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Patient-Specific Modeling and Simulation of Deep Brain Stimulation

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Patient-Specific Modeling in Tomorrow's Medicine

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 09))

Abstract

Deep brain stimulation (DBS) is widely used for reduction of symptoms caused by movement disorders. In this chapter a patient-specific finite element method for modeling and simulation of DBS electric parameters is presented. The individual’s stereotactic preoperative MR-batch of images is used as input to the model in order to classify tissue type and allot electrical conductivity for cerebrospinal fluid, blood and grey as well as white matter. With patient-specific positioning of the DBS electrodes the method allows for investigation of the relative electric field changes in relation to anatomy and DBS-settings. Examples of visualization of the patient-specific electric entities together with the surrounding anatomy are given. The use of the method is exemplified on patients with Parkinson’s disease. Future applications including multiphysics simulations and applicability for new DBS targets and symptoms are discussed.

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Acknowledgements

The authors would like to thank the clinical collegues at the Unit of Functional Neurosurgery, London University Collegue and at the Division of Neurology and Neurosurgery at Linköping University Hospital for very valuable input and discussions during the development of the software. The work was financially supported as a group grant (311-2006-7661) by the Swedish Foundation for Strategic Research (SSF), the Swedish Research Council (VR) and the Swedish Governmental Agency for Innovation Systems (VINNOVA).

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Authors and Affiliations

  1. Department of Biomedical Engineering, Linköping University, Linköping, Sweden

    Karin Wårdell, Elin Diczfalusy & Mattias Åström

Authors
  1. Karin Wårdell
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  2. Elin Diczfalusy
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  3. Mattias Åström
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Corresponding author

Correspondence to Karin Wårdell .

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Editors and Affiliations

  1. Fac. Engineering, Dept. Biomedical Engineering, Tel Aviv University, Ramat Aviv, 69978, Israel

    Amit Gefen

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Wårdell, K., Diczfalusy, E., Åström, M. (2011). Patient-Specific Modeling and Simulation of Deep Brain Stimulation. In: Gefen, A. (eds) Patient-Specific Modeling in Tomorrow's Medicine. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 09. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2011_104

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  • DOI: https://doi.org/10.1007/8415_2011_104

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-24617-3

  • Online ISBN: 978-3-642-24618-0

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