Abstract
The overall results of the various assays used to investigate the biological activity of benzidine (BZD), 4,4″-diaminoterphenyl (DAT), 4-dimethylaminoazobenzene (DAB) and 4-cyanodimethylaniline (CDA) are shown in table 1. The results are presented in the form of positive and negative responses for each assay displayed in terms of the increasing phylogenetic complexity. Because of the inevitable variation in the number of assays performed for each test, no attempt has been made to quantify the magnitude of positive and negative responses in this table. When displayed in this format, the table presents a complex picture which makes the assessment of the genotoxicity of these chemicals a difficult task. To clarify the database and to aid our assessment of the results it has been necessary, therefore, to contract the overall individual data points used for evaluation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Notes
Ashby, J., Styles, J.A. and Paton, D. (1980). Studies in vitro to discern the structural requirements for carcinogenicity in analogues of the carcinogen 4-dimethylaminoazobenzene (Butter Yellow). Carcinogenesis 1: 1–7
Ashby, J., de Serres, F.J., Draper, M., Ishidate, M., Margalin, B., Matter, B. and Shelby, M. (1985) Overview and conclusions of the study. In Collaborative Short-term Tests. Elsevier/ North Holland
de Serres, F.J. and Hoffman, G.R. (1981). Summary report on the performance of yeast assays. In Evaluation of Short-term Tests for Carcinogens (Progress in Mutation Research Ser. Vol.1) (eds. F.J. de Serres and J. Ashby). Elsevier/ North Holland, pp.68–71
Kelly, D. and Parry, J.M. (1983). Metabolic activation by cytochrome P450/P448 in the yeast Saccharomyces cerevisiae. Mutation Res. 108: 147–158
Martin, C.N. and McDermid, A.C. (1981). Testing of 42 coded compounds for their ability to induce unscheduled DNA repair synthesis in HeLa cells. In Evalution of Short-term Tests for Carcinogens (Progress in Mutation Research Ser. Vol.1) (eds. F.J. de Serres and J. Ashby). Elsevier/ North Holland. pp.533–537
Parodi, S., Carlo, P., Martelli, A., Taningher, M., Finollo, R., Pala, M. and Giaretti, W. (1981). A circular oscillating viscometer. J. Mol. Biol. 147: 501–521
Parodi, S. Balbi, C, Abelmoschi, M.L., Pala, P. and Santi, T.L. (1983). Studies on DNA damage: discordant responses of rate of DNA disentanglement (viscometrically evaluated) and alkaline elution rate, obtained for several compounds. Cell Biophys. Eng. 3: 285–300
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1985 United Kingdom Environmental Mutagen Society
About this chapter
Cite this chapter
Parry, J.M., Arlett, C.F., Ashby, J. (1985). An Overview of the Results of the in vivo and in vitro Test Systems Used to Assay the Genotoxicity of BZD, DAT, DAB and CDA in the Second UKEMS Collaborative Study. In: Parry, J.M., Arlett, C.F. (eds) Comparative Genetic Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07901-8_69
Download citation
DOI: https://doi.org/10.1007/978-1-349-07901-8_69
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-07903-2
Online ISBN: 978-1-349-07901-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)