Abstract
Diaphysis = shaft; epiphysis = growth plate and end of bone; metaphysis = conical portion between diaphysis and epiphysis. Prevalence: Osteosarcoma > chondrosarcoma > Ewing’s > malignant fibrous histiocytoma (MFH). Sixty percent cases occur between 10 and 20 years of age (most active age of skeletal growth). Eighty percent cases in long bones until epiphyseal closure (then ∼occur with appendicular skeleton). In patients >60 years, >50% cases arise from other conditions (i.e., Paget’s disease, fibrous dysplasia) → poor chemo response. Osteosarcoma: Malignant osteoid is hallmark (not seen in chondrosarcoma). Most common bone tumor in children. Seventy-five percent present in metaphyses of long bones with local pain/swelling. Eighty-five percent are grades 3–4. Osteosarcoma arising as second malignancy s/p chemo or RT does not necessarily have worse prognosis, but controversial. Associated with Li-Fraumeni Syndrome (p53) and retinoblastoma. Periosteal (juxtacortical) osteosarcomas are usually low-grade, localized with rare DM. Most present in popliteal fossa. Eighty to ninety percent curable with surgery alone. Osteosarcoma: Most common in femur > tibia > humerus. DM most common in lung > bone/BM. Chondrosarcoma: ∼25% of all primary bone cancers. Most common in the femur. Frequent local recurrence, DM less common than osteosarcoma. 1/3 are high-grade. MFH: Very aggressive locally with frequent DM. Often presents with fracture. Fibrosarcoma: High-grade, behaves like osteosarcoma. Commonly presents with fractures. Chordoma: Physaliferous cell (“bubbly cell”) is hallmark. Most often in sacrococcygeal area, base of skull, and spine. Presentation is location specific. Giant cell tumors = giant multinucleated osteoclast cells. Only 8–15% are malignant. Cyst formation, hemorrhage, necrosis are important with regard to radiosensitivity. Frequent LR (45–60%).Lung metastases common in osteosarcoma, chondrosarcoma, MFH.
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References
DeLaney TF, Park L, Goldberg SI, et al. Radiotherapy for local control of osteosarcoma. Int J Radiat Oncol Biol Phys 2005;61:492-498.
Eilber F, Giuliano A, Eckardt J, et al. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol 1987;5:21-26.
Link MP, Goorin AM, Miser AW, et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med 1986;314:1600-1606.
Machak GN, Tkachev SI, Solovyev YN, et al. Neoadjuvant chemotherapy and local radiotherapy for high-grade osteosarcoma of the extremities. Mayo Clin Proc 2003;78:147-155.
Ozaki T, Flege S, Kevric M, et al. Osteosarcoma of the pelvis: experience of the Cooperative Osteosarcoma Study Group. J Clin Oncol 2003;21:334-341.
Wagner TD, Kobayashi W, Dean S, et al. Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone. Int J Radiat Oncol Biol Phys 2009;73:259-266.
Further Reading
Bramwell VH, Burgers M, Sneath R, et al. A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup. J Clin Oncol 1992;10:1579-1591.
Burgers JM, van Glabbeke M, Busson A, et al. Osteosarcoma of the limbs. Report of the EORTC-SIOP 03 trial 20781 investigating the value of adjuvant treatment with chemotherapy and/or prophylactic lung irradiation. Cancer 1988;61:1024-1031.
McNaney D, Lindberg RD, Ayala AG, et al. Fifteen year radiotherapy experience with chondrosarcoma of bone. Int J Radiat Oncol Biol Phys 1982;8: 187-190.
Montemaggi P BW, Horowitz SM. Bone. In: Perez CA, Brady LW, Halperin ED, Schmidt-Ullrich RK, editors. Principles and practice of radiation oncology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2004. pp 2168-2184.
Romero J, Cardenes H, la Torre A, et al. Chordoma: results of radiation therapy in eighteen patients. Radiother Oncol 1993;29:27-32.
Schecter NR LV. The Bone. In: Cox JD, Ang KK, editors. Radiation Oncology: Rationale, technique, results. 8th ed. St. Louis: Mosby; 2003. pp. 857-883. 2003.
Schoenthaler R, Castro JR, Petti PL, et al. Charged particle irradiation of sacral chordomas. Int J Radiat Oncol Biol Phys 1993;26:291-298.
Schupak K. Sarcomas of Bone. In: Leibel SA, Phillips TL, editors. Textbook of Radiation Oncology. 2nd ed. Philadelphia: Saunders; 2004. pp. 1363-1374.
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Kaprealian, T., Lee, B., Nakamura, J.L. (2010). Bone Tumors. In: Hansen, E., Roach, M. (eds) Handbook of Evidence-Based Radiation Oncology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92988-0_39
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DOI: https://doi.org/10.1007/978-0-387-92988-0_39
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