge.
Willows, A.O.D. (1967). Behavioral acts elicted by stimulation of single, identifiable brain cells. Science, 157, 570–574.
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© 1986 The Wenner-Gren Center
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Getting, P.A. (1986). Understanding Central Pattern Generators: Insights Gained from the Study of Invertebrate Systems. In: Grillner, S., Stein, P.S.G., Stuart, D.G., Forssberg, H., Herman, R.M. (eds) Neurobiology of Vertebrate Locomotion. Wenner-Gren Center International Symposium Series. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-09148-5_16
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DOI: https://doi.org/10.1007/978-1-349-09148-5_16
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