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Experimental and Preclinical Tools to Explore the Main Neurological Impacts of Brain Irradiation: Current Insights and Perspectives

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Brain Tumors

Part of the book series: Neuromethods ((NM,volume 158))

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Abstract

Radiation therapy is a powerful tool in the treatment of primary and metastatic cancers of the brain. However, brain tissue tolerance is limited, and radiation doses must be tailored to minimize deleterious effects on the nervous system. Due to improved treatments, including radiotherapy techniques, many patients with brain tumors survive longer, but they experience late effects of radiotherapy, especially cognitive decline, for which no efficient treatment is currently available. Improving the prevention and treatment of radiation-induced neurological defects first needs to better characterize radiation injuries in brain cells and tissues. Rodent models have been widely used for this.

Here, observations from patients will be reviewed briefly as an introduction, mainly regarding clinical cognitive defects and anatomical alterations using magnetic resonance imaging (MRI). This limited descriptive clinical knowledge addresses many questions that arise in preclinical models regarding understanding the mechanism of radiation-induced brain dysfunction. From this perspective, we next present methods to characterize radiation-induced neurogenesis alterations in adult mice and then detail how MRI could be used as a powerful tool to explore these alterations.

Laura Mouton and Monica Ribeiro are co-first authors.

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Authors and Affiliations

  1. Laboratoire de RadioPathologie, UMRE008/U1274, Inserm, Université de Paris, Université Paris-Saclay, CEA, Fontenay-aux Roses, France

    Laura Mouton, Marc-André Mouthon & François D. Boussin

  2. NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France

    Laura Mouton, Fawzi Boumezbeur & Denis Le Bihan

  3. Centre Borelli, Université Paris-Saclay, Ecole Normale Supérieure Paris-saclay, Service de Santé des Armées, CNRS, Université de Paris, Paris, France

    Monica Ribeiro & Damien Ricard

  4. Service de Neurologie, Service de Santé des Armées, Hôpital d’Instruction des Armées Percy, Clamart, France

    Damien Ricard

  5. Service de Santé des Armées, Ecole du Val-de-Grâce, Paris, France

    Damien Ricard

  6. Département d’Oncologie Radiothérapie, Institut Curie, Paris, France

    Pierre Verrelle

  7. UMR 9187/U1196 (CMIB), Institut Curie, Orsay, France

    Pierre Verrelle

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  1. Laura Mouton
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  2. Monica Ribeiro
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  3. Marc-André Mouthon
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  4. Fawzi Boumezbeur
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  5. Denis Le Bihan
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  6. Damien Ricard
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  7. François D. Boussin
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  8. Pierre Verrelle
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Corresponding author

Correspondence to Laura Mouton .

Editor information

Editors and Affiliations

  1. INSERM U1021 - CNRS UMR3347 Institut Curie Research Center, Orsay, France

    Giorgio Seano

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Mouton, L. et al. (2021). Experimental and Preclinical Tools to Explore the Main Neurological Impacts of Brain Irradiation: Current Insights and Perspectives. In: Seano, G. (eds) Brain Tumors. Neuromethods, vol 158. Springer, New York, NY. https://doi.org/10.1007/978-1-0716-0856-2_11

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  • DOI: https://doi.org/10.1007/978-1-0716-0856-2_11

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