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Polycystic Ovarian Syndrome and Gynaecological Cancer

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Book cover Diagnosis and Management of Polycystic Ovary Syndrome
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Polycystic ovarian syndrome (PCOS) is the most common female endocrine disturbance and is associated with an increased risk of gynaecological cancers. Endometrial adenocarcinoma has long been associated with PCOS particularly in premenopausal women. Breast cancer is more common in women with PCOS. The studies on epithelial ovarian cancer are conflicting but overall do not suggest a major increase in risk (Fig. 13.1).

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References

  1. Office for National Statistics. Cancer statistics – registrations, England, 2004. Series MB1 no. 35. London: Office for National Statistics, 2005.

    Google Scholar 

  2. Jackson RL, Dockerty MB. The Stein-Leventhal Syndrome: analysis of 43 cases with special reference to association with endometrial carcinoma. American Journal of Obstetrics and Gynaecology 1957;73:161–173.

    Google Scholar 

  3. Coulam CB, Annergers JF, Kranz JS. Chronic anovulation syndrome and associated neoplasia. Obstetrics and Gynecology 1983;61:403–407.

    PubMed  CAS  Google Scholar 

  4. Potischman N, Hoover RN, Brinton LA, Siiteri P. Case-control study of endogenous steroid hormones and endometrial cancer. Journal of the National Cancer Institute 1996;88:1127–1135.

    Article  PubMed  CAS  Google Scholar 

  5. Troisi R, Potischman N, Hoover RN, Siiteri P, Brinton LA. Insulin and endometrial cancer. American Journal of Epidemiology 1997;146:476–482.

    PubMed  CAS  Google Scholar 

  6. Ron E, Lunenfeld B, Menczer J, Blumstein T, Katz L. Cancer incidence in a cohort of infertile women. American Journal of Epidemiology 1987;125:780–790.

    PubMed  CAS  Google Scholar 

  7. Escobado LG, Lee NC, Peterson HB, Wingo PA. Infertility associated endometrial cancer risk may be limited to specific subgroups of infertile women. Obstetrics and Gynecology 1991; 77:124–128.

    Google Scholar 

  8. Brinton LA, Berman ML, Mortel, R, Twiggs LB, Barrett RJ. Reproductive, menstrual and medical risk factors for endometrial cancer: results from a case control study. American Journal of Obstetrics and Gynaecology 1992;167:1317–1325.

    CAS  Google Scholar 

  9. Elwood JM, Cole P Rothman KJ. Epidemiology of ovarian cancer. Journal of the National Cancer Institute 1977;59:1055–1060.

    PubMed  CAS  Google Scholar 

  10. Dahlgren E, Friberg L-G, Johansson S, Lindstrom B. Endometrial carcinoma; ovarian dysfunction – a risk factor in young women. Journal of Obstetrics, Gynecology and Reproductive Biology 1991;41: 143–150.

    Article  CAS  Google Scholar 

  11. Key TJ, Allen NE, Spencer EA, Travis RC. The effect of diet on the risk of cancer. Lancet 2002;360:861–868.

    Article  PubMed  CAS  Google Scholar 

  12. Levi F, LaVecchia C, Negri E, Franceschi S. Selected physical activities and the risk of endometrial cancer. British Journal of Cancer 1993;67:846–851.

    Article  PubMed  CAS  Google Scholar 

  13. Akhmedkhanov A, Zeleniuch-Jacquotte A, Toniolo P. Role of exogenous and endogenous hormones in endometrial cancer: review of the evidence and research perspectives. Annals of the New York Academy of Science 2001;943:296–315.

    Article  CAS  Google Scholar 

  14. Gusberg SB. Precursors of corpus carcinoma. Estrogens and adenomatous hyperplasia. American Journal of Obstetrics and Gynecology 1947;53:419–423.

    PubMed  Google Scholar 

  15. Kurman R, Kamisnski P, Norris H. The behaviour of endometrial hyperplasia, a long-term study of untreated hyperplasia in 170 patients. Cancer 1985;56:403–412.

