Abstract
There are three major technical components of positron emission tomography (PET): PET scanner, cyclotron production of radiopharmaceuticals, and biological assays of normal and disease processes. A historical perspective from the early development stages through today is given for each of these technology areas, as well as some predictions for the future. Details of the technologies are given on PET scanners and cameras in Chapter 2 and for cyclotron production of radiopharmaceuticals in Chapter 3.
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References
Shields AF, Grierson JR, Dohmen BM, et al.: Imaging proliferation in vivo with [F-18]FLT and positron emission tomography. Nature Medicine 1998;4:1334–1336.
Phelps ME, Hoffman E, Mullani N, et al.: Application of annihilation coincidence detection to transaxial reconstruction tomography. J Nucl Med 1975;16:210–224.
Phelps ME, Cherry SR: The changing design of positron imaging systems. Clin Pos Imaging 1998;1:31–45.
Patton JA: Instrumentation for coincidence imaging with multihead scintillation cameras. J Nucl Med 2000;30:239–254.
Phelps ME: PET: The merger of biology and imaging into molecular imaging. J Nucl Med 2000;41:661–681.
Phelps ME: Positron emission tomography provides molecular imaging of biological processes. Proc Natl Acad Sci (USA) 2000;97:9226–9233.
Sokoloff L, Reivich M, Kennedy C, et al.: The (14C) deoxyglucose method for the measurement of local glucose utilization: Theory, procedure and normal values in the conscious and anesthetized albino rat. J Neurochem 1977;28:897–916.
Ido T, Wan C-N, Casella JS, et al.: Labeled 2-deoxy-D-glucose analogs: F labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose. J Labeled Compds Radiopharmacol 1978;14:175–183.
Phelps ME, Huang SC, Hoffman EJ, et al.:Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-deoxy-D-glucose: Validation of method. Ann Neurol 1979;6:371–388.
Reivich M, Kuhl D, Wolf A, et al.: The (18F)fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 1979;44:117–127.
Huang SC, Phelps ME, Hoffman EJ, et al.: Noninvasive determination of local cerebral metabolic rate of glucose in man. Am J Physiol 1980;238:E69–E82.
Woodward GE, Hudson MT: The effect of 2-deoxy-D-glucose in glycolysis and respiration of tumor and normal tissues. Cancer Res 1954;14: 599–605.
Fowler JS, Wolf AP: Positron emitter-labeled compounds: Priorities and programs, in Phelps ME, Mazziotta JC, Schelbert HR (eds): Positron Emission Tomography and Autoradiography: Principles and Applications. New York: Raven Press, 1986, pp 391–450.
Burnham C, Brownell G: A multi-crystal positron camera. IEEE Trans Nucl Sci 1972;19:201–205.
Brownell G, Burnham C: MGH positron camera, in Freedman G (ed): Tomographic Imaging in Nuclear Medicine. New York: Society of Nuclear Medicine, 1973, pp 154–164.
Muehllehner G, Buchin M, Dudek J: Performance parameters of a positron imaging camera. IEEE Trans Nucl Sci 1976;NS-23:528–537.
Robertson J, Marr R, Roseblum B: Thirty-two crystal positron transverse section detector, in Freedman G (ed): Tomographic Imaging in Nuclear Medicine. New York: Society of Nuclear Medicine, 1973, pp 151–153.
Kuhl D, Edwards R: Cylindrical and section radioisotope scanning of the liver and brain. Radiology 1964;83:926–935.
Hounsfield G, Ambrose J: Computerized transverse axial scanning (tomography). Part I: Description of system. Part II: Clinical applications. Br J Radiol 1973;46:1016–1047.
McCormack A: Reconstruction of densities from their projections, with applications to radiological physics. Phys Med Biol 1973;18:195–207.
Phelps ME, Hoffman E, Mullani N, et al.: Design considerations for a positron emission transaxial tomograph (PETT III). IEEE 1976;NS-23:516–522.
Hoffman E, Phelps ME, Mullani N, et al.: Design and performance characteristics of a whole body transaxial tomograph. J Nucl Med 1976;17:493–503.
Satyamurthy N, Barrio J, Phelps ME: Electronic generators for the production of positron-emitted labeled radiopharmaceuticals: Where would PET be without them? Clin Positron Imaging 1999;2:233–253.
