Abstract
The HLA-DR alleles, DRB1*0401, *0402, *0405, *0101 and *1402, which share an amino acid sequence EQR(K)RAA in the DRB1 chain, have been linked with a susceptibility to develop rheumatoid arthritis.
It has been suggested that an environmental factor interacting with a genetic predisposition contributes to the pathogenesis of rheumatoid arthritis and studies from our group have suggested that antigens present in the urinary microbe Proteus mirabilis are somehow involved in the pathology of this disease.
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Ebringer, A. (2011). Molecular Similarity Between the Rheumatoid Arthritis Associated Motif EQKRAA and Structurally Related Sequences of Proteus . In: Rheumatoid Arthritis and Proteus. Springer, London. https://doi.org/10.1007/978-0-85729-950-5_16
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DOI: https://doi.org/10.1007/978-0-85729-950-5_16
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