    Article  PubMed  CAS  Google Scholar 

  16. Lindahl B, Willen R. Spontaneous endometrial endometrial hyperplasia. A prospective, 5 year follow up of 246 patients after abrasion only, including 380 patients followed up for 2 years. Anticancer research 1994;14:2141–2146.

    PubMed  CAS  Google Scholar 

  17. Wentz W. Progestin therapy in endometrial hyperplasia. Gynecologic oncology 1974;2:362–367.

    Article  PubMed  CAS  Google Scholar 

  18. Kohler M, Berchuck A, Davidoff A. Overexpression and mutation of p53 in endometrial carcinoma. Cancer Research 1992; 52:1622–1625.

    PubMed  CAS  Google Scholar 

  19. Kohler M, Nishii H, Humphrey P. Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias. American Journal of Obstetrics and Gynecology 1993; 169:690–695.

    PubMed  CAS  Google Scholar 

  20. Sasaki H, Nishii H, Takahashi H. Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma. Cancer research 1993;53:1906–1911.

    PubMed  CAS  Google Scholar 

  21. Gregory C, Wilson E, Apparao K. Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometrium. Journal of Clinical Endocrinology and Metabolism 2002;85:2960–2966.

    Article  Google Scholar 

  22. Koss L, Schreiber K, Oberlander S. Detection of endometrial carcinoma and hyperplasia in asymptomatic women. Obstetrics and Gynecology 1984;64:1–11.

    PubMed  CAS  Google Scholar 

  23. Gull B, Karlsson B, Milsom I, Granberg S. Can ultrasound replace dilation and curettage? A longitudinal evaluation of postmenopausal bleeding and transvaginal sonographic measurement of the endometrium as predictors of endometrial cancer. American Journal of Obstetrics and Gynecology 2003;188:401–408.

    Article  PubMed  CAS  Google Scholar 

  24. Langer R, Pierce J, O’Hanlan K. Transvaginal ultrasonography compared with endometrial biopsy for the detection of endometrial disease. Postmenopausal estrogen/progestin interventions trial. New England Journal of Medicine 1997;337:1792–1798.

    Article  PubMed  CAS  Google Scholar 

  25. RCOG Green Top Guideline No. 33 Long Teem consequences of polycystic ovarian syndrome. May 2003. RCOG Press.

    Google Scholar 

  26. Cheung AP. Ultrasound and menstrual history in predicting endometrial hyperplasia in polycystic ovary syndrome. Obstetrics and Gynecology 2001;98:325–331.

    Article  PubMed  CAS  Google Scholar 

  27. Balen AH. Polycystic ovary syndrome and cancer. Human Reproductive Update 2001;7:522–525.

    Article  CAS  Google Scholar 

  28. Hulka B, Chambless L, Kaufman D. Protection against endometrial carcinoma by combination-product oral contraceptives. Journal of the American Medical Association 1982;247:475–477

    Article  PubMed  CAS  Google Scholar 

  29. Vessey M, Painter R. Endometrial and ovarian cancer and oral contraceptives-findings in a large cohort study. British Journal of Cancer 1995;71:1340–1342

    Article  PubMed  CAS  Google Scholar 

  30. Rubatt JM, Slomovitz BM, Burke TW, Broaddus RR. Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia. Gynecolgical Oncology 2005;99:472–476.

    Article  Google Scholar 

  31. Fechner R, Kaufman R. Endometrial adenocarcinoma in Stein-Leventhal syndrome. Cancer 1974;34:444–452.

    Article  PubMed  CAS  Google Scholar 

  32. Farhi D, Nosanchuk J, Silverberg S. Endometrial adenocarcinoma in women under 25 years of age. Obstetrics and Gynecology 1986;68:741–745.

    PubMed  CAS  Google Scholar 

  33. Gotlieb WH, Beiner ME, Shalmon B. Outcome of fertility-sparing treatment with progestins in young patients with endometrial cancer. Obstetrics and Gynecology 2003;102:718–725.