Cherry SR, Shao Y, Silverman RW, et al.: MicroPET: A high resolution PET scanner for imaging small animals. IEEE Trans Nucl Sci 1997;44:1109–1113.
Chatziioannou AF, Cherry SR, Shao Y, et al.: Performance evaluation of microPET: A high resolution lutetium oxyorthosilicate PET scanner for animal imaging. J Nucl Med 1999;40:1164–1175.
Phelps ME, Hoffman E, Huang S, et al.: A new computerized tomographic imaging system for positron emitting radiopharmaceuticals. J Nucl Med 1978;19:635–647.
Hoffman E, Ricci A, van der Stee LMAM, et al.: ECAT III—Basic design considerations. IEEE Trans Nucl Sci 1983;NS-30:729–733.
Brownell G, Burkham C, Chesler D, et al.: Transverse section imaging of radionuclide distributions in heart, lung and brain, inTer Pogossian M, Phelps M, Brownell G, Cox J, Davis D, Evans R (eds): Reconstruction Tomography in Diagnostic Radiology and Nuclear Medicine. Baltimore: University Park Press, 1977, pp 293–308.
Cho Z, Chan J, Eriksson L: Circular ring transverse axial positron camera for 3-dimensional reconstruction of radionuclide distribution. IEEE Trans Nucl Sci 1976;NS-23:613–622.
Cho Z, Farukhi M: BGO as a potential scintillation detector in positron cameras. J Nucl Med 1977;18:840–844.
Derenzo SE, Budinger T, Cahoon J: High resolution computed tomography of positron emitters. IEEE Nucl Sci 1977;NS-24:544–558.
Derenzo SE: Monte Carlo calculations of the detection efficiency of arrays of NaI(Tl), BGO, CsF, Ge, and plastic detectors for 511keV photons. IEEE Trans Nucl Sci 1981;NS-28:131–136.
Derenzo SE, Budinger TF, Huessman RH, et al.: Imaging properties of a positron tomograph with 280 BGO crystals. IEEE Trans Nucl Sci 1981;NS-28:81–89.
Casey M, Nutt R: A multislice two-dimensional BGO detector system for PET. IEEE Trans Nucl Sci 1986;NS-33:760–763.
Guerrero T, Hoffman E, Dahlbom M, et al.: Characterization of a whole-body imaging technique for PET. IEEE Trans Nucl Sci 1990;37:676–680.
Dahlbom M, Hoffman E, Hoh CK, et al.: Evaluation of a positron emission tomography (PET) scanner for whole body imaging. J Nucl Med 1992;33:1191–1199.
Gambhir S, Czernin J, Schwimmer J, et al.: A tabulated summary of the 2-[F-18]fluorodeoxyglucose (FDG) positron emission tomography (PET) literature. J Nucl Med 2001;42:15.
Karp J, Muehllehner G, Mankoff D, et al.: Continuous-slice PENN-PET: A positron tomography with volume imaging capability. J Nucl Med 1990;31:617–627.
Beyer T, Townsend DT, Brun T, et al.: A combined PET/CT scanner for clinical oncology. J Nucl Med 2000;41:1369–1379.
Patton JA, Delbeke D, Sandler MP: Image fusion using integrated dual-head coincidence camera with x-ray tube based attenuation maps. J Nucl Med 2000;41:1364–1368.
Shreve, P: Adding structure to function. J Nucl Med 2000;41:1380–1381.
Casey M, Eriksson L, Schmand M, et al.: Investigation of LSO crystals for high spatial resolution positron emission tomography. IEEE Trans Nucl Sci 1997;44:1109–1113.
Gambhir SS, Barrio JR, Phelps ME, et al.: Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci USA 1999;96:2333–2338.
Tjuvajev JG, Chen SH, Joshi A, et al.: Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer expression in vivo. Cancer Res 1999;59:5186–5193.
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Phelps, M.E. (2002). History of PET. In: Delbeke, D., Martin, W.H., Patton, J.A., Sandler, M.P. (eds) Practical FDG Imaging: A Teaching File. Springer, New York, NY. https://doi.org/10.1007/978-0-387-22453-4_1
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DOI: https://doi.org/10.1007/978-0-387-22453-4_1
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