Skip to main content
SpringerLink
Log in

Cutaneous Lymphomas

  • Chapter
  • First Online:
Handbook of Evidence-Based Radiation Oncology

  • 2704 Accesses

Abstract

PEARLS Primary cutaneous lymphomas (PCL) are subdivided according to cell lineage. These include cutaneous B-cell lymphomas (CBCL) – 30% and cutaneous T-cell lymphomas (CTCL) – 70%. Overall, 1–1.5 new cases per 100,000/year. Annual age-adjusted incidence of CBCL was 4 per million; CTCL was 6 per million persons (Hoppe et al. 2004; Yahalom et al. 2004). Skin is the most common extranodal site of non-Hodgkin’s lymphoma (NHL), representing 2% of new cases of NHL. Affects older adults (55–60 years), 2:1 male predominance, blacks > whites. Hypothesized links with environmental factors or viral etiology not substantiated (de Jong et al. 2008) Presentation: skin lesions, but long natural history. Median time from skin lesion to diagnosis ∼5 years. Sézary cells: malignant T-cells. Sézary syndrome: erythroderma, lymphadenopathy, and Sézary cells in peripheral blood. Treatment should be tailored to specific subtype of PCL. Unlike other NHL’s, which use the Ann Arbor staging system, Mycosis fungoides/Sézary syndrome (MF/SS) uses a TNM staging system that correlates to prognosis (Kim et al. 2007; Horwitz et al. 2008). EORTC and WHO have classification schemes as well (Willemze et al. 2005; Golling et al. 2008).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

REFERENCES

REFERENCES

  • Olsen E, Vonderheid E, Pimpinelli N, et al. Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for cutaneous lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood. 2007;110:1713-1722.

    Article  PubMed  CAS  Google Scholar 

  • Sarris AH, Braunschweig I, et al. Primary cutaneous non-Hodgkin’s lymphoma of Ann Arbor stage I: preferential cutaneous relapses but high cure rate with doxorubicin-based therapy. J Clin Oncol. 2001;19(2):398-405.

    PubMed  CAS  Google Scholar 

  • Senff NJ, Hoefnagel JJ, Neelis KJ, et al. for the Dutch Cutaneous Lymphoma Group. Results of radiotherapy in 153 primary cutaneous B-cell lymphomas classified according to the WHO-EORTC classification. Arch Dermatol. 2007;143(12):1520-1526.

    Google Scholar 

  • Willemze R, Jaffe ES, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105(10): 3768-3785.

    Article  PubMed  CAS  Google Scholar 

Further Readings

  • Carter J, Zug K. Phototherapy for cutaneous T-cell lymphoma: Online survey and literature review. J Am Acad Dermatol. 2009;60:39-50.

    Article  PubMed  Google Scholar 

  • de Jong D, Vasmel W, de Boer JP, et al. Anaplastic large-cell lymphoma in women with breast implants. JAMA. 2008;300(17):2030-2035.

    Article  PubMed  Google Scholar 

  • Golling P, Cozzio A, Dummer R, et al. Primary cutaneous B-cell lymphomas – clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome. Leuk Lymphoma. 2008;49(6):1094-1103.

    Article  PubMed  Google Scholar 

  • Hoppe RT, Kim Y. Mycosis Fungiodes. In: Leibel SA, Phillips TL, editors. Textbook of radiation oncology. 2nd ed. Philadelphia: Saunders; 2004. pp. 1417-1431.

    Google Scholar 

  • Horwitz S, Olsen E, Duvic M, et al. Review of the treatment of mycosis fungoides and Sézary syndrome: a stage-based approach. JNCCN. 2008;6:436-442.

    PubMed  Google Scholar 

  • Kim Y, Willemze R, Pimpinelli N, et al. TNM classification system for cutaneous lymphomas other than mycosis fungoides and sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC). Blood. 2007;110:479-484.

    Article  PubMed  CAS  Google Scholar 

  • National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology v1.2010: Multiple Myeloma. Available at http://www.nccn.org/professionals/physician_gls/PDF/nhl.pdf. Accessed on March 3, 2010.

  • Yahalom J. Non-Hodgkin’s lymphoma. In: Leibel SA, Phillips TL, editors. Textbook of radiation oncology. 2nd ed. Philadelphia: Saunders; 2004. pp. 1393-1416.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Radiation Oncology, Kaiser Permanente, San Francisco, CA, USA

    Amy Gillis MD

  2. Radiation Oncology, University of California San Francisco, San Francisco, CA, USA

    Thomas T. Bui MD

  3. Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA

    Mack Roach III MD

Authors
  1. Amy Gillis MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas T. Bui MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mack Roach III MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Div. Radiation Oncology, Oregon Clinic, SW. Barnes Rd. 9205, Portland, 97225, Oregon, USA

    Eric K. Hansen

  2. Department of Radiation Oncology, University of California, San Francisco, Divisadero Street, Suite H-1031 1600, San Francisco, 94143, California, USA

    Mack Roach

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag New York

About this chapter

Cite this chapter

Gillis, A., Bui, T.T., Roach, M. (2010). Cutaneous Lymphomas. In: Hansen, E., Roach, M. (eds) Handbook of Evidence-Based Radiation Oncology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92988-0_37

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-92988-0_37

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-92987-3

  • Online ISBN: 978-0-387-92988-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation