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DNAJA3, a Co-chaperone in Development and Tumorigenesis

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Heat Shock Proteins in Inflammatory Diseases

Part of the book series: Heat Shock Proteins ((HESP,volume 22))

Abstract

Introduction: DNAJA3, also known as Tid1 (Tumorous imaginal disc 1), is a mammalian mitochondrial DNAJ/HSP40 co-chaperone protein. DNAJA3 is predominantly localized in mitochondrial matrix which enables them to interact with mitochondrial HSP70 or other client proteins. This chapter summarizes the physiological and biochemical functions of DNAJA3 in tumorigenesis, development and mitochondrial homeostasis, and its underlying molecular mechanisms.

Methods: All literatures were systematically searched through EndNote and web search engines. The reported discoveries and our findings were specifically categorized into multiple roles of DNAJA3.

Results: DNAJA3 has been identified as tumor suppressor. Overexpression of DNAJA3 not only inhibits cancer cells proliferation but also induces cells death. In opposite, downregulation of DNAJA3 enhances malignant properties such as cell migration and invasion in vitro, and tumor growth in vivo. Acting as a tumor suppressor, DNAJA3 can interfere with the matrix metalloproteinase to repress the cancer metastasis. Additionally, DNAJA3 is involved in early embryogenesis, thymocyte development, muscular development and mitochondrial biogenesis in normal physiological condition. Mechanistically, DNAJA3 interacts with DNAK/HSP70 to prevent aggregation of mitochondrial complex I and to contribute mtDNA maintenance.

Conclusions: Most of DNAJA3 client proteins are related to cancer. Therefore, it is of the importance of DNAJA3 to orchestrate its function in tumorigenesis. DNAJA3 also important in development and mitochondrial homeostasis.

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Abbreviations

APC:

Adenomatous polyposis coli

CRC:

Colorectal cancer

Cyt:

Cytoplasmic

DCM:

Dilated cardiomyopathy

EBV:

Epstein-Barr virus

EGFR:

Epidermal growth factor receptor

EOPD:

Early onset Parkinson’s

ER:

Endoplasmic reticulum

HBV:

Hepatitis B virus

HCC:

Hepatocellular carcinoma

hERG:

Human ether-a-go-go-related gene

HGF:

Hepatocyte growth factor

HNSCC:

Head and neck squamous cell carcinoma

HSP:

Heat shock protein

HSV:

Herpes simplex virus type 1

HTLV-1:

Human T cell leukemia virus type 1

MEF:

Mouse embryonic fibroblast

Mem:

Membrane

MetR:

c-Met receptor tyrosine kinase

Mito:

Mitochondria

NSCLC:

Non-small cell lung carcinoma

Opa1:

Optic atrophy 1

RCC-CICs:

Renal cell carcinoma cancer- initiating cells

Tid1:

Tumorous imaginal disc 1

TNFα:

Tumor necrosis factor-alpha

VHL:

Von Hippel-Lindau protein

YY1:

Yin Yang 1

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Acknowledgements

This study was supported by grants from National Yang-Ming University (108CRC-T402) and the Ministry of Science and Technology, Taiwan (MOST 107-2314-B-010-024-MY3).

Disclosure of Interests

All authors declare they have no conflict of interest.

Ethical Approval for Studies Involving Humans

This article does not contain any studies with human participants performed by any of the authors.

Ethical Approval for Studies Involving Animals

This article does not contain any studies with animals performed by any of the authors.

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Authors and Affiliations

  1. Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan

    Wan-Huai Teo & Jeng-Fan Lo

  2. Department & Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan

    Yu-Ning Fann & Jeng-Fan Lo

  3. Cancer Progression Research Center, National Yang-Ming University, Taipei, Taiwan

    Jeng-Fan Lo

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  1. Wan-Huai Teo
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Correspondence to Jeng-Fan Lo .

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Editors and Affiliations

  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Punit Kaur

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Teo, WH., Fann, YN., Lo, JF. (2020). DNAJA3, a Co-chaperone in Development and Tumorigenesis. In: Asea, A.A.A., Kaur, P. (eds) Heat Shock Proteins in Inflammatory Diseases. Heat Shock Proteins, vol 22. Springer, Cham. https://doi.org/10.1007/7515_2020_33

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