    Article  PubMed  CAS  Google Scholar 

  34. Ota T, Yoshida M, Kimura M, Kinoshita K. Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger. International Journal of Gynecological Cancer. 2005;15:657–662.

    Article  PubMed  CAS  Google Scholar 

  35. Yamazawa K, Hirai M, Fujito A. Fertility-preserving treatment with progestin, and pathological criteria to predict responses, in young women with endometrial cancer. Human Reproduction 2007;22:1953–1958.

    Article  PubMed  CAS  Google Scholar 

  36. Walsh C, Holschneider C, Hoang Y. Coexisting ovarian malignancy in young women with endometrial cancer. Obstetrics and Gynecology 2005;106:693–699.

    Article  PubMed  Google Scholar 

  37. Hallak M, Peipert JF, Heller PB, Sedlacek T, Schauer G. Mullerian adenosarcoma of the uterus with sarcomatous overgrowth. Journal of Surgical Oncology 1992;51:68–70.

    Article  PubMed  CAS  Google Scholar 

  38. Press M, Scully R. Endometrial sarcomas complicating ovarian thecoma, polycystic ovarian disease and estrogen therapy. Gynecological Oncology 1985;21:135–154.

    Article  CAS  Google Scholar 

  39. Chumas J, Mann W, Tseng L. Malignant mixed Mullerian tumour of the endometrium in a young woman with polycystic ovaries. Cancer 1983;52:1478–1481.

    Article  PubMed  CAS  Google Scholar 

  40. Coulam C, Annegers J, Kranz J. Chronic anovulation syndrome and associated neoplasia. Obstetrics and Gynecology 1983;61:403–407.

    PubMed  CAS  Google Scholar 

  41. Gammon M, Thompson W. Polycystic ovaries and the risk of breast cancer. American Journal of Epidemiology 1991;134:818–824.

    PubMed  CAS  Google Scholar 

  42. Anderson K, Sellers T, Chen P, Rich S, Hong C, Folsom A. Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa. Cancer 1997;79:494–499.

    Article  PubMed  CAS  Google Scholar 

  43. Pierpoint T, McKeigue P, Isaacs A. Mortality of women with polycystic ovarian syndrome at long term follow up. Journal of Clinical Epidemiology 1998;51:581–586.

    Article  PubMed  CAS  Google Scholar 

  44. Quinn M, Babb P, Brock A. Cancer trends in England and Wales 1950 to 1999. Studies on medical and population subjects no. 66, 2001, Her Majesty’s Stationery Office, London.

    Google Scholar 

  45. Fathalla M. Incessant ovulation- a factor in ovarian neoplasia? Lancet 1971; 11:163.

    Article  Google Scholar 

  46. McGowan L, Parent L, Lednar W. The woman at risk for developing ovarian cancer. Gynecological Oncology 1979;7:325–344.

    Article  CAS  Google Scholar 

  47. Whittemore A, Harris R, Itnyre J. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies II. Invasive epithelial cancers in white women. Collaborative ovarian cancer group. American Journal of Epidemiology 1992;136:1212–1220.

    PubMed  CAS  Google Scholar 

  48. Rossing M, Daling J, Weiss N. Ovarian tumours in a cohort of infertile women. New England Journal of Medicine 1994;331:771–776.

    Article  PubMed  CAS  Google Scholar 

  49. Schildkraut J, Schwingl P, Bastos E, Evanoff A, Hughes C. Epithelial ovarian cancer risk among women with polycystic ovarian syndrome. Obstetrics and Gynecology 1996;88:554–559.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Alexandra Lawrence .

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Lawrence, A., Mason, W.P. (2009). Polycystic Ovarian Syndrome and Gynaecological Cancer. In: Farid, N.R., Diamanti-Kandarakis, E. (eds) Diagnosis and Management of Polycystic Ovary Syndrome. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09718-3_13

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  • DOI: https://doi.org/10.1007/978-0-387-09718-3_13